| Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma. | Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma.
Luomala L, Mattila K, Vainio P, Nisén H, Pellinen T, Lohi J, Laajala TD, Järvinen P, Koskenniemi AR, Jaakkola P, Mirtti T., Free PMC Article | 02/29/2024 |
| EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-kappaB signalling activation independent of hydroxylase activity. | EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity.
Cai F, Yang X, Ma G, Wang P, Zhang M, Zhang N, Zhang R, Liang H, Nie Y, Dong C, Deng J., | 02/22/2024 |
| E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression. | E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression.
Zhou P, Peng X, Tang S, Zhang K, Tan Z, Li D, Shen L, Peng J, Yang L. | 04/19/2023 |
| PHD3 as a Prognosis Marker and its Relationship with Immune Infiltration in Lung Adenocarcinoma. | PHD3 as a Prognosis Marker and its Relationship with Immune Infiltration in Lung Adenocarcinoma.
Wang L, Zhong Y, Wang G, An H, Gao Q, Ye Y. | 10/29/2022 |
| Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth. | Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth.
Jin Y, Pan Y, Zheng S, Liu Y, Xu J, Peng Y, Zhang Z, Wang Y, Xiong Y, Xu L, Mu K, Chen S, Zheng F, Yuan Y, Fu J., Free PMC Article | 05/7/2022 |
| PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle. | PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle.
Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Rombold O, Agar NYR, Goodyear LJ, Shaw RJ, Gygi SP, Auwerx J, Haigis MC., Free PMC Article | 11/13/2021 |
| USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bbeta via deubiquitinating EGLN3. | USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3.
Chen W, Song J, Liu S, Tang B, Shen L, Zhu J, Fang S, Wu F, Zheng L, Qiu R, Chen C, Gao Y, Tu J, Zhao Z, Ji J., Free PMC Article | 10/2/2021 |
| Development of a colorimetric alpha-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins. | Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins.
Wong SJ, Ringel AE, Yuan W, Paulo JA, Yoon H, Currie MA, Haigis MC., Free PMC Article | 09/11/2021 |
| Decreased prolyl hydroxylase 3 mRNA expression in oncocytomas compared with clear cell renal cell carcinoma. | Decreased prolyl hydroxylase 3 mRNA expression in oncocytomas compared with clear cell renal cell carcinoma.
Kampantais S, Kounatidis I, Kotoula V, Vakalopoulos I, Gkagkalidis K, Dimitriadis G. | 08/28/2021 |
| Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo. | Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo.
Zacharias NM, Wang L, Maity T, Li L, Millward SW, Karam JA, Wood CG, Navai N., Free PMC Article | 05/8/2021 |
| Interaction among oncogenic miR-31, EGLN3 down-regulation, and inflammation was documented in human esophageal squamous cell carcinoma tissues. | Abrogation of esophageal carcinoma development in miR-31 knockout rats.
Fong LY, Taccioli C, Palamarchuk A, Tagliazucchi GM, Jing R, Smalley KJ, Fan S, Altemus J, Fiehn O, Huebner K, Farber JL, Croce CM., Free PMC Article | 07/18/2020 |
| This is the first crystal report of PHD3/PKM2 complex as well as this study demonstrates a direct physical binding through protein-protein interaction. | Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex.
Kumar S, Patel AK. | 06/13/2020 |
| EGLN3 polymorphism is associated with High-Altitude Polycythemia. | Whole-Genome Sequencing Identifies the Egl Nine Homologue 3 (egln3/phd3) and Protein Phosphatase 1 Regulatory Inhibitor Subunit 2 (PPP1R2P1) Associated with High-Altitude Polycythemia in Tibetans at High Altitude.
Gesang L, Gusang L, Dawa C, Gesang G, Li K., Free PMC Article | 05/2/2020 |
| The authors did not detect prolyl-hydroxylase activity on any reported non-HIF protein or peptide, using conditions supporting robust HIF-alpha hydroxylation. | Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates.
Cockman ME, Lippl K, Tian YM, Pegg HB, Figg WD Jnr, Abboud MI, Heilig R, Fischer R, Myllyharju J, Schofield CJ, Ratcliffe PJ., Free PMC Article | 02/22/2020 |
| PHD3 regulates p53 stability through hydroxylation of p53 at proline 359. | PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.
Rodriguez J, Herrero A, Li S, Rauch N, Quintanilla A, Wynne K, Krstic A, Acosta JC, Taylor C, Schlisio S, von Kriegsheim A., Free PMC Article | 12/14/2019 |
| By targeting EGLN3, miR-1205 has an oncogenic role and may contribute to the genetic risk of castration-resistant prostate cancer. | MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancer.
Wang Y, Li X, Liu W, Li B, Chen D, Hu F, Wang L, Liu XM, Cui R, Liu R., Free PMC Article | 12/14/2019 |
| PHD3 maintains high HIF2A mRNA levels in clear cell renal cell carcinoma | Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma.
Miikkulainen P, Högel H, Seyednasrollah F, Rantanen K, Elo LL, Jaakkola PM., Free PMC Article | 05/25/2019 |
| Acetylation-mediated Siah2 stabilization enhances PHD3 degradation in Helicobacter pylori-infected gastric epithelial cancer cells. | Acetylation-mediated Siah2 stabilization enhances PHD3 degradation in Helicobacter pylori-infected gastric epithelial cancer cells.
Kokate SB, Dixit P, Das L, Rath S, Roy AD, Poirah I, Chakraborty D, Rout N, Singh SP, Bhattacharyya A. | 04/6/2019 |
| This study links the oxygen sensor PHD3 to metastasis and drug resistance in cancer, with implications for therapeutic improvement by targeting this system. | PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα.
Dopeso H, Jiao HK, Cuesta AM, Henze AT, Jurida L, Kracht M, Acker-Palmer A, Garvalov BK, Acker T. | 03/23/2019 |
| PHD3 overexpression may reduce the migratory and invasive capacity of gastric cancer cells, and inhibit the formation of tumor vasculature via negatively regulating HIF1A, which has been revealed to control VEGF transcription. | PHD3 affects gastric cancer progression by negatively regulating HIF1A.
Xia YJ, Jiang XT, Jiang SB, He XJ, Luo JG, Liu ZC, Wang L, Tao HQ, Chen JZ. | 06/9/2018 |
| provides a rationale for targeting the PHD3-mediated regulation of the adaptive cellular hypoxic response in MM and suggests that targeting the O2-sensing pathway, alone or in combination with other anti-myeloma chemotherapeutics, may have clinical efficacy | Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis.
Gastelum G, Poteshkina A, Veena M, Artiga E, Weckstein G, Frost P., Free PMC Article | 12/30/2017 |
| These results indicate that the immunohistochemistry analysis of the protein expression of PDK1, PHD3, and HIF-1alpha defines the hypoxic status of Neuroblastoma tumors. | Immunohistochemical analysis of PDK1, PHD3 and HIF-1α expression defines the hypoxic status of neuroblastoma tumors.
Ognibene M, Cangelosi D, Morini M, Segalerba D, Bosco MC, Sementa AR, Eva A, Varesio L., Free PMC Article | 12/2/2017 |
| These findings indicate that downregulation of PHD3 and FIH in HCC is associated with more aggressive tumor behavior and a poor prognosis in hepatocellular carcinoma | Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma.
Ma M, Hua S, Li G, Wang S, Cheng X, He S, Wu P, Chen X., Free PMC Article | 10/7/2017 |
| PHD3 loss in cancer enables metabolic reliance on fatty acid oxidation via deactivation of ACC2. | PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.
German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG Jr, Haigis MC., Free PMC Article | 09/9/2017 |
| Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases. | Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases.
Chan MC, Ilott NE, Schödel J, Sims D, Tumber A, Lippl K, Mole DR, Pugh CW, Ratcliffe PJ, Ponting CP, Schofield CJ., Free PMC Article | 05/20/2017 |