IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model.
Cardinez C, Hao Y, Kwong K, Davies AR, Downes MB, Roberts NA, Price JD, Hernandez RA, Lovell J, Chand R, Feng ZP, Enders A, Vinuesa CG, Miraghazadeh B, Cook MC., Free PMC Article

IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity.
Avloniti M, Evangelidou M, Gomini M, Loupis T, Emmanouil M, Mitropoulou A, Tselios T, Lassmann H, Gruart A, Delgado-García JM, Probert L, Kyrargyri V., Free PMC Article

Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice.
Fisher DAC, Laranjeira ABA, Kong T, Snyder SC, Shim K, Fulbright MC, Oh ST.

Endothelial-specific loss of IKKβ disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth.
Rao S, Liu M, Iosef C, Knutsen C, Alvira CM.,

Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses.
Huang Z, Shen S, Han X, Li W, Luo W, Lin L, Xu M, Wang Y, Huang W, Wu G, Liang G., Free PMC Article

Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Zhong C, Xiong G, Yang H, Du X, Du J, Yao F, Fang W, Deng Y., Free PMC Article

Deficiency of IKKβ in neurons ameliorates Alzheimer's disease pathology in APP- and tau-transgenic mice.
Schnöder L, Quan W, Yu Y, Tomic I, Luo Q, Hao W, Peng G, Li D, Fassbender K, Liu Y.

IKKβ increases neuropilin-2 and promotes the inhibitory function of CD9(+) Bregs to control allergic diseases.
Wang Y, Deng W, Liu J, Yang Q, Chen Z, Su J, Xu J, Liang Q, Li T, Liu L, Li X.

Somatic ablation of IKKβ in liver and leukocytes is not tolerated in obese mice but hepatic IKKβ deletion improves fatty liver and insulin sensitivity.
Silva VRR, Molinaro A, Gaudi AU, Fryk E, Sardi C, Hammarlund M, Mjörnstedt F, Johansson ME, Becattini B, Jansson PA, Solinas G.

Effects of constitutively active IKKβ on cardiac development.
Sugioka S, Ikeda S, Harada M, Kishihata M, Al-Huseini I, Kimura T, Ashida N.

IKKβ Alleviates Neuron Injury in Alzheimer's Disease via Regulating Autophagy and RIPK1-Mediated Necroptosis.
Wang W, Gu X, Cheng Z, Lu X, Xie S, Liu X.

IκB Kinase-β Regulates Neutrophil Recruitment Through Activation of STAT3 Signaling in the Esophagus.
Wiles KN, Alioto CM, Hodge NB, Clevenger MH, Tsikretsis LE, Lin FTJ, Tétreault MP., Free PMC Article

The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis.
Heida A, Gruben N, Catrysse L, Koehorst M, Koster M, Kloosterhuis NJ, Gerding A, Havinga R, Bloks VW, Bongiovanni L, Wolters JC, van Dijk T, van Loo G, de Bruin A, Kuipers F, Koonen DPY, van de Sluis B., Free PMC Article

Fibroblast-specific IKK-β deficiency ameliorates angiotensin II-induced adverse cardiac remodeling in mice.
Lu W, Meng Z, Hernandez R, Zhou C., Free PMC Article

TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly.
Samir P, Place DE, Malireddi RKS, Kanneganti TD.

IKK2/NF-κB Activation in Astrocytes Reduces amyloid β Deposition: A Process Associated with Specific Microglia Polarization.
Yang S, Magnutzki A, Alami NO, Lattke M, Hein TM, Scheller JS, Kröger C, Oswald F, Yilmazer-Hanke D, Wirth T, Baumann B., Free PMC Article

IL-36α Exerts Proinflammatory Effects in Aspergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB.
Niu Y, Ren C, Peng X, Li C, Xu Q, Hu L, Zhang Z, Zhao G, Lin J., Free PMC Article

Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation.
Fischer KC, Daunt CP, Tremblay CS, Dias S, Vince JE, Jabbour AM., Free PMC Article

Ikk2-mediated inflammatory activation of arterial endothelial cells promotes the development and progression of atherosclerosis.
Mussbacher M, Salzmann M, Haigl B, Basílio J, Hochreiter B, Gleitsmann V, Moser B, Hoesel B, Suur BE, Puhm F, Ungerböck C, Kuttke M, Forteza MJ, Binder CJ, Ketelhuth DFJ, Assinger A, Schmid JA.

Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKβ-Deficient Osteoblasts.
Hao Q, Liu Z, Lu L, Zhang L, Zuo L., Free PMC Article

Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis.
Saber S, Ghanim AMH, El-Ahwany E, El-Kader EMA.

Small heat shock protein CRYAB inhibits intestinal mucosal inflammatory responses and protects barrier integrity through suppressing IKKβ activity.
Xu W, Guo Y, Huang Z, Zhao H, Zhou M, Huang Y, Wen D, Song J, Zhu Z, Sun M, Liu CY, Chen Y, Cui L, Wang X, Liu Z, Yang Y, Du P.

IKKβ slows Huntington's disease progression in R6/1 mice.
Ochaba J, Fote G, Kachemov M, Thein S, Yeung SY, Lau AL, Hernandez S, Lim RG, Casale M, Neel MJ, Monuki ES, Reidling J, Housman DE, Thompson LM, Steffan JS., Free PMC Article

Distinct roles for IκB kinases alpha and beta in regulating pulmonary endothelial angiogenic function during late lung development.
Iosef C, Liu M, Ying L, Rao SP, Concepcion KR, Chan WK, Oman A, Alvira CM., Free PMC Article

IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation.
Sui Y, Liu Z, Park SH, Thatcher SE, Zhu B, Fernandez JP, Molina H, Kern PA, Zhou C., Free PMC Article