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    Ica1 islet cell autoantigen 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81024, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ica1provided by RGD
    Official Full Name
    islet cell autoantigen 1provided by RGD
    Primary source
    RGD:621465
    See related
    Ensembl:ENSRNOG00000008628 AllianceGenome:RGD:621465
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ica69
    Summary
    Enables protein domain specific binding activity. Involved in regulation of protein-containing complex assembly. Located in Golgi apparatus; dendrite; and perinuclear region of cytoplasm. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ICA1 (islet cell autoantigen 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 276.6), Brain (RPKM 138.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (37622759..37771055, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (36656475..36804705, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (34635509..34780187, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486727 Neighboring gene glucocorticoid induced 1 Neighboring gene replication protein A3 Neighboring gene uncharacterized LOC102550643 Neighboring gene neurexophilin 1 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Metabolic and genomic dissection of diabetes in the Cohen rat. Yagil C, et al. Physiol Genomics, 2007 Apr 24. PMID 17213368
    2. Reduced thymic expression of islet antigen contributes to loss of self-tolerance. Mathews CE, et al. Ann N Y Acad Sci, 2003 Nov. PMID 14679103
    3. HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus. Roep BO, et al. Eur J Immunol, 1996 Jun. PMID 8647206
    4. PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites. Xu J, et al. J Neurosci, 2014 Nov 12. PMID 25392508, Free PMC Article
    5. Sex-specific genetic dissection of diabetes in a rodent model identifies Ica1 and Ndufa4 as major candidate genes. Barkalifa R, et al. Physiol Genomics, 2010 Aug. PMID 20530722

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study showed that PICK1, being negatively regulated by ICA69, could facilitate synapse maturation.
      Title: PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites.
    2. Sex-specific genetic dissection of diabetes in a rodent model identifies Ica1 and Ndufa4 as major candidate genes.
      Title: Sex-specific genetic dissection of diabetes in a rodent model identifies Ica1 and Ndufa4 as major candidate genes.
    3. Islet cell autoantigen 69 kDa (ICA69) regulates AMPA receptor trafficking by preventing formation of homomeric protein interacting with C kinase 1 (PICK1) Bin/amphiphysin/Rvs (BAR) domain complexes.
      Title: PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors.
    4. ICA69 is an arfaptin-related protein that is likely to play a role in membrane trafficking at the Golgi complex and immature secretory granules in neurosecretory cells
      Title: Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells.
    5. Ica1, on chromosome 4, is a high priority candidate gene for the development of diet-induced diabetes in the Cohen rat.
      Title: Metabolic and genomic dissection of diabetes in the Cohen rat.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables membrane curvature sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane curvature sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    islet cell autoantigen 1
    Names
    69 kDa islet cell autoantigen
    ICAp69
    islet cell autoantigen 1, 69 kDa
    islet cell autoantigen p69
    p69

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030844.2 → NP_110471.2  islet cell autoantigen 1

      See identical proteins and their annotated locations for NP_110471.2

      Status: PROVISIONAL

      Source sequence(s)
      BC078812
      UniProtKB/Swiss-Prot
      Q63054, Q6P3W0
      UniProtKB/TrEMBL
      A0A0G2K9Z2, A6IDX8, Q6AZ05
      Conserved Domains (2) summary
      cd07661
      Location:52 → 255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260 → 480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      37622759..37771055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236095.5 → XP_006236157.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006236157.1

      UniProtKB/Swiss-Prot
      Q63054, Q6P3W0
      UniProtKB/TrEMBL
      A0A0G2K9Z2, A6IDX8, Q6AZ05
      Related
      ENSRNOP00000095862.1
      Conserved Domains (2) summary
      cd07661
      Location:52 → 255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260 → 480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    2. XM_039108416.2 → XP_038964344.1  islet cell autoantigen 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A739, A6IDX7, F7FFT7
      Related
      ENSRNOP00000086969.1
      Conserved Domains (2) summary
      cd07661
      Location:52 → 255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261 → 459
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    3. XM_063286740.1 → XP_063142810.1  islet cell autoantigen 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A739, A6IDX7

    4. XM_063286738.1 → XP_063142808.1  islet cell autoantigen 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9Z2, A6IDX8, Q6AZ05

    5. XM_063286742.1 → XP_063142812.1  islet cell autoantigen 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A739, A6IDX7

    6. XM_006236094.5 → XP_006236156.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006236156.1

      UniProtKB/Swiss-Prot
      Q63054, Q6P3W0
      UniProtKB/TrEMBL
      A0A0G2K9Z2, A6IDX8, Q6AZ05
      Conserved Domains (2) summary
      cd07661
      Location:52 → 255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260 → 480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    7. XM_063286741.1 → XP_063142811.1  islet cell autoantigen 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A739, A6IDX7

    8. XM_063286739.1 → XP_063142809.1  islet cell autoantigen 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A739, A6IDX7

    9. XM_006236092.5 → XP_006236154.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006236154.1

      UniProtKB/Swiss-Prot
      Q63054, Q6P3W0
      UniProtKB/TrEMBL
      A0A0G2K9Z2, A6IDX8, Q6AZ05
      Conserved Domains (2) summary
      cd07661
      Location:52 → 255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260 → 480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    10. XM_006236093.5 → XP_006236155.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006236155.1

      UniProtKB/Swiss-Prot
      Q63054, Q6P3W0
      UniProtKB/TrEMBL
      A0A0G2K9Z2, A6IDX8, Q6AZ05
      Related
      ENSRNOP00000075191.1
      Conserved Domains (2) summary
      cd07661
      Location:52 → 255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260 → 480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    11. XM_063286743.1 → XP_063142813.1  islet cell autoantigen 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A739, A6IDX7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63054.2 GenPept UniProtKB/Swiss-Prot:Q63054

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