| The host antiviral protein SAMHD1 suppresses NF-kappaB activation by interacting with the IKK complex during inflammatory responses and viral infection. | The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection.
Yang H, Espada CE, Phillips S, Martinez N, Kenney AD, Yount JS, Xiong Y, Wu L., Free PMC Article | 07/3/2023 |
| IL-1beta stimulates a novel, IKKalpha -dependent, NIK -independent activation of non-canonical NFkappaB signalling. | IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling.
McIntosh K, Khalaf YH, Craig R, West C, McCulloch A, Waghmare A, Lawson C, Chan EYW, Mackay S, Paul A, Plevin R. | 05/15/2023 |
| IKKalpha kinase silencing increases doxorubicin-induced apoptosis through regulation of oxidative DNA damage response in colon cancer cells. | IKKα kinase silencing increases doxorubicin-induced apoptosis through regulation of oxidative DNA damage response in colon cancer cells.
Gao J, Zhu L. | 04/14/2023 |
| The inhibitor of kappaB kinase beta (IKKbeta) phosphorylates IkappaBalpha twice in a single binding event through a sequential mechanism. | The inhibitor of κB kinase β (IKKβ) phosphorylates IκBα twice in a single binding event through a sequential mechanism.
Stephenson AA, Taggart DJ, Xu G, Fowler JD, Wu H, Suo Z., Free PMC Article | 02/4/2023 |
| Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. | Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer.
Patel M, Pennel KAF, Quinn JA, Hood H, Chang DK, Biankin AV, Rebus S, Roseweir AK, Park JH, Horgan PG, McMillan DC, Edwards J., Free PMC Article | 06/18/2022 |
| Enterovirus 2C Protein Suppresses IKKalpha Phosphorylation by Recruiting IKKbeta and IKKalpha into Viral Inclusion Bodies. | Enterovirus 2C Protein Suppresses IKKα Phosphorylation by Recruiting IKKβ and IKKα into Viral Inclusion Bodies.
Ji L, Yang E, He S, Jin Y, Chen D. | 03/19/2022 |
| Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor B kinase alpha (IKKalpha). | Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor 𝛋B kinase alpha (IKKα).
Bainter W, Lougaris V, Wallace JG, Badran Y, Hoyos-Bachiloglu R, Peters Z, Wilkie H, Das M, Janssen E, Beano A, Farhat KB, Kam C, Bercich L, Incardona P, Villanacci V, Bondioni MP, Meini A, Baronio M, Abarzua P, Parolini S, Tabellini G, Maio S, Schmidt B, Goldsmith JD, Murphy G, Hollander G, Plebani A, Chou J, Geha RS., Free PMC Article | 03/5/2022 |
| IKKalpha plays a major role in canonical NF-kappaB signalling in colorectal cells. | IKKα plays a major role in canonical NF-κB signalling in colorectal cells.
Prescott JA, Balmanno K, Mitchell JP, Okkenhaug H, Cook SJ., Free PMC Article | 02/19/2022 |
| Naa10p and IKKalpha interaction regulates EMT in oral squamous cell carcinoma via TGF-beta1/Smad pathway. | Naa10p and IKKα interaction regulates EMT in oral squamous cell carcinoma via TGF-β1/Smad pathway.
Lv S, Luo T, Yang Y, Li Y, Yang J, Xu J, Zheng J, Zeng Y., Free PMC Article | 02/5/2022 |
| CRSP8 promotes thyroid cancer progression by antagonizing IKKalpha-induced cell differentiation. | CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation.
Liao Y, Hua Y, Li Y, Zhang C, Yu W, Guo P, Zou K, Li W, Sun Y, Wang R, Zuo Y, Sui S, Tian C, Hao J, Chen M, Hu S, Chen M, Long Q, Wang X, Zou L, Xie F, Guo W, Deng W., Free PMC Article | 01/29/2022 |
| IKKalpha mediates UVB-induced cell apoptosis by regulating p53 pathway activation. | IKKα mediates UVB-induced cell apoptosis by regulating p53 pathway activation.
Wang H, Zhang M, Xu X, Hou S, Liu Z, Chen X, Zhang C, Xu H, Wu L, Liu K, Song L. | 11/22/2021 |
| Long Non-Coding RNA NKILA Reduces Oral Squamous Cell Carcinoma Development Through the NF-KappaB Signaling Pathway. | Long Non-Coding RNA NKILA Reduces Oral Squamous Cell Carcinoma Development Through the NF-KappaB Signaling Pathway.
Hu D, Zhong T, Dai Q., Free PMC Article | 11/6/2021 |
| The inflammatory kinase IKKalpha phosphorylates and stabilizes c-Myc and enhances its activity. | The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity.
Moser B, Hochreiter B, Basílio J, Gleitsmann V, Panhuber A, Pardo-Garcia A, Hoesel B, Salzmann M, Resch U, Noreen M, Schmid JA., Free PMC Article | 08/14/2021 |
| Oxidative stress-induced DNA damage and repair in primary human osteoarthritis chondrocytes: focus on IKKalpha and the DNA Mismatch Repair System. | Oxidative stress-induced DNA damage and repair in primary human osteoarthritis chondrocytes: focus on IKKα and the DNA Mismatch Repair System.
Neri S, Guidotti S, Bini C, Pelotti S, D'Adamo S, Minguzzi M, Platano D, Santi S, Mariani E, Cattini L, Borzì RM. | 07/3/2021 |
| Association of CHUK gene polymorphism and ischemic stroke in the Han Chinese population. | Association of CHUK gene polymorphism and ischemic stroke in the Han Chinese population.
Huang J, Wei Q, Liang B, Shen T, Wu Y, Chen Z, Yang J, Gu L. | 06/26/2021 |
| Human Caspase 12 Enhances NF-kappaB Activity through Activation of IKK in Nasopharyngeal Carcinoma Cells. | Human Caspase 12 Enhances NF-κB Activity through Activation of IKK in Nasopharyngeal Carcinoma Cells.
Chow SE, Chien HT, Chu WK, Lin V, Shen TH, Huang SF., Free PMC Article | 05/29/2021 |
| The potential function of IKKalpha in gastric precancerous lesion via mediating Maspin. | The potential function of IKKα in gastric precancerous lesion via mediating Maspin.
Wang N, Chang LL. | 05/29/2021 |
| Selective degradation of IKKalpha by autophagy is essential for arsenite-induced cancer cell apoptosis. | Selective degradation of IKKα by autophagy is essential for arsenite-induced cancer cell apoptosis.
Tan Q, Zou S, Jin R, Hu Y, Xu H, Wang H, Ding M, Hu M, Wei C, Song L., Free PMC Article | 04/13/2021 |
| Canonical, Non-Canonical and Atypical Pathways of Nuclear Factor small ka, Cyrillicb Activation in Preeclampsia. | Canonical, Non-Canonical and Atypical Pathways of Nuclear Factor кb Activation in Preeclampsia.
Sakowicz A, Bralewska M, Pietrucha T, Habrowska-Górczyńska DE, Piastowska-Ciesielska AW, Gach A, Rybak-Krzyszkowska M, Witas PJ, Huras H, Grzesiak M, Biesiada L., Free PMC Article | 02/20/2021 |
| Determining the prognostic significance of IKKalpha in prostate cancer. | Determining the prognostic significance of IKKα in prostate cancer.
Montes M, MacKenzie L, McAllister MJ, Roseweir A, McCall P, Hatziieremia S, Underwood MA, Boyd M, Paul A, Plevin R, MacKay SP, Edwards J. | 01/16/2021 |
| The role and function of IkappaKalpha/beta in monocyte impairment. | The role and function of IκKα/β in monocyte impairment.
Galbraith NJ, Gardner SA, Walker SP, Trainor P, Carter JV, Bishop C, Sarojini H, O'Brien SJ, Bhatnagar A, Polk HC Jr, Galandiuk S., Free PMC Article | 12/5/2020 |
| The anti-tumor function of the IKK inhibitor PS1145 and high levels of p65 and KLF4 are associated with the drug resistance in nasopharyngeal carcinoma cells. | The anti-tumor function of the IKK inhibitor PS1145 and high levels of p65 and KLF4 are associated with the drug resistance in nasopharyngeal carcinoma cells.
Lung HL, Kan R, Chau WY, Man OY, Mak NK, Fong CH, Shuen WH, Tsao SW, Lung ML., Free PMC Article | 10/24/2020 |
| Reduced expression of adenomatous polyposis coli (Apc) gene and IkappaB kinase alpha (IkappaBalpha), and increased expression of NF-kappaB p65 were found in Intracranial aneurysm (IA) tissues. | Apc gene suppresses intracranial aneurysm formation and rupture through inhibiting the NF-κB signaling pathway mediated inflammatory response.
Lai XL, Deng ZF, Zhu XG, Chen ZH., Free PMC Article | 02/22/2020 |
| data indicate that the IKKs restrict infection but HCMV targets their signaling to modulate the cellular inflammatory environment. | The IκB Kinases Restrict Human Cytomegalovirus Infection.
Goodwin CM, Munger J., Free PMC Article | 02/1/2020 |
| IKKalpha(p45) is rapidly activated by DNA damage independent of ATM-ATR, but dependent on BRAF-TAK1-p38-MAPK, and is required for robust ATM activation and efficient DNA repair. | IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
Colomer C, Margalef P, Villanueva A, Vert A, Pecharroman I, Solé L, González-Farré M, Alonso J, Montagut C, Martinez-Iniesta M, Bertran J, Borràs E, Iglesias M, Sabidó E, Bigas A, Boulton SJ, Espinosa L., Free PMC Article | 02/1/2020 |