| Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2 and ADAMTS-12. | Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2 and ADAMTS-12.
Mohamedi Y, Fontanil T, Vega JA, Cobo T, Cal S, Obaya ÁJ., Free PMC Article | 03/12/2024 |
| Fibulin-2: A potential regulator of immune dysfunction after bone trauma. | Fibulin-2: A potential regulator of immune dysfunction after bone trauma.
Li S, Jiang H, Wang S, Li Y, Guo D, Zhan J, Li Q, Meng H, Chen A, Chen L, Dai X, Li X, Xing W, Li L, Fei J., Free PMC Article | 05/31/2023 |
| Fibulin 2 Is Hypermethylated and Suppresses Tumor Cell Proliferation through Inhibition of Cell Adhesion and Extracellular Matrix Genes in Non-Small Cell Lung Cancer. | Fibulin 2 Is Hypermethylated and Suppresses Tumor Cell Proliferation through Inhibition of Cell Adhesion and Extracellular Matrix Genes in Non-Small Cell Lung Cancer.
Ma Y, Nenkov M, Schröder DC, Abubrig M, Gassler N, Chen Y., Free PMC Article | 12/18/2021 |
| High FBLN2 expression is associated with cognitive impairment. | Up-regulated miR-192-5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2-mediated TGF-β1 signaling pathway.
Tang CZ, Yang JT, Liu QH, Wang YR, Wang WS. | 07/13/2019 |
| Fibulin 2 localized to the RPE, choroid, and Bruch's membrane. Knockout mice had a significantly reduced scotopic A response by 1 month of age, when compared to their wild-type counterparts, which remained throughout life and only declined as a result of normal aging. The functional decline was associated with reduced number of photoreceptor cells. | Role of Fibulins 2 and 5 in Retinal Development and Maintenance.
Ikelle L, Naash MI, Al-Ubaidi MR. | 05/11/2019 |
| Our study indicates that Ang II cannot induce TGF-beta activation without fibulin-2 and that fibulin-2 has an essential role in Ang II-induced TGF-beta signaling and subsequent myocardial fibrosis. Fibulin-2 can be considered as a critical regulator of TGF-beta that induces myocardial fibrosis. | Fibulin-2 is essential for angiotensin II-induced myocardial fibrosis mediated by transforming growth factor (TGF)-β.
Khan SA, Dong H, Joyce J, Sasaki T, Chu ML, Tsuda T., Free PMC Article | 06/24/2017 |
| These findings demonstrate a prominent role for alpha3beta1 in immortalized/transformed keratinocytes in regulating fibulin-2 and other genes that promote matrix remodeling and invasion. | Regulation of fibulin-2 gene expression by integrin α3β1 contributes to the invasive phenotype of transformed keratinocytes.
Missan DS, Chittur SV, DiPersio CM., Free PMC Article | 12/20/2014 |
| FBLN2 and VCAN were both preferentially expressed in the mammary gland during times of epithelial expansion in TEB-enriched tissue and co-localised specifically in cap cell. | Fibulin-2 is involved in early extracellular matrix development of the outgrowing mouse mammary epithelium.
Olijnyk D, Ibrahim AM, Ferrier RK, Tsuda T, Chu ML, Gusterson BA, Stein T, Morris JS. | 11/22/2014 |
| integrin alpha3beta1 has a role in basement membrane stability through fibulin-2 induction, both in neonatal skin and in adult wounds | Reduced fibulin-2 contributes to loss of basement membrane integrity and skin blistering in mice lacking integrin α3β1 in the epidermis.
Longmate WM, Monichan R, Chu ML, Tsuda T, Mahoney MG, DiPersio CM., Free PMC Article | 07/12/2014 |
| levels of fibulin 2 dramatically increased in the retinal pigment epithelium following retinal detachment, suggesting a direct role for fibulin 2 in the re-attachment of the retina to the retinal pigment epithelium. | Fibulin 2, a tyrosine O-sulfated protein, is up-regulated following retinal detachment.
Kanan Y, Brobst D, Han Z, Naash MI, Al-Ubaidi MR., Free PMC Article | 06/28/2014 |
| Data conclude that fibulin-2 is a driver of malignant progression in lung adenocarcinoma and plays an unexpected role in collagen cross-linking and tumor cell adherence to collagen. | Fibulin-2 is a driver of malignant progression in lung adenocarcinoma.
Baird BN, Schliekelman MJ, Ahn YH, Chen Y, Roybal JD, Gill BJ, Mishra DK, Erez B, O'Reilly M, Yang Y, Patel M, Liu X, Thilaganathan N, Larina IV, Dickinson ME, West JL, Gibbons DL, Liu DD, Kim MP, Hicks JM, Wistuba II, Hanash SM, Kurie JM., Free PMC Article | 01/18/2014 |
| Fibulin-2 is essential for angiotensin II-induced transforming growth factor-beta-mediated cardiac hypertrophy via enhanced TGF-beta activation. | Fibulin-2 deficiency attenuates angiotensin II-induced cardiac hypertrophy by reducing transforming growth factor-β signalling.
Zhang H, Wu J, Dong H, Khan SA, Chu ML, Tsuda T., Free PMC Article | 12/21/2013 |
| absence of fibulin-2 results in decreased up-regulation of TGF-beta signaling after MI and protects against ventricular dysfunction. | Loss of fibulin-2 protects against progressive ventricular dysfunction after myocardial infarction.
Tsuda T, Wu J, Gao E, Joyce J, Markova D, Dong H, Liu Y, Zhang H, Zou Y, Gao F, Miller T, Koch W, Ma X, Chu ML., Free PMC Article | 04/28/2012 |
| Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina during postnatal development by directing the assembly of elastic fibers, and are responsible for maintenance of the adult vessel wall after injury | Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury.
Chapman SL, Sicot FX, Davis EC, Huang J, Sasaki T, Chu ML, Yanagisawa H., Free PMC Article | 01/21/2010 |
| fibulin-2 is not required for mouse development and elastic fiber formation and suggest possible functional redundancy between fibulin-1 and fibulin-2. | Fibulin-2 is dispensable for mouse development and elastic fiber formation.
Sicot FX, Tsuda T, Markova D, Klement JF, Arita M, Zhang RZ, Pan TC, Mecham RP, Birk DE, Chu ML., Free PMC Article | 01/21/2010 |
| short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2 | Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.
Sasaki T, Göhring W, Mann K, Brakebusch C, Yamada Y, Fässler R, Timpl R. | 01/21/2010 |
| The alterations in elastogenesis associated with increased fibulin-2 in hypodermal connective tissues and decreased fibulin-5 at the hypodermal M-CT interface suggest that these proteins mediate the effect of Tsk-fibrillin-1 on elastogenesis. | Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering.
Lemaire R, Korn JH, Schiemann WP, Lafyatis R. | 01/21/2010 |