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    WFDC2 WAP four-disulfide core domain 2 [ Homo sapiens (human) ]

    Gene ID: 10406, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Prognostic value of HE4 in advanced-stage, high-grade serous ovarian cancer: Analysis of HE4 kinetics during NACT, predicting surgical outcome and recurrence in comparison to CA125.

    Prognostic value of HE4 in advanced-stage, high-grade serous ovarian cancer: Analysis of HE4 kinetics during NACT, predicting surgical outcome and recurrence in comparison to CA125.
    AlSomairi A, Himayda S, Altelmesani A, Lee YJ, Lee JY.

    03/1/2024
    Human Epididymis Protein 4 (HE4) and Cancer Antigen 125 (CA125) for Prediction of Optimal Primary Surgery in Non-Mucinous Epithelial Ovarian Cancer.

    Human Epididymis Protein 4 (HE4) and Cancer Antigen 125 (CA125) for Prediction of Optimal Primary Surgery in Non-Mucinous Epithelial Ovarian Cancer.
    Promchit K, Oranratanaphan S., Free PMC Article

    02/21/2024
    Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy.

    Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy.
    Luo HL, He C, Xue H, Li M, Ji L, Xia Y.

    01/12/2024
    Elevated level of serum human epididymis protein 4 (HE4) predicts disease severity and mortality in COVID-19 pneumonia.

    Elevated level of serum human epididymis protein 4 (HE4) predicts disease severity and mortality in COVID-19 pneumonia.
    Sütő R, Pócsi M, Szabó Z, Fejes Z, Ivády G, Kerekes G, Fagyas M, Nagy A, Szentkereszty Z, Kappelmayer J, Nagy B Jr., Free PMC Article

    12/27/2023
    Combination of serum CST1 and HE4 for early diagnosis of endometrial cancer.

    Combination of serum CST1 and HE4 for early diagnosis of endometrial cancer.
    Zhong W, Liu Y, Zhang L, Zhuang W, Chen J, Huang Z, Zheng Y, Huang Y., Free PMC Article

    12/18/2023
    Effect of Serum Level of Human Epididymis Protein 4 and Interleukin-6 as Biomarkers in Patients with Adnexal Mass.

    Effect of Serum Level of Human Epididymis Protein 4 and Interleukin-6 as Biomarkers in Patients with Adnexal Mass.
    Hameed S, Abdulqader Jasim H, Sharief M., Free PMC Article

    10/28/2023
    Diagnostic value of serum human epididymis protein 4, carbohydrate antigen 125 and their combination in endometrial cancer: A meta-analysis.

    Diagnostic value of serum human epididymis protein 4, carbohydrate antigen 125 and their combination in endometrial cancer: A meta-analysis.
    Wu Q, Bai SN, Song LY, Wu WF, Han LN., Free PMC Article

    08/25/2023
    The Utility of Preoperative Serum CA125 Combined with HE4 to Predict Lymph Node Metastasis in Endometrial Cancer.

    The Utility of Preoperative Serum CA125 Combined with HE4 to Predict Lymph Node Metastasis in Endometrial Cancer.
    Prueksaritanond N, Angsathapon S, Insin P.

    03/30/2023
    Human epididymis protein 4 as a clinical biomarker in identifying interstitial lung disease in patients with idiopathic inflammatory myopathies.

    Human epididymis protein 4 as a clinical biomarker in identifying interstitial lung disease in patients with idiopathic inflammatory myopathies.
    Sun F, Zhao J, Li Y, Wang H, Cao X, Cheng W, Chen J.

    02/28/2023
    Secreted proteins MDK, WFDC2, and CXCL14 as candidate biomarkers for early diagnosis of lung adenocarcinoma.

    Secreted proteins MDK, WFDC2, and CXCL14 as candidate biomarkers for early diagnosis of lung adenocarcinoma.
    Li J, Li J, Hao H, Lu F, Wang J, Ma M, Jia B, Zhuo M, Wang J, Chi Y, Zhai X, Wang Y, Wu M, An T, Zhao J, Yang F, Wang Z., Free PMC Article

    02/4/2023
    Evaluation of HE4 as a prognostic biomarker in uterine cervical cancer.

    Evaluation of HE4 as a prognostic biomarker in uterine cervical cancer().
    Dubey H, Ranjan A, Durai J, Khan MA, Lakshmy R, Khurana S, Gupta S, Meena J, Ray MD, Tanwar P, Chopra A, Tiwari S.

    02/4/2023
    HE4 as a serum biomarker for the diagnosis of pelvic masses: a prospective, multicenter study in 965 patients.

    HE4 as a serum biomarker for the diagnosis of pelvic masses: a prospective, multicenter study in 965 patients.
    Braicu EI, Krause CL, Torsten U, Mecke H, Richter R, Hellmeyer L, Lanowska M, Müller B, Koch E, Boenneß-Zaloum J, Ames K, Chekerov R, Hasenbein K, Zimmermann M, Mangler M, Chen F, Tauber R, Sehouli J., Free PMC Article

    08/13/2022
    Can serum human epididymis protein 4 (HE4) support the decision to refer a patient with an ovarian mass to an oncology hospital?

    Can serum human epididymis protein 4 (HE4) support the decision to refer a patient with an ovarian mass to an oncology hospital?
    Lof P, van de Vrie R, Korse CM, van Gent MDJM, Mom CH, Rosier-van Dunné FMF, van Baal WM, Verhoeve HR, Hermsen BBJ, Verbruggen MB, Hemelaar M, van de Swaluw AMG, Knipscheer HC, Huirne JAF, Westenberg SM, van der Noort V, Amant F, van den Broek D, Lok CAR.

    07/30/2022
    HE4 is associated with clinical risk prognostic factors and survival outcome in primary fallopian tube carcinoma patients.

    HE4 is associated with clinical risk prognostic factors and survival outcome in primary fallopian tube carcinoma patients.
    Mi D, Zhang Y, Chen S.

    07/16/2022
    Serum HE4 is associated with clinical prognostic factors and survival outcome in female patients with primary peritoneal carcinoma.

    Serum HE4 is associated with clinical prognostic factors and survival outcome in female patients with primary peritoneal carcinoma.
    Mi D, Zhang Y, Chen S.

    07/16/2022
    Human epididymis protein 4 is associated with severity and poor prognosis of connective tissue disease-associated interstitial lung disease with usual interstitial pneumonia pattern.

    Human epididymis protein 4 is associated with severity and poor prognosis of connective tissue disease-associated interstitial lung disease with usual interstitial pneumonia pattern.
    Meng K, Tian M, Gui X, Xie M, Gao Y, Shi S, Zhao T, Xiao Y, Cai H, Ding J.

    07/2/2022
    Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease.

    Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease.
    Zhan Y, Chen J, Wu J, Gu Y, Huang Q, Deng Z, Chen S, Wu X, Lv Y, Zeng Z, Xie J., Free PMC Article

    06/11/2022
    A bioinformatic analysis of WFDC2 (HE4) expression in high grade serous ovarian cancer reveals tumor-specific changes in metabolic and extracellular matrix gene expression.

    A bioinformatic analysis of WFDC2 (HE4) expression in high grade serous ovarian cancer reveals tumor-specific changes in metabolic and extracellular matrix gene expression.
    James NE, Gura M, Woodman M, Freiman RN, Ribeiro JR., Free PMC Article

    05/28/2022
    Recurrence monitoring for ovarian cancer using a cell phone-integrated paper device to measure the ovarian cancer biomarker HE4/CRE ratio in urine.

    Recurrence monitoring for ovarian cancer using a cell phone-integrated paper device to measure the ovarian cancer biomarker HE4/CRE ratio in urine.
    Kight EC, Hussain I, Bowden AK, Haselton FR., Free PMC Article

    01/29/2022
    Serum HE4 and CA125 combined to predict and monitor recurrence of type II endometrial carcinoma.

    Serum HE4 and CA125 combined to predict and monitor recurrence of type II endometrial carcinoma.
    Quan Q, Liao Q, Yin W, Zhou S, Gong S, Mu X., Free PMC Article

    01/29/2022
    Serum Human Epididymis Protein-4 (HE4) - A novel Approach to Differentiate Malignant Frombenign Breast Tumors.

    Serum Human Epididymis Protein-4 (HE4) - A novel Approach to Differentiate Malignant Frombenign Breast Tumors.
    Sai Baba KSS, Rehman MA, Pradeep Kumar J, Fatima M, Raju GSN, Uppin SG, Mohammed N., Free PMC Article

    01/22/2022
    Determination of the Upper Reference Limit of Human Epididymis Secretory Protein 4 (HE4) in Healthy Male Individuals and Correlation with Renal and Fertility Markers.

    Determination of the Upper Reference Limit of Human Epididymis Secretory Protein 4 (HE4) in Healthy Male Individuals and Correlation with Renal and Fertility Markers.
    Schirinzi A, Cazzolla AP, Mascolo E, Palmieri G, Pesce F, Gesualdo L, Santacroce L, Ballini A, Lovero R, Di Serio F.

    12/4/2021
    Role of Human Epididymis Protein 4 (HE4) in Determining Survival of Patients With Endometrial Cancer: A Meta-Analysis.

    Role of Human Epididymis Protein 4 (HE4) in Determining Survival of Patients With Endometrial Cancer: A Meta-Analysis.
    He Y, Wang J, Ma CX, Kang YH., Free PMC Article

    11/27/2021
    High levels of human epididymis protein 4 mRNA and protein expression are associated with chemoresistance and a poor prognosis in pancreatic cancer.

    High levels of human epididymis protein 4 mRNA and protein expression are associated with chemoresistance and a poor prognosis in pancreatic cancer.
    Ohkuma R, Yada E, Ishikawa S, Komura D, Kubota Y, Hamada K, Horiike A, Ishiguro T, Hirasawa Y, Ariizumi H, Shida M, Watanabe M, Onoue R, Ando K, Tsurutani J, Yoshimura K, Sasada T, Aoki T, Murakami M, Norose T, Ohike N, Takimoto M, Kobayashi S, Tsunoda T, Wada S., Free PMC Article

    11/22/2021
    Elevated Serum Human Epididymis Protein 4 Is Associated With Disease Activity and Systemic Involvements in Primary Sjogren's Syndrome.

    Elevated Serum Human Epididymis Protein 4 Is Associated With Disease Activity and Systemic Involvements in Primary Sjögren's Syndrome.
    Chen J, Sun F, Bao H, Liang L, Zhan M, Yao H, He J, Liu Y., Free PMC Article

    11/6/2021
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