ghrl ghrelin/obestatin prepropeptide [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ghrlprovided by ZNC
Official Full Name: ghrelin/obestatin prepropeptideprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070622-2
See related: Ensembl:ENSDARG00000054239 AllianceGenome:ZFIN:ZDB-GENE-070622-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ghr; ghre
Summary: Predicted to enable growth hormone-releasing hormone activity. Acts upstream of or within several processes, including chordate embryonic development; regulation of response to food; and response to food. Predicted to be located in extracellular region. Is expressed in several structures, including diencephalon; digestive system; endocrine system; heart; and immune system. Human ortholog(s) of this gene implicated in diabetic neuropathy; esophagus adenocarcinoma; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (40437481..40439615)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (40440482..40441978)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ghrelin regulates hyperactivity-like behaviors via growth hormone signaling pathway in zebrafish (Danio rerio).
Title: Ghrelin regulates hyperactivity-like behaviors via growth hormone signaling pathway in zebrafish (Danio rerio).
Pax4-Ghrelin mediates the conversion of pancreatic epsilon-cells to beta-cells after extreme beta-cell loss in zebrafish.
Title: Pax4-Ghrelin mediates the conversion of pancreatic ε-cells to β-cells after extreme β-cell loss in zebrafish.
although ghrelin is expressed in zebrafish pancreatic endocrine cells, a different site than in mammals, it is responsive to metabolic state in a similar manner as mammalian ghrelin
Title: Zebrafish ghrelin is expressed in pancreatic endocrine cells and regulated by metabolic state.
Ghrelin inhibits basal and induced oocyte maturation in zebrafish.
Title: Ghrelinergic system in fish ovaries and ghrelin inhibition of germinal vesicle breakdown in zebrafish oocytes.
These findings suggest that GHRL regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor in the central nervous system and partly involved in carbohydrate-glycogen metabolism.
Title: Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain.
Fish paralogues of the human ghrelin and motilin receptor genes were identified, including those from the zebrafish.[ghrelin receptor; motilin receptor]
Title: Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin.
Zebrafish is a unique model for functional studies of endogenous ghrelin, especially during embryonic development.
Title: The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development.
increase in the expression of preproghrelin mRNA during fasting, and its decrease following refeeding suggests an orexigenic role for ghrelin in zebrafish.
Title: Fasting induces preproghrelin mRNA expression in the brain and gut of zebrafish, Danio rerio.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth hormone-releasing hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of response to food	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to food	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ghrelin/obestatin prepropeptide

Names: ghrelin; ghrelin/obestatin preprohormone; preproghrelin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083872.1 → NP_001077341.1 ghrelin/obestatin prepropeptide precursor

See identical proteins and their annotated locations for NP_001077341.1

Status: PROVISIONAL

Source sequence(s)

AM055940

UniProtKB/TrEMBL

Q3ZV42

Related

ENSDARP00000120887.1, ENSDART00000136487.2

Conserved Domains (1) summary

pfam04643
Location:68 → 103

Motilin_assoc; Motilin/ghrelin-associated peptide

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

40437481..40439615

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476948.1 → XP_021332623.1 ghrelin/obestatin prepropeptide isoform X1

UniProtKB/TrEMBL

A0A8M9PZZ3, F1QKX9

Conserved Domains (1) summary

pfam04643
Location:68 → 103

Motilin_assoc; Motilin/ghrelin-associated peptide