| Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas. | Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas.
Zeng S, Wang Y, Ai L, Huang L, Liu Z, He C, Bai Q, Li Y. | 02/12/2024 |
| TRIB3-Regulated Akt Signal Pathway Affects Trophoblast Invasion in the Development of Preeclampsia. | TRIB3-Regulated Akt Signal Pathway Affects Trophoblast Invasion in the Development of Preeclampsia.
Sui X, Zhang L, Zhang XF, Zhang Y. | 08/28/2023 |
| TRB3 mediates vascular remodeling by activating the MAPK signaling pathway in hypoxic pulmonary hypertension. | TRB3 mediates vascular remodeling by activating the MAPK signaling pathway in hypoxic pulmonary hypertension.
Cao X, Fang X, Guo M, Li X, He Y, Xie M, Xu Y, Liu X., Free PMC Article | 03/19/2022 |
| TRB3 participated in the global cerebral ischemia and reperfusion injury-induced neuronal apoptosis | Downregulation of TRB3 protects neurons against apoptosis induced by global cerebral ischemia and reperfusion injury in rats.
Wei K, Wan L, Liu J, Zhang B, Li X, Zhang Y, Zhang C, Yao W. | 06/9/2018 |
| Silencing of TRB3 has a significant ameliorative effect on diabetic nephropathy in rats. | Silencing of TRB3 Ameliorates Diabetic Tubule Interstitial Nephropathy via PI3K/AKT Signaling in Rats.
Ma Y, Chen F, Yang S, Duan Y, Sun Z, Shi J., Free PMC Article | 03/24/2018 |
| data suggest that TRB3 mediates AGE-induced oxidative injury in beta-cells through the PKCbeta2 pathway. | TRB3 mediates advanced glycation end product-induced apoptosis of pancreatic β-cells through the protein kinase C β pathway.
Wang M, Zhang W, Xu S, Peng L, Wang Z, Liu H, Fang Q, Deng T, Men X, Lou J., Free PMC Article | 03/17/2018 |
| The TRB3 silencing alleviated adipocytes insulin resistance. With TRB3 gene silencing, protein levels of IRS-1, GLUT4 and p-AMPK were significantly increased in adipocytes. TRB3 gene silencing decreased blood glucose, ameliorated insulin sensitivity and adipose tissue remodeling in diabetic rats. TRB3 silencing decreased triglyceride, increased glycogen simultaneously in diabetic epididymal and brown adipose tissues (BAT) | TRB3 gene silencing activates AMPK in adipose tissue with beneficial metabolic effects in obese and diabetic rats.
Sun X, Song M, Wang H, Zhou H, Wang F, Li Y, Zhang Y, Zhang W, Zhong M, Ti Y. | 09/23/2017 |
| Trib3 may be associated with the pathogenic mechanism of demyelination in dmy rats. | Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats.
Shimotsuma Y, Tanaka M, Izawa T, Yamate J, Kuwamura M., Free PMC Article | 07/8/2017 |
| results suggest that a self-amplifying feed-forward loop among Trib3, Akt, and FoxO1 in Abeta-treated neurons induces both apoptosis and autophagy, culminating in neuron death | Tribbles Pseudokinase 3 Induces Both Apoptosis and Autophagy in Amyloid-β-induced Neuronal Death.
Saleem S, Biswas SC., Free PMC Article | 07/8/2017 |
| Diabetic rats displayed increased aortic medial thickness, excessive collagen deposition, diminished elastic fibres and reduced vascular compliance with Tribbles 3 overexpression. Trib3 silencing reversed pathological aortic remodeling in diabetic rats. | Tribbles 3: A potential player in diabetic aortic remodelling.
Ti Y, Xie GL, Wang ZH, Ding WY, Zhang Y, Zhong M, Zhang W. | 09/24/2016 |
| Findings suggest a role for TRIB3 in the development of acute insulin resistance following injury | Skeletal muscle atrogene expression and insulin resistance in a rat model of polytrauma.
Akscyn RM, Franklin JL, Gavrikova TA, Messina JL., Free PMC Article | 09/10/2016 |
| TRB3 plays an important role in stretch-induced cardiomyocyte apoptosis. | Mechanical Stretch Induces Apoptosis Regulator TRB3 in Cultured Cardiomyocytes and Volume-Overloaded Heart.
Cheng WP, Wang BW, Lo HM, Shyu KG., Free PMC Article | 04/9/2016 |
| Taken together, these results suggest that TRB3 mediates renal tubular cell apoptosis induced by protein overload, broadening our understanding of the pathogenesis of progressive proteinuric kidney diseases. | TRB3 mediates renal tubular cell apoptosis associated with proteinuria.
Wang W, Cheng J, Sun A, Lv S, Liu H, Liu X, Guan G, Liu G. | 01/16/2016 |
| Trib3 interferes with the Parkinson's disease-associated prosurvival protein Parkin to mediate death | Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models.
Aimé P, Sun X, Zareen N, Rao A, Berman Z, Volpicelli-Daley L, Bernd P, Crary JF, Levy OA, Greene LA., Free PMC Article | 10/17/2015 |
| NGF deprivation, Akt dephosphorylation/inactivation, FoxO dephosphorylation/activation and Trib3 induction are linked in a self-amplifying feed-forward loop that culminates in neuron death. | A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neurons.
Zareen N, Biswas SC, Greene LA., Free PMC Article | 06/7/2014 |
| Upregulated TRIB3 expression could induce renal fibrosis accompanied by increased phosphorylation of extracellular signal-regulated kinase. | Protection from renal fibrosis, putative role of TRIB3 gene silencing.
Ding WY, Li WB, Ti Y, Bi XP, Sun H, Wang ZH, Zhang Y, Zhang W, Zhong M. | 04/12/2014 |
| knockdown of TRIB3 inhibited, and TRIB3 overexpression enhanced, the ability of both high glucose and glucosamine to induce insulin resistance. | TRIB3 mediates glucose-induced insulin resistance via a mechanism that requires the hexosamine biosynthetic pathway.
Zhang W, Liu J, Tian L, Liu Q, Fu Y, Garvey WT., Free PMC Article | 01/18/2014 |
| TRB3 may serve as a negative regulator of pro-inflammatory cytokines and chemokines, controlling the extent of the inflammatory response. | The role of TRB3 in mast cells sensitized with monomeric IgE.
Kuo CH, Morohoshi K, Aye CC, Garoon RB, Collins A, Ono SJ. | 02/16/2013 |
| It was shown that TRIB3 impacts glucose uptake and oxidation oppositely in muscle and fat. The data implicated TRIB3 for the first time as a potent physiological regulator of insulin sensitivity and mitochondrial glucose oxidation. | Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess.
Liu J, Zhang W, Chuang GC, Hill HS, Tian L, Fu Y, Moellering DR, Garvey WT., Free PMC Article | 01/12/2013 |
| investigation into whether TRB3 plays a major role in diabetic cardiomyopathy (DCM) and the mechanisms involved: TRB3 gene silencing may exert a protective effect on DCM by improving selective insulin resistance. | TRB3 gene silencing alleviates diabetic cardiomyopathy in a type 2 diabetic rat model.
Ti Y, Xie GL, Wang ZH, Bi XL, Ding WY, Wang J, Jiang GH, Bu PL, Zhang Y, Zhong M, Zhang W., Free PMC Article | 12/17/2011 |
| Data suggest that TRIB3 inhibition improves insulin sensitivity in vivo primarily in a PPAR-gamma-dependent manner and without any change in AKT2 activity. | Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance.
Weismann D, Erion DM, Ignatova-Todorava I, Nagai Y, Stark R, Hsiao JJ, Flannery C, Birkenfeld AL, May T, Kahn M, Zhang D, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Shulman GI, Samuel VT., Free PMC Article | 08/6/2011 |
| CHOP and ATF4 might mediate PA-induced TRIB3 expression and, by extension, the suppression of IL6 activation of pro-survival kinase AKT. | UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells.
Nicoletti-Carvalho JE, Nogueira TC, Gorjão R, Bromati CR, Yamanaka TS, Boschero AC, Velloso LA, Curi R, Anhê GF, Bordin S. | 08/2/2010 |
| These data identify TRIB3 induction as a novel molecular mechanism in human insulin resistance and diabetes. | Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance.
Liu J, Wu X, Franklin JL, Messina JL, Hill HS, Moellering DR, Walton RG, Martin M, Garvey WT., Free PMC Article | 04/12/2010 |
| blocks insulin signaling by inhibiting Akt activation, which contributes to insulin resistance; may be an important factor in the occurrence and development of fatty liver | Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease.
Wang YG, Shi M, Wang T, Shi T, Wei J, Wang N, Chen XM., Free PMC Article | 01/21/2010 |
| Data demonstrated that overexpression of TRIB3 mimicked the glucotoxic effects on insulin secretion and cell growth in INS1 cells. Induction of TRIB3 synergistically enhanced high-glucose-elicited apoptosis. | TRIB3 [corrected] is implicated in glucotoxicity- and endoplasmic reticulum-stress-induced [corrected] beta-cell apoptosis.
Qian B, Wang H, Men X, Zhang W, Cai H, Xu S, Xu Y, Ye L, Wollheim CB, Lou J. | 01/21/2010 |