| Overexpression of MiR-29b-3p Inhibits Atrial Remodeling in Rats by Targeting PDGF-B Signaling Pathway. | Overexpression of MiR-29b-3p Inhibits Atrial Remodeling in Rats by Targeting PDGF-B Signaling Pathway.
Lv X, Lu P, Hu Y, Xu T., Free PMC Article | 09/11/2021 |
| Tensile force-induced PDGF-BB/PDGFRbeta signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement. | Tensile force-induced PDGF-BB/PDGFRβ signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement.
Jin Y, Ding L, Ding Z, Fu Y, Song Y, Jing Y, Li Q, Zhang J, Ni Y, Hu Q., Free PMC Article | 02/2/2021 |
| In cultured rat aortic SMCs, PDGF stimulation rapidly promoted ATP7A association with IQGAP1 and Rac1 and their translocation to the lipid rafts and leading edge. Cotransfection assay revealed that ATP7A directly bound to NH2-terminal domain of IQGAP1 | Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding scaffolding protein: role in PDGF-induced VSMC migration and vascular remodeling.
Ashino T, Kohno T, Sudhahar V, Ash D, Ushio-Fukai M, Fukai T., Free PMC Article | 07/13/2019 |
| Csis inhibited the H2O2induced apoptosis of Buffalo rat liver cells in vitro, and alleviated liver injury, improved liver function, and decreased mortality rates in rat models of fulminant hepatic failure. | Overexpression of C‑sis inhibits H2O2‑induced Buffalo rat liver cell apoptosis in vitro and alleviates liver injury in a rat model of fulminant hepatic failure.
Ding H, Wen Z., Free PMC Article | 10/20/2018 |
| BM-EPCs along with SP promote the pericyte-like coverage of BM-MSCs on endothelial tubules possibly through the induction of PDGF-BB. | Endothelial precursor cells stimulate pericyte-like coverage of bone marrow-derived mesenchymal stem cells through platelet-derived growth factor-BB induction, which is enhanced by substance P.
Zhang M, Ahn W, Kim S, Hong HS, Quan C, Son Y., Free PMC Article | 07/14/2018 |
| Warburg effect plays a critical role in PDGF-induced pulmonary arterial smooth muscle cells proliferation and is mediated by activation of the PI3K signaling pathway and HIF-1alpha. | PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway.
Xiao Y, Peng H, Hong C, Chen Z, Deng X, Wang A, Yang F, Yang L, Chen C, Qin X. | 10/28/2017 |
| These effects of digoxin were shown to be mediated, at least in part, through an increase in ILK/Akt signaling and a decrease in GSK-3beta signaling in PDGFBB-stimulated VSMCs | Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury.
Yan G, Wang Q, Hu S, Wang D, Qiao Y, Ma G, Tang C, Gu Y., Free PMC Article | 06/28/2016 |
| Combined inhibition of PGDF and VEGF with sunitinib prevents chronic rejection changes in experimental kidney transplantation. | Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in Experimental Kidney Transplantation Model.
Rintala JM, Savikko J, Palin N, Rintala SE, Koskinen PK, von Willebrand E. | 04/23/2016 |
| Endogenous PDGF-BB exerts a crucial protective effect to cultured cardiomyocytes exposed to hypoxia. | Role of endogenous PDGF-BB in cultured cardiomyocytes exposed to hypoxia.
Rong R, Wang YC, Hu LQ, He QQ, Zhou XF, Wang TH, Bu PL. | 01/16/2016 |
| expression altered in experimental Necrotizing enterocolitis | Alterations in platelet-derived growth factor expression in the pathophysiology of necrotizing enterocolitis.
Shepherd JA, Stamper E, Matheson PJ, Galganski L, Garrison RN, Madden K, Downard CD. | 12/5/2015 |
| these data underpin the role of GSK-3beta/beta-catenin as a novel target that regulates neuronal progenitor cells proliferation mediated by PDGF-BB | Platelet-derived growth factor-BB restores HIV Tat -mediated impairment of neurogenesis: role of GSK-3β/β-catenin.
Chao J, Yang L, Yao H, Buch S., Free PMC Article | 11/29/2014 |
| the TRPC6 activation mainly occurs at lipid rafts, which is regulated by the mechanical cues of surrounding materials. | The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation.
Lei L, Lu S, Wang Y, Kim T, Mehta D, Wang Y., Free PMC Article | 09/27/2014 |
| Data suggest that imatinib could attenuate myocardial remodeling and improve left ventricular dysfunction in hypertension by affecting platelet-derived growth factor and transforming growth factor-beta1 pathway without the blood pressure-lowering effect. | Imatinib mesylate attenuates myocardial remodeling through inhibition of platelet-derived growth factor and transforming growth factor activation in a rat model of hypertension.
Jang SW, Ihm SH, Choo EH, Kim OR, Chang K, Park CS, Kim HY, Seung KB. | 07/26/2014 |
| Our findings demonstrate, for the first time, that Shh is involved in PDGF-BB-induced smooth muscle cell migration and recruitment of mural cells into neovessels | Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation.
Yao Q, Renault MA, Chapouly C, Vandierdonck S, Belloc I, Jaspard-Vinassa B, Daniel-Lamazière JM, Laffargue M, Merched A, Desgranges C, Gadeau AP. | 06/7/2014 |
| The data demonstrated that the neutralization of VCAM-1 inhibited the migration of BM-MSCs induced by PDGFBB | Platelet-derived growth factor BB mediates the glioma-induced migration of bone marrow-derived mesenchymal stem cells by promoting the expression of vascular cell adhesion molecule-1 through the PI3K, P38 MAPK and NF-κB pathways.
Hu Y, Cheng P, Ma JC, Xue YX, Liu YH. | 05/17/2014 |
| PDGF-BB and basic fibroblast growth factors(bFGF) are capable of moderately stimulating Schwann cell growth: every group reaches the peak in the growth curve at 3 weeks. | Platelet-derived growth factors-BB and fibroblast growth factors-base induced proliferation of Schwann cells in a 3D environment.
Jiang H, Qu W, Li Y, Zhong W, Zhang W. | 10/19/2013 |
| these in vitro and in vivo data identify snail as a critical mediator for rBMMSC invasion induced by PDGF-BB. | Snail mediates PDGF-BB-induced invasion of rat bone marrow mesenchymal stem cells in 3D collagen and chick chorioallantoic membrane.
Lu C, Sun X, Sun L, Sun J, Lu Y, Yu X, Zhou L, Gao X. | 09/7/2013 |
| PDGF-BB induces activation of AMPK in VSMCs, and subsequently regulates the migration via both the p44/p42 MAP kinase pathway and the PI3-kinase/Akt pathway. | Adenosine monophosphate-activated protein kinase regulates platelet-derived growth factor-BB-induced vascular smooth muscle cell migration.
Iida M, Tanabe K, Matsushima-Nishiwaki R, Kozawa O, Iida H. | 04/20/2013 |
| a redox-mediated activation of PKA by PDGF-BB thus highlighting a physiological role of ROS as regulator of PKA activity in rat mesangial cells. | Platelet-derived growth factor triggers PKA-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells.
Eisel F, Boosen M, Beck M, Heide H, Wittig I, Beck KF, Pfeilschifter J. | 03/2/2013 |
| CBP may be one of the main interaction targets for Egr-1, transient activation of Egr-1 and recruitment of CBP are required for thrombin-induced PDGF-B production in endothelial cells. | Transcriptional regulation of platelet-derived growth factor-B chain by thrombin in endothelial cells: involvement of Egr-1 and CREB-binding protein.
Chen J, Xu L, Chen S, Yang J, Jiang H. | 10/13/2012 |
| Angiotensin-(1-7) treatment altered the expression of PDGF and TGF-beta1 in the kidney of diabetic rats. | [The effect of angiotensin-(1-7) on the mRNA expression of PDGF and TGF-beta1 in the kidney of diabetic rats].
Chen SP, Zheng JC, Ni LS, Chen GR, Zhou L. | 10/6/2012 |
| Chrysin can regulate intracellular PTP activity during PDGF signaling, inhibit PDGF-induced VSMC proliferation and chemotaxis, and reduce arterial intima hyperplasia in vivo. | Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs.
Lo HM, Wu MW, Pan SL, Peng CY, Wu PH, Wu WB. | 09/29/2012 |
| Down-regulation of the inflammatory factors MCP-1 and PDGF-BB may be the important molecular mechanism of jiawei huzhang san decoction acting on experimental autoimmune prostatitis. | [Effects of jiawei huzhang san decoction on the expressions of inflammatory factors MCP-1 and PDGF-BB in rat models of experimental autoimmune prostatitis].
Zhou Q, Tian XF, Gong XY, Feng YL, Hu H. | 11/19/2011 |
| Suggest the possible involvement of Hif-1alpha/PDGF-BB pathway in the development of HIV-1 associated pulmonary arterial hypertension. | Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling.
Mermis J, Gu H, Xue B, Li F, Tawfik O, Buch S, Bartolome S, O'Brien-Ladner A, Dhillon NK., Free PMC Article | 11/19/2011 |
| Ischemic preconditioning promoted the formation of mature new arteries, which may be modulated by upregulating VEGF, PDGF-B, and ADAMTS-1 expressions. | [Effect of ischemia preconditioning on pro- and anti- angiogenic molecule expression and functional arteries formation].
WANG Y, HUANG CX, CHENG JS, WANG H, WU WJ, LIAO WQ, WEN JY, KE YN, ZHENG JG. | 10/22/2011 |