birc6 baculoviral IAP repeat containing 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: birc6provided by ZNC
Official Full Name: baculoviral IAP repeat containing 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-091202-7
See related: Ensembl:ENSDARG00000074166 AllianceGenome:ZFIN:ZDB-GENE-091202-7
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity and ubiquitin conjugating enzyme activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and regulation of cytokinesis. Predicted to be active in nucleus. Orthologous to human BIRC6 (baculoviral IAP repeat containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 74

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (22587357..22741618)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (22567521..22721790)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Z8774 (e-PCR)
- UniSTS:45996

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cytokinesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 6

XP_009291311.1

EC 2.3.2.27

XP_009291312.1

EC 2.3.2.27

XP_009291313.1

EC 2.3.2.27

XP_009291314.1

EC 2.3.2.27

XP_009291315.1

EC 2.3.2.27

XP_009291316.1

EC 2.3.2.27

XP_009291317.1

EC 2.3.2.27

XP_017207299.1

EC 2.3.2.27

XP_021328806.1

EC 2.3.2.27

XP_021328807.1

EC 2.3.2.27

XP_021328808.1

EC 2.3.2.27

XP_021328809.1

EC 2.3.2.27

XP_021328810.1

EC 2.3.2.27

XP_021328811.1

EC 2.3.2.27

XP_021328812.1

EC 2.3.2.27

XP_021328813.1

EC 2.3.2.27

XP_021330033.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

22587357..22741618

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009293036.3 → XP_009291311.1 baculoviral IAP repeat-containing protein 6 isoform X1

UniProtKB/TrEMBL

A0A8M3AJT6, X1WF03

Related

ENSDARP00000128806.1, ENSDART00000157328.3

Conserved Domains (4) summary

COG3122
Location:2200 → 2311

YaiL; Uncharacterized conserved protein YaiL, DUF2058 family [Function unknown]

cd00195
Location:4667 → 4805

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam00653
Location:248 → 318

BIR; Inhibitor of Apoptosis domain

pfam12356
Location:3501 → 3664

DUF3643; Protein of unknown function (DUF3643)
XM_009293039.3 → XP_009291314.1 baculoviral IAP repeat-containing protein 6 isoform X4

UniProtKB/TrEMBL

A0A8M3AIY4

Conserved Domains (4) summary

COG3122
Location:2200 → 2311

YaiL; Uncharacterized conserved protein YaiL, DUF2058 family [Function unknown]

cd00195
Location:4666 → 4804

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam00653
Location:248 → 318

BIR; Inhibitor of Apoptosis domain

pfam12356
Location:3500 → 3663

DUF3643; Protein of unknown function (DUF3643)
XM_017351810.2 → XP_017207299.1 baculoviral IAP repeat-containing protein 6 isoform X8

UniProtKB/TrEMBL

A0A8M6YVT7
XM_009293041.3 → XP_009291316.1 baculoviral IAP repeat-containing protein 6 isoform X6

UniProtKB/TrEMBL

A0A8M3AJT9

Conserved Domains (4) summary

COG3122
Location:2200 → 2311

YaiL; Uncharacterized conserved protein YaiL, DUF2058 family [Function unknown]

cd00195
Location:4657 → 4795

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam00653
Location:248 → 318

BIR; Inhibitor of Apoptosis domain

pfam12356
Location:3491 → 3654

DUF3643; Protein of unknown function (DUF3643)
XM_009293037.3 → XP_009291312.1 baculoviral IAP repeat-containing protein 6 isoform X2

UniProtKB/TrEMBL

A0A8M3AU88

Conserved Domains (3) summary

cd00195
Location:4666 → 4804

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam00653
Location:248 → 318

BIR; Inhibitor of Apoptosis domain

pfam12356
Location:3500 → 3663

DUF3643; Protein of unknown function (DUF3643)
XM_009293038.3 → XP_009291313.1 baculoviral IAP repeat-containing protein 6 isoform X3

UniProtKB/TrEMBL

A0A8M3ARC4

Conserved Domains (4) summary

COG3122
Location:2199 → 2310

YaiL; Uncharacterized conserved protein YaiL, DUF2058 family [Function unknown]

cd00195
Location:4666 → 4804

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam00653
Location:248 → 318

BIR; Inhibitor of Apoptosis domain

pfam12356
Location:3500 → 3663

DUF3643; Protein of unknown function (DUF3643)
XM_009293040.3 → XP_009291315.1 baculoviral IAP repeat-containing protein 6 isoform X5

UniProtKB/TrEMBL

A0A8M3B2D6

Conserved Domains (4) summary

COG3122
Location:2196 → 2307

YaiL; Uncharacterized conserved protein YaiL, DUF2058 family [Function unknown]

cd00195
Location:4663 → 4801

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam00653
Location:248 → 318

BIR; Inhibitor of Apoptosis domain

pfam12356
Location:3497 → 3660

DUF3643; Protein of unknown function (DUF3643)
XM_009293042.3 → XP_009291317.1 baculoviral IAP repeat-containing protein 6 isoform X7

UniProtKB/TrEMBL

A0A8M3AU93

Conserved Domains (4) summary

COG3122
Location:2196 → 2307

YaiL; Uncharacterized conserved protein YaiL, DUF2058 family [Function unknown]

cd00195
Location:4653 → 4791

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam00653
Location:248 → 318

BIR; Inhibitor of Apoptosis domain

pfam12356
Location:3487 → 3650

DUF3643; Protein of unknown function (DUF3643)

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394987.1 Reference GRCz11 ALT_DRER_TU_1

Range

956..124803

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021473131.1 → XP_021328806.1 baculoviral IAP repeat-containing protein 6 isoform X9

UniProtKB/TrEMBL

A0A8M9Q2B0

Conserved Domains (3) summary

cd00022
Location:246 → 319

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4669 → 4807

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3501 → 3664

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_021473133.1 → XP_021328808.1 baculoviral IAP repeat-containing protein 6 isoform X11

UniProtKB/TrEMBL

A0A8M9PP35

Conserved Domains (3) summary

cd00022
Location:246 → 319

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4668 → 4806

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3500 → 3663

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_021473138.1 → XP_021328813.1 baculoviral IAP repeat-containing protein 6 isoform X16

UniProtKB/TrEMBL

A0A8M9PP49

Conserved Domains (3) summary

cd00022
Location:246 → 319

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4639 → 4777

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3471 → 3634

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_021473136.1 → XP_021328811.1 baculoviral IAP repeat-containing protein 6 isoform X14

UniProtKB/TrEMBL

A0A8M9Q2C3

Conserved Domains (3) summary

cd00022
Location:246 → 319

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4659 → 4797

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3491 → 3654

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_021473132.1 → XP_021328807.1 baculoviral IAP repeat-containing protein 6 isoform X10

UniProtKB/TrEMBL

A0A8M9PCN7

Conserved Domains (3) summary

cd00022
Location:246 → 319

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4668 → 4806

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3500 → 3663

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_021473134.1 → XP_021328809.1 baculoviral IAP repeat-containing protein 6 isoform X12

UniProtKB/TrEMBL

A0A8M9PVD8

Conserved Domains (3) summary

cd00022
Location:246 → 319

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4668 → 4806

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3500 → 3663

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_021473135.1 → XP_021328810.1 baculoviral IAP repeat-containing protein 6 isoform X13

UniProtKB/TrEMBL

A0A8M9Q6H7

Conserved Domains (3) summary

cd00022
Location:246 → 319

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4665 → 4803

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3497 → 3660

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_021473137.1 → XP_021328812.1 baculoviral IAP repeat-containing protein 6 isoform X15

UniProtKB/TrEMBL

A0A8M9PCP7

Conserved Domains (3) summary

cd00022
Location:246 → 319

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4655 → 4793

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3487 → 3650

BIRC6; Baculoviral IAP repeat-containing protein 6

Reference GRCz11 ALT_DRER_TU_2

Genomic

NW_018395328.1 Reference GRCz11 ALT_DRER_TU_2

Range

304282..338418

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474358.1 → XP_021330033.1 baculoviral IAP repeat-containing protein 6 isoform X17

UniProtKB/TrEMBL

A0A8M9PSN1

Conserved Domains (1) summary

cd00022
Location:246 → 319

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...