| Both mir-615-3p and HOXC5 are activated upon differentiation, which constitute a feed-forward loop that coordinates transcriptional and post-transcriptional repression of hTERT during cellular differentiation. Deregulation of HOXC5 and mir-615-3p expression may contribute to the activation of hTERT in human cancers. | HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis.
Yan T, Ooi WF, Qamra A, Cheung A, Ma D, Sundaram GM, Xu C, Xing M, Poon L, Wang J, Loh YP, Ho JHJ, Ng JJQ, Ramlee MK, Aswad L, Rozen SG, Ghosh S, Bard FA, Sampath P, Tergaonkar V, Davies JOJ, Hughes JR, Goh E, Bi X, Fullwood MJ, Tan P, Li S., Free PMC Article | 12/22/2018 |
| The A17860G located in 3'flanking sequence of HOXC5 gene is associated with simple congenital heart disease; the haplotype of 3 SNPs may be linked with the susceptible gene of simple CHD. | Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease.
Gong LG, Qiu GR, Jiang H, Xu XY, Zhu HY, Sun KL, Gong LG, Qiu GR, Jiang H, Xu XY, Zhu HY, Sun KL. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease.
Gong LG, Qiu GR, Jiang H, Xu XY, Zhu HY, Sun KL, Gong LG, Qiu GR, Jiang H, Xu XY, Zhu HY, Sun KL. | 03/13/2008 |