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    Il27 interleukin 27 [ Mus musculus (house mouse) ]

    Gene ID: 246779, updated on 24-Jun-2016

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    IL-27 induces the endothelial differentiation in cardiac resident stem cells through STAT3/Pim-1 signaling pathway.

    Interleukin-27 induces the endothelial differentiation in Sca-1+ cardiac resident stem cells.
    Tanaka T, Obana M, Mohri T, Ebara M, Otani Y, Maeda M, Fujio Y.

    demonstrate that suppression mediated by interferon and IL-27 is a negative feedback mechanism for group 2 innate lymphoid cells function in vivo

    Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses.
    Moro K, Kabata H, Tanabe M, Koga S, Takeno N, Mochizuki M, Fukunaga K, Asano K, Betsuyaku T, Koyasu S.

    Natural killer cells-dendritic cells interaction elicits a positive feedback loop for IFN-gamma and IL-27 production.

    NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis.
    Chong WP, van Panhuys N, Chen J, Silver PB, Jittayasothorn Y, Mattapallil MJ, Germain RN, Caspi RR., Free PMC Article

    demonstrate the essential role of IL-27 signaling in regulating immune responses to extracellular protozoan infections

    IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ.
    Liu G, Xu J, Wu H, Sun D, Zhang X, Zhu X, Magez S, Shi M., Free PMC Article

    IL-27 regulates enhanced susceptibility to S. aureus pneumonia following influenza infection, potentially through the induction of IL-10 and suppression of IL-17.

    The role of IL-27 in susceptibility to post-influenza Staphylococcus aureus pneumonia.
    Robinson KM, Lee B, Scheller EV, Mandalapu S, Enelow RI, Kolls JK, Alcorn JF., Free PMC Article

    These data identify an IL-27/NFIL3 signalling axis as a key regulator of effector T-cell responses via induction of Tim-3, IL-10 and T-cell dysfunction.

    An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.
    Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK., Free PMC Article

    Importance of IL-27 for the physiological control of immunopathology and the potential value of well-timed IL-27 application to treat life-threatening inflammation during lung infection.

    Timed action of IL-27 protects from immunopathology while preserving defense in influenza.
    Liu FD, Kenngott EE, Schröter MF, Kühl A, Jennrich S, Watzlawick R, Hoffmann U, Wolff T, Norley S, Scheffold A, Stumhofer JS, Saris CJ, Schwab JM, Hunter CA, Debes GF, Hamann A., Free PMC Article

    Most innate immune receptor agonist-based vaccine adjuvants need IL-27 for CD4 and CD8 responses. IL-27 dependency is T-cell-intrinsic, requiring T-cell expression of IL-27Ralpha. It is critical high-affinity T-cell response to subunit immunization.

    IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization.
    Pennock ND, Gapin L, Kedl RM., Free PMC Article

    Our study has identified a novel proinflammatory role for IL-27 in vivo that promotes Th17 differentiation by inducing Th17-supporting cytokines in APCs.

    IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice.
    Visperas A, Do JS, Bulek K, Li X, Min B., Free PMC Article

    IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses.

    IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses.
    Chong WP, Horai R, Mattapallil MJ, Silver PB, Chen J, Zhou R, Sergeev Y, Villasmil R, Chan CC, Caspi RR., Free PMC Article

    Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-gamma for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages.

    Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages.
    McNab FW, Ewbank J, Howes A, Moreira-Teixeira L, Martirosyan A, Ghilardi N, Saraiva M, O'Garra A., Free PMC Article

    IL-27/WSX-1 regulated PGE2 secretion via STAT1-COX-2 pathway in macrophages and affected helper T cell response in a PGE2-mediated fashion.

    IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages.
    Sato Y, Hara H, Okuno T, Ozaki N, Suzuki S, Yokomizo T, Kaisho T, Yoshida H.

    In conclusion, it is suggested that IL-27 may possibly act as an anti-inflammatory cytokine during malaria.

    Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice.
    Fazalul Rahiman SS, Basir R, Talib H, Tie TH, Chuah YK, Jabbarzare M, Chong WC, Mohd Yusoff MA, Nordin N, Yam MF, Abdullah WO, Abdul Majid R.

    IL-27 plays a critical role in the parent-to-F1 model of acute graft versus host disease and that blocking IL-27 could have therapeutic relevance

    IL-27p28 is essential for parent-to-F1 acute graft-versus-host disease.
    Marillier RG, Uyttenhove C, Goriely S, Marbaix E, Van Snick J.

    this report identifies Tyk2 as a prerequisite factor in the molecular networks that are involved in generation of IL-27.

    Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.
    Bosmann M, Strobl B, Kichler N, Rigler D, Grailer JJ, Pache F, Murray PJ, Müller M, Ward PA., Free PMC Article

    these data demonstrate that in contrast to viral infections at other sites, IL-27 does not play a proinflammatory role during JHMV-induced encephalomyelitis.

    IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination.
    de Aquino MT, Kapil P, Hinton DR, Phares TW, Puntambekar SS, Savarin C, Bergmann CC, Stohlman SA., Free PMC Article

    Data indicate that while diminishing IL-12 and IL-23 secretion, sphingosine-1-phosphate (S1P) enhanced IL-27 production in dendritic cells (DCs).

    Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells.
    Schaper K, Kietzmann M, Bäumer W.

    IL-27 production by CD11c(+) cells was inhibited.

    Oral Escherichia coli colonization factor antigen I fimbriae ameliorate arthritis via IL-35, not IL-27.
    Kochetkova I, Thornburg T, Callis G, Holderness K, Maddaloni M, Pascual DW., Free PMC Article

    the findings from the past decade identify IL-27 as a critical immunoregulatory cytokine, especially for T cells, whereas some controversy is fueled by results challenging the view of IL-27 as a classical silencer of inflammation.

    Modulation of inflammation by interleukin-27.
    Bosmann M, Ward PA., Free PMC Article

    IL-27 suppresses the production of IFN-gamma by CD4+ T cells during blood stage malaria infection by preventing the development of terminally differentiated Th1 cells specifically by restricting IL-12 signals.

    IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.
    Villegas-Mendez A, de Souza JB, Lavelle SW, Gwyer Findlay E, Shaw TN, van Rooijen N, Saris CJ, Hunter CA, Riley EM, Couper KN., Free PMC Article

    IL-27 promotes protective immune responses against endogenous tumors, which is critical as the basis for future development of an IL-27 based therapeutic agent.

    Interleukin-27 signaling promotes immunity against endogenously arising murine tumors.
    Natividad KD, Junankar SR, Mohd Redzwan N, Nair R, Wirasinha RC, King C, Brink R, Swarbrick A, Batten M., Free PMC Article

    Findings define a novel inhibitory role for IL-27 in atherosclerosis that regulates macrophage activation in mice.

    Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice.
    Hirase T, Hara H, Miyazaki Y, Ide N, Nishimoto-Hazuku A, Fujimoto H, Saris CJ, Yoshida H, Node K.

    Dendritic cell (DC)-derived IL-27 is required for shaping tumor microenvironment in natural killer (NK) and NKT cell-dependent antitumor immunity.

    Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation of NK and NKT cells.
    Wei J, Xia S, Sun H, Zhang S, Wang J, Zhao H, Wu X, Chen X, Hao J, Zhou X, Zhu Z, Gao X, Gao JX, Wang P, Wu Z, Zhao L, Yin Z.

    Report elevated Il27 expression by neonatal macrophages resulting in immunosuppression.

    Neonatal macrophages express elevated levels of interleukin-27 that oppose immune responses.
    Kraft JD, Horzempa J, Davis C, Jung JY, Peña MM, Robinson CM., Free PMC Article

    IL-27 exerts a pro-inflammatory role by enhancing NO production in peritoneal macrophages stimulated with LPS through activation of STAT1, NF-kappaB and MAPKs.

    IL-27 promotes nitric oxide production induced by LPS through STAT1, NF-κB and MAPKs.
    Shimizu M, Ogura K, Mizoguchi I, Chiba Y, Higuchi K, Ohtsuka H, Mizuguchi J, Yoshimoto T.

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