| Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. | Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice.
Oshima T, Kater MSJ, Huffels CFM, Wesseling EM, Middeldorp J, Hol EM, Verheijen MHG, Smit AB, Boddeke EWGM, Eggen BJL. | 04/4/2024 |
| Large-scale gene expression changes in APP/PSEN1 and GFAP mutation models exhibit high congruence with Alzheimer's disease. | Large-scale gene expression changes in APP/PSEN1 and GFAP mutation models exhibit high congruence with Alzheimer's disease.
Gammie SC, Messing A, Hill MA, Kelm-Nelson CA, Hagemann TL., Free PMC Article | 02/1/2024 |
| Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice. | Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice.
Xie YH, Jiang L, Zhang Y, Deng YH, Yang H, He Q, Zhou YN, Zhou CN, Luo YM, Liang X, Wang J, Huang DJ, Zhu L, Tang Y, Chao FL. | 01/29/2024 |
| Sex-Dependent Effects of Chronic Circadian Disruption in AbetaPP/PS1 Mice. | Sex-Dependent Effects of Chronic Circadian Disruption in AβPP/PS1 Mice.
Britz J, Ojo E, Haque N, Dhukhwa A, Hascup ER, Hascup KN, Tischkau SA., Free PMC Article | 01/29/2024 |
| Discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of APP/PS1 and MAPTxP301S transgenic mice at the early stage of Alzheimer's disease. | Discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of APP/PS1 and MAPT×P301S transgenic mice at the early stage of Alzheimer's disease.
Wang Q, Xia C, Zhu A, Bao Y, Lu J, Chen Y, Xu J, Wang B, Naman CB, Li L, Wang Q, Liu H, Liang H, Cui W. | 09/12/2023 |
| Pathogenic Abeta production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1. | Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.
Kurth V, Ogorek I, Münch C, Lopez-Rios J, Ousson S, Lehmann S, Nieweg K, Roebroek AJM, Pietrzik CU, Beher D, Weggen S., Free PMC Article | 09/1/2023 |
| Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes. | Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes.
van Heusden FC, van Nifterick AM, Souza BC, França ASC, Nauta IM, Stam CJ, Scheltens P, Smit AB, Gouw AA, van Kesteren RE., Free PMC Article | 08/30/2023 |
| Circadian rhythm sleep disorders and time-of-day-dependent memory deficiency in Presenilin1/2 conditional knockout mice with long noncoding RNA expression profiling changes. | Circadian rhythm sleep disorders and time-of-day-dependent memory deficiency in Presenilin1/2 conditional knockout mice with long noncoding RNA expression profiling changes.
Si Y, Chen J, Shen Y, Kubra S, Mei B, Qin ZS, Pan B, Meng B. | 08/10/2023 |
| Chronic Sleep Disturbances Alters Sleep Structure and Tau Phosphorylation in AbetaPP/PS1 AD Mice and Their Wild-Type Littermates. | Chronic Sleep Disturbances Alters Sleep Structure and Tau Phosphorylation in AβPP/PS1 AD Mice and Their Wild-Type Littermates.
Zhang F, Niu L, Zhong R, Li S, Le W. | 05/8/2023 |
| Disturbance of REM sleep exacerbates microglial activation in APP/PS1 mice. | Disturbance of REM sleep exacerbates microglial activation in APP/PS1 mice.
Liu S, Meng Y, Wang N, Lei Q, He L, Hong X, Li Z. | 04/21/2023 |
| Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol. | Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol.
Tousley AR, Yeh PWL, Yeh HH., Free PMC Article | 03/22/2023 |
| Presenilin and APP Regulate Synaptic Kainate Receptors. | Presenilin and APP Regulate Synaptic Kainate Receptors.
Barthet G, Moreira-de-Sá A, Zhang P, Deforges S, Castanheira J, Gorlewicz A, Mulle C., Free PMC Article | 02/15/2023 |
| PS1 Affects the Pathology of Alzheimer's Disease by Regulating BACE1 Distribution in the ER and BACE1 Maturation in the Golgi Apparatus. | PS1 Affects the Pathology of Alzheimer's Disease by Regulating BACE1 Distribution in the ER and BACE1 Maturation in the Golgi Apparatus.
Li N, Qiu Y, Wang H, Zhao J, Qing H., Free PMC Article | 01/11/2023 |
| Inhibition of circ_0004381 improves cognitive function via miR-647/PSEN1 axis in an Alzheimer disease mouse model. | Inhibition of circ_0004381 improves cognitive function via miR-647/PSEN1 axis in an Alzheimer disease mouse model.
Li N, Zhang D, Guo H, Yang Q, Li P, He Y. | 12/31/2022 |
| Treadmill exercise promotes E3 ubiquitin ligase to remove amyloid beta and P-tau and improve cognitive ability in APP/PS1 transgenic mice. | Treadmill exercise promotes E3 ubiquitin ligase to remove amyloid β and P-tau and improve cognitive ability in APP/PS1 transgenic mice.
Xu L, Li M, Wei A, Yang M, Li C, Liu R, Zheng Y, Chen Y, Wang Z, Wang K, Wang T., Free PMC Article | 10/8/2022 |
| Increased Calcium Influx through L-Type Calcium Channels in Hippocampal Neurons with Exogenous Expression of Presenilin-1 DeltaE9 Mutant. | Increased Calcium Influx through L-Type Calcium Channels in Hippocampal Neurons with Exogenous Expression of Presenilin-1 ΔE9 Mutant.
Skobeleva KV, Ryazantseva МA, Kaznacheyeva ЕV. | 05/28/2022 |
| Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis. | Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis.
Zhu ZY, Liu YD, Gong Y, Jin W, Topchiy E, Turdi S, Gao YF, Culver B, Wang SY, Ge W, Zha WL, Ren J, Pei ZH, Qin X., Free PMC Article | 03/19/2022 |
| Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice. | Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice.
Wilcox JM, Consoli DC, Tienda AA, Dixit S, Buchanan RA, May JM, Nobis WP, Harrison FE., Free PMC Article | 02/12/2022 |
| Presenilin 1 phosphorylation regulates amyloid-beta degradation by microglia. | Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia.
Ledo JH, Liebmann T, Zhang R, Chang JC, Azevedo EP, Wong E, Silva HM, Troyanskaya OG, Bustos V, Greengard P., Free PMC Article | 02/5/2022 |
| Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity. | Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity.
Lee SH, Bolshakov VY, Shen J., Free PMC Article | 01/22/2022 |
| Long-Term Sex- and Genotype-Specific Effects of (56)Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice. | Long-Term Sex- and Genotype-Specific Effects of (56)Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice.
Schroeder MK, Liu B, Hinshaw RG, Park MA, Wang S, Dubey S, Liu GG, Shi Q, Holton P, Reiser V, Jones PA, Trigg W, Di Carli MF, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA., Free PMC Article | 01/15/2022 |
| Assembly of gamma-secretase occurs through stable dimers after exit from the endoplasmic reticulum. | Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
Wouters R, Michiels C, Sannerud R, Kleizen B, Dillen K, Vermeire W, Ayala AE, Demedts D, Schekman R, Annaert W., Free PMC Article | 11/13/2021 |
| Presenilin 1 mutation likely contributes to U1 small nuclear RNA dysregulation and Alzheimer's disease-like symptoms. | Presenilin 1 mutation likely contributes to U1 small nuclear RNA dysregulation and Alzheimer's disease-like symptoms.
Cheng Z, Shang Y, Xu X, Dong Z, Zhang Y, Du Z, Lu X, Zhang T. | 11/13/2021 |
| EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways. | EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways.
Tsay HJ, Liu HK, Kuo YH, Chiu CS, Liang CC, Chung CW, Chen CC, Chen YP, Shiao YJ., Free PMC Article | 10/30/2021 |
| PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival. | PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival.
Yoon Y, Voloudakis G, Doran N, Zhang E, Dimovasili C, Chen L, Shao Z, Darmanis S, Tang C, Tang J, Wang VX, Hof PR, Robakis NK, Georgakopoulos A., Free PMC Article | 10/16/2021 |