| ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells. | ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells.
Deng T, Xie L, Xiaofang C, Zhang Z, Xiao Y, Peng Y, Yin L, Fu Y, Li X., Free PMC Article | 03/1/2024 |
| the present study provides preclinical and clinical data indicating that lower RANBP9 protein levels might be used, after perspective validation, as a biomarker predictive of response of non-small cell lung cancer to platinum based compounds | RANBP9 affects cancer cells response to genotoxic stress and its overexpression is associated with worse response to platinum in NSCLC patients.
Tessari A, Parbhoo K, Pawlikowski M, Fassan M, Rulli E, Foray C, Fabbri A, Embrione V, Ganzinelli M, Capece M, Campbell MJ, Broggini M, La Perle K, Farina G, Cole S, Marabese M, Hernandez M, Amann JM, Pruneri G, Carbone DP, Garassino MC, Croce CM, Palmieri D, Coppola V., Free PMC Article | 03/2/2019 |
| review provides a complete guide on RanBPM interactors, the physiological role of RanBPM in cellular functions, and potential applications in disease therapeutics. | Scaffolding protein RanBPM and its interactions in diverse signaling pathways in health and disease.
Das S, Haq S, Ramakrishna S. | 09/29/2018 |
| Ran binding protein 9(RanBPM) is a scaffolding protein with a modulatory function that regulates the activities of IFN-stimulated response elements. IFN-lambda1 affects the cellular distribution of RanBPM and stimulates the interaction between RanBPM and interferon, lambda receptor 1(IFN-lambdaR1). Therefore, RanBPM plays a novel role in the IFN-lambda-regulated signaling pathway. | Ran binding protein 9 (RanBPM) binds IFN-λR1 in the IFN-λ signaling pathway.
Zhang J, Cong X, Zhaoqiao J, Yang X, Li M, Chen H, Mi R, Jin G, Liu F, Huang BR. | 05/12/2018 |
| Our work shows that RanBPM, together with the CTLH complex, associates with HDAC6 and restricts cell migration through inhibition of HDAC6 activity. This study uncovers a novel function for the CTLH complex and suggests that it could have a tumour suppressive role in restricting HDAC6 oncogenic properties. | Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex.
Salemi LM, Maitland MER, Yefet ER, Schild-Poulter C., Free PMC Article | 03/31/2018 |
| High RANBPM expression is associated with cancer. | Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth.
Lim KH, Suresh B, Park JH, Kim YS, Ramakrishna S, Baek KH., Free PMC Article | 01/6/2018 |
| RanBP9/TSSC3 complex cooperatively suppress metastasis via downregulation of Src-dependent Akt pathway to expedite mitochondrial-associated anoikis. | RanBP9/TSSC3 complex cooperates to suppress anoikis resistance and metastasis via inhibiting Src-mediated Akt signaling in osteosarcoma.
Dai H, Lv YF, Yan GN, Meng G, Zhang X, Guo QN., Free PMC Article | 10/14/2017 |
| Results show that increased expression of RanBPM associates with postponed disease progression and better prognosis suggesting that RanBPM plays an inhibitory role in regulating proliferation and invasion of lung cancer cells. | Reduced Expression of RanBPM Is Associated with Poorer Survival from Lung Cancer and Increased Proliferation and Invasion of Lung Cancer Cells In Vitro.
Zhao Z, Cheng S, Zabkiewicz C, Chen J, Zhang L, Ye L, Jiang WG. | 09/9/2017 |
| The 20-mer peptide (residues 228-247) of human DDX-4, an ATP-dependent RNA helicase known to regulate germ cell development, binds to a unique shallow binding surface on RanBPM formed by highly conserved loops on the surface of the beta-sheet with two aspartates on one end, a positive patch on the opposite end, and a tryptophan lining at the bottom of the surface. | Structural Basis for the Interaction between the IUS-SPRY Domain of RanBPM and DDX-4 in Germ Cell Development.
Hong SK, Kim KH, Song EJ, Kim EE. | 06/24/2017 |
| RanBPM acts as a negative regulator of BLT2 and IL8, thus attenuating the invasiveness of aggressive breast cancer cells | RanBPM inhibits BLT2-mediated IL-8 production and invasiveness in aggressive breast cancer cells.
Wei JD, Jang JH, Kim JH. | 06/10/2017 |
| RanBP9 absence hampers the molecular mechanisms leading to efficient repair of damaged DNA, resulting in enhanced sensitivity to genotoxic stress. | Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells.
Palmieri D, Scarpa M, Tessari A, Uka R, Amari F, Lee C, Richmond T, Foray C, Sheetz T, Braddom A, Burd CE, Parvin JD, Ludwig T, Croce CM, Coppola V., Free PMC Article | 02/18/2017 |
| Loss of RanBPM expression may play an important role in gastric cancer tumor development and metastasis. Reduced RanBPM expression is also associated with chemoresistance of gastric cancer cells. | Reduced RanBPM Expression Is Associated with Distant Metastasis in Gastric Cancer and Chemoresistance.
Shao S, Sun PH, Satherley LK, Gao X, Ji KE, Feng YI, Jia Y, Ji J, Jiang WG, Ye L. | 11/12/2016 |
| RanBP9 is positively expressed in bone tumor tissues and cell strains. | Expression of cartilage antitumor component RanBP9 in osteosarcoma.
Zhu LL, Wang CH, Yang HP, Shu WH. | 07/16/2016 |
| RanBPM was found to enhance Zta-dependent transcriptional activity via the inhibition of Zta sumoylation. | RanBPM regulates Zta-mediated transcriptional activity in Epstein-Barr virus.
Yang YC, Feng TH, Chen TY, Huang HH, Hung CC, Liu ST, Chang LK. | 12/19/2015 |
| association analyses between RANBP9 variants and the risk of schizophrenia were conducted, however no significant association was identified. | Investigating the potential genetic association between RANBP9 polymorphisms and the risk of schizophrenia.
Bae JS, Kim JY, Park BL, Cheong HS, Kim JH, Namgoong S, Kim JO, Park CS, Kim BJ, Lee CS, Lee M, Choi WH, Shin TM, Hwang J, Shin HD, Woo SI. | 09/26/2015 |
| RanBP9 relocates APP intracellular domain to Tip60-enriched nuclear speckles and prevented the formation of nuclear spots formation; results place RanBP9 as an important player in the multiple steps of AbetaPP signaling | RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60.
Domingues SC, Konietzko U, Henriques AG, Rebelo S, Fardilha M, Nishitani H, Nitsch RM, da Cruz E Silva EF, da Cruz E Silva OA. | 07/26/2015 |
| these analyses reveal that RanBPM subcellular localization results from the combined effects of several elements that either confer direct transport through the nucleocytoplasmic transport machinery | Characterization of RanBPM molecular determinants that control its subcellular localization.
Salemi LM, Loureiro SO, Schild-Poulter C., Free PMC Article | 04/4/2015 |
| RanBP9 transgene overexpression causes early synaptic deficits, impaired learning and accelerates amyloid plaque accumulation. | RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain.
Palavicini JP, Wang H, Minond D, Bianchi E, Xu S, Lakshmana MK. | 11/8/2014 |
| COPS5 is a novel RanBP9-binding protein that increases APP processing and Abeta generation by stabilizing RanBP9 protein levels | COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.
Wang H, Dey D, Carrera I, Minond D, Bianchi E, Xu S, Lakshmana MK., Free PMC Article | 12/21/2013 |
| RanBPM acts as a negative regulator of BLT2 signaling to attenuate BLT2-mediated cell motility | RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility.
Wei JD, Kim JY, Kim AK, Jang SK, Kim JH., Free PMC Article | 12/21/2013 |
| RanBPM influences TRAF6 ubiquitination and the TRAF6-triggered NF-kappaB signaling pathway through RanBPM's interaction with TRAF6. These data suggest that RanBPM participates in gene transcription by binding to TRAF6. | The Ran-binding protein RanBPM can depress the NF-κB pathway by interacting with TRAF6.
Wang L, Fu C, Cui Y, Xie Y, Yuan Y, Wang X, Chen H, Huang BR. | 06/16/2012 |
| Data indicate that RanBP9 simultaneously inhibits cell-adhesive processes and enhances Abeta generation by accelerating APP, LRP, and beta1-integrin endocytosis. | Pivotal role of RanBP9 in integrin-dependent focal adhesion signaling and assembly.
Woo JA, Roh SE, Lakshmana MK, Kang DE., Free PMC Article | 06/2/2012 |
| results indicate that RanBPM, potentially through interaction with citron kinase, plays a role in the progression of neocortical precursors through M-phase at the ventricular surface. | RanBPM regulates the progression of neuronal precursors through M-phase at the surface of the neocortical ventricular zone.
Chang Y, Paramasivam M, Girgenti MJ, Walikonis RS, Bianchi E, LoTurco JJ., Free PMC Article | 12/16/2011 |
| RanBPM co-localizes with p42IP4 and, together with p42(IP4), the SPRY domain of RanBPM could act as a modulator of synaptic plasticity. | RanBPM, a novel interaction partner of the brain-specific protein p42IP4/centaurin alpha-1.
Haase A, Nordmann C, Sedehizade F, Borrmann C, Reiser G. | 08/16/2010 |
| data support the idea that RanBP9 and RanBP10 may function as signaling integrators and dictate the efficient regulation of D(1) receptor signaling by PKCdelta and PKCgamma | Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.
Rex EB, Rankin ML, Yang Y, Lu Q, Gerfen CR, Jose PA, Sibley DR., Free PMC Article | 08/2/2010 |