Kcnk9 potassium two pore domain channel subfamily K member 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnk9provided by RGD
Official Full Name: potassium two pore domain channel subfamily K member 9provided by RGD
Primary source: RGD:621451
See related: Ensembl:ENSRNOG00000009265 AllianceGenome:RGD:621451
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Task3; Task-3
Summary: Predicted to enable potassium ion leak channel activity and voltage-gated potassium channel activity. Involved in potassium ion transport. Located in plasma membrane and synaptic vesicle. Human ortholog(s) of this gene implicated in Birk-Barel syndrome. Orthologous to human KCNK9 (potassium two pore domain channel subfamily K member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 538.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (106316783..106362452, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (104429186..104473924, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (113894918..113938397, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study analyzed TASK-1 and TASK-3 expression in ipsilateral and contralateral dorsal root ganglia and dorsal and ventral spinal cord of naive and formalin-treated or nerve injured rats. Pharmacological and molecular data suggest that TASK-1 and TASK-3 reduce the nociceptive transmission in acute/chronic inflammatory and neuropathic pain suggesting antinociceptive role of these channels in inflammatory and neuropathic pain.
Title: Spinal TASK-1 and TASK-3 modulate inflammatory and neuropathic pain.
results demonstrate that neurotensin (NT) transiently increased the neuronal excitability of dentate gyrus granule cells (GCs) by inhibiting TASK-3 channels; NT-mediated increases in neuronal excitability facilitate long-term potentiation at the perforant path-GC synapses
Title: Neurotensinergic Excitation of Dentate Gyrus Granule Cells via Gαq-Coupled Inhibition of TASK-3 Channels.
Hydroxy-alpha sanshool evokes colonic motility via blockage of the neural KCNK9 channel in the colonic myenteric plexus.
Title: Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9.
the entire rat brain was immunocytochemically analyzed for expression of TASK-3 protein.
Title: Immunocytochemical localization of TASK-3 protein (K2P9.1) in the rat brain.
In the dorsal horn of the developing rat, TWIK-related acid-sensitive K(+) channels TASK-1 (KCNK3) and TASK-3 (KCNK9) were down-regulated during postnatal development
Title: Transcriptional expression of voltage-gated Na⁺ and voltage-independent K⁺ channels in the developing rat superficial dorsal horn.
Expression of the TASK-3 protein in motor systems of the rat central nervous system was examined.
Title: Immunocytochemical localization of TASK-3 channels in rat motor neurons.
Results suggest that expression of TASK-2 and TASK-3 (but not TASK-1) undergoes age-related changes in dorsal root ganglion (DRG) neurons; TASK-2 and TASK-3 are likely to contribute to resting membrane potential in DRG neurons in neonates and adults.
Title: Age-related changes in two-pore domain acid-sensitive K⁺ channel expression in rat dorsal root ganglion neurons.
TASK-3 immunoreactivity was observed in neurons of the rat hippocampus
Title: Changes in TWIK-related acid sensitive K+-1 and -3 channel expressions from neurons to glia in the hippocampus of temporal lobe epilepsy patients and experimental animal model.
Immunofluorescence double-labeling experiments with appropriate marker enzymes confirmed the expression of TASK-3 in cholinergic, serotoninergic, and noradrenergic neurons.
Title: Immunocytochemical localization of TASK-3 (K(2P)9.1) channels in monoaminergic and cholinergic neurons.
cAMP-dependent protein kinase is responsible for the phosphorylation of the terminal serine in both K(2P)3.1 and K(2P)9.1
Title: Protein kinase A is central for forward transport of two-pore domain potassium channels K2P3.1 and K2P9.1.

Submit: New GeneRIF Correction See all GeneRIFs (28)

General gene information

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Markers

Kcnk9 (e-PCR), detects polymorphism
- UniSTS:547599

Kcnk9 (e-PCR), detects polymorphism
- UniSTS:547600

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in stabilization of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: potassium channel subfamily K member 9

Names: TWIK-related acid-sensitive K(+) channel 3; acid-sensitive potassium channel protein TASK-3; potassium channel, subfamily K, member 9 (Task-3); potassium channel, two pore domain subfamily K, member 9; two pore K(+) channel KT3.2; two pore potassium channel KT3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053405.2 → NP_445857.2 potassium channel subfamily K member 9 precursor

See identical proteins and their annotated locations for NP_445857.2

Status: PROVISIONAL

Source sequence(s)

AF391084

UniProtKB/Swiss-Prot

Q923V6, Q9ES08, Q9JLD4

UniProtKB/TrEMBL

A6HRU7

Related

ENSRNOP00000012408.1, ENSRNOT00000012408.4

Conserved Domains (1) summary

pfam07885
Location:77 → 132

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

106316783..106362452 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595136.3 → XP_017450625.1 potassium channel subfamily K member 9 isoform X1

UniProtKB/Swiss-Prot

Q923V6, Q9ES08, Q9JLD4

UniProtKB/TrEMBL

A6HRU7