| Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci. | Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.
Zhang Q, Chen X, Li S, Yao T, Wu J. | 08/21/2021 |
| GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task. | GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task.
Bauer LO, Covault JM., Free PMC Article | 02/2/2021 |
| Transcriptional activation of GRM8 lung squamous cell carcinoma tumor cells induced cell proliferation by inhibiting cAMP pathway and activating MAPK pathway. | Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer.
Zhang P, Kang B, Xie G, Li S, Gu Y, Shen Y, Zhao X, Ma Y, Li F, Si J, Wang J, Chen J, Yang H, Xu X, Yang Y. | 11/9/2019 |
| rs712723 in GRM8 was selected for genotyping. The allele C and genotype CC (allele C: OR 1.48, 95% CI 1.13-1.94; genotype CC: OR 1.71, 95% CI 1.09-2.68) of rs712723 polymorphism was found to have a significant association with risk of schizophrenia while allele T (P = 0.003) and genotype TT (P = 0.028) frequencies were found lower in control patients. | TCF4 and GRM8 gene polymorphisms and risk of schizophrenia in an Iranian population: a case-control study.
Tavakkoly-Bazzaz J, Azarnezhad A, Mousavi N, Salehipour P, Shahsavand Ananloo E, Alizadeh F. | 04/27/2019 |
| This study showed that GRM8 was nominally associated (p < 0.05) with both delta measures (energy and intertrial phase coherence). | What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude?
Malone SM, McGue M, Iacono WG., Free PMC Article | 08/26/2017 |
| Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population | Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population.
Li W, Ju K, Li Z, He K, Chen J, Wang Q, Yang B, An L, Feng G, Sun W, Zhou J, Zhang S, Song P, Khan RAW, Ji W, Shi Y. | 10/29/2016 |
| These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence. | Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults.
Long EC, Aliev F, Wang JC, Edenberg HJ, Nurnberger J Jr, Hesselbrock V, Porjesz B, Dick DM., Free PMC Article | 04/23/2016 |
| Genome wide association study and meta-analysis results detected rs6951643, a GRM8 genetic variant as suggestive marker for sporadic Creutzfeldt-Jakob disease risk mapping outside the PRNP region. | A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk.
Sanchez-Juan P, Bishop MT, Kovacs GG, Calero M, Aulchenko YS, Ladogana A, Boyd A, Lewis V, Ponto C, Calero O, Poleggi A, Carracedo Á, van der Lee SJ, Ströbel T, Rivadeneira F, Hofman A, Haïk S, Combarros O, Berciano J, Uitterlinden AG, Collins SJ, Budka H, Brandel JP, Laplanche JL, Pocchiari M, Zerr I, Knight RS, Will RG, van Duijn CM., Free PMC Article | 01/16/2016 |
| propose three potential human candidate genes for voluntary physical exercise levels (MC3R, CYP24A1, and GRM8). | A candidate syntenic genetic locus is associated with voluntary exercise levels in mice and humans.
Kostrzewa E, Brandys MK, van Lith HA, Kas MJ. | 08/15/2015 |
| The GRM8 gene might play an important role in the pathogenesis of schizophrenia. | Association analysis of the GRM8 gene with schizophrenia in the Uygur Chinese population.
Zhang L, Zhong X, An Z, Han S, Luo X, Shi Y, Yi Q. | 05/30/2015 |
| Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain | Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain.
Yanagawa M, Yamashita T, Shichida Y., Free PMC Article | 06/1/2013 |
| Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1, PTPRD, GRM8, CMIP. | Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways.
Girotto G, Pirastu N, Sorice R, Biino G, Campbell H, d'Adamo AP, Hastie ND, Nutile T, Polasek O, Portas L, Rudan I, Ulivi S, Zemunik T, Wright AF, Ciullo M, Hayward C, Pirastu M, Gasparini P. | 10/1/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Response to methadone maintenance treatment is associated with the MYOCD and GRM6 genes.
Fonseca F, Gratacòs M, Escaramís G, De Cid R, Martín-Santos R, Fernández-Espejo E, Estivill X, Torrens M. | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Association of suingle nucleotide polymorphisms in GRM8 with theta power of event-related oscillations and alcohol dependence are reported. | Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.
Chen AC, Tang Y, Rangaswamy M, Wang JC, Almasy L, Foroud T, Edenberg HJ, Hesselbrock V, Nurnberger J Jr, Kuperman S, O'Connor SJ, Schuckit MA, Bauer LO, Tischfield J, Rice JP, Bierut L, Goate A, Porjesz B, Chen AC, Tang Y, Rangaswamy M, Wang JC, Almasy L, Foroud T, Edenberg HJ, Hesselbrock V, Nurnberger J Jr, Kuperman S, O'Connor SJ, Schuckit MA, Bauer LO, Tischfield J, Rice JP, Bierut L, Goate A, Porjesz B., Free PMC Articles: PMC2660384, PMC2660384 | 01/21/2010 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB., Free PMC Article | 02/11/2009 |
| GRM8 genes are likely involved in the pathogenesis of autistic disorder. | The association analysis of RELN and GRM8 genes with autistic spectrum disorder in Chinese Han population.
Li H, Li Y, Shao J, Li R, Qin Y, Xie C, Zhao Z, Li H, Li Y, Shao J, Li R, Qin Y, Xie C, Zhao Z. | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesHuman variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL. Genome-wide association study of smoking initiation and current smoking.
Vink JM, Smit AB, de Geus EJ, Sullivan P, Willemsen G, Hottenga JJ, Smit JH, Hoogendijk WJ, Zitman FG, Peltonen L, Kaprio J, Pedersen NL, Magnusson PK, Spector TD, Kyvik KO, Morley KI, Heath AC, Martin NG, Westendorp RG, Slagboom PE, Tiemeier H, Hofman A, Uitterlinden AG, Aulchenko YS, Amin N, van Duijn C, Penninx BW, Boomsma DI. Systematic association mapping identifies NELL1 as a novel IBD disease gene.
Franke A, Hampe J, Rosenstiel P, Becker C, Wagner F, Häsler R, Little RD, Huse K, Ruether A, Balschun T, Wittig M, Elsharawy A, Mayr G, Albrecht M, Prescott NJ, Onnie CM, Fournier H, Keith T, Radelof U, Platzer M, Mathew CG, Stoll M, Krawczak M, Nürnberg P, Schreiber S. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (9) articlesComprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.
Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X. A common variant in DRD3 receptor is associated with autism spectrum disorder.
de Krom M, Staal WG, Ophoff RA, Hendriks J, Buitelaar J, Franke B, de Jonge MV, Bolton P, Collier D, Curran S, van Engeland H, van Ree JM. Gene variants associated with ischemic stroke: the cardiovascular health study.
Luke MM, O'Meara ES, Rowland CM, Shiffman D, Bare LA, Arellano AR, Longstreth WT Jr, Lumley T, Rice K, Tracy RP, Devlin JJ, Psaty BM. Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.
Chen AC, Tang Y, Rangaswamy M, Wang JC, Almasy L, Foroud T, Edenberg HJ, Hesselbrock V, Nurnberger J Jr, Kuperman S, O'Connor SJ, Schuckit MA, Bauer LO, Tischfield J, Rice JP, Bierut L, Goate A, Porjesz B, Chen AC, Tang Y, Rangaswamy M, Wang JC, Almasy L, Foroud T, Edenberg HJ, Hesselbrock V, Nurnberger J Jr, Kuperman S, O'Connor SJ, Schuckit MA, Bauer LO, Tischfield J, Rice JP, Bierut L, Goate A, Porjesz B. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction.
Nielsen DA, Ji F, Yuferov V, Ho A, Chen A, Levran O, Ott J, Kreek MJ. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.
Shiffman D, O'Meara ES, Bare LA, Rowland CM, Louie JZ, Arellano AR, Lumley T, Rice K, Iakoubova O, Luke MM, Young BA, Malloy MJ, Kane JP, Ellis SG, Tracy RP, Devlin JJ, Psaty BM. The association analysis of RELN and GRM8 genes with autistic spectrum disorder in Chinese Han population.
Li H, Li Y, Shao J, Li R, Qin Y, Xie C, Zhao Z, Li H, Li Y, Shao J, Li R, Qin Y, Xie C, Zhao Z. Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia.
Takaki H, Kikuta R, Shibata H, Ninomiya H, Tashiro N, Fukumaki Y. No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals.
Preuss UW, Koller G, Bahlmann M, Zill P, Soyka M, Bondy B. | 03/13/2008 |
| Polymorphism not associated with panic disorder. | Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder.
Kobayashi Y, Akiyoshi J, Kanehisa M, Ichioka S, Tanaka Y, Tsuru J, Hanada H, Kodama K, Isogawa K, Tsutsumi T. | 01/21/2010 |
| Pias1 binds to and sumoylates metabotropic glutamate receptor 8 | Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.
Tang Z, El Far O, Betz H, Scheschonka A. | 01/21/2010 |