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    Gabrg3 gamma-aminobutyric acid type A receptor subunit gamma 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79211, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gabrg3provided by RGD
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit gamma 3provided by RGD
    Primary source
    RGD:621735
    See related
    Ensembl:ENSRNOG00000014862 AllianceGenome:RGD:621735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GABA-A receptor activity and chloride channel activity. Involved in response to xenobiotic stimulus. Predicted to be located in postsynaptic membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in GABA-ergic synapse; dendrite membrane; and postsynapse. Predicted to be integral component of synaptic membrane. Orthologous to human GABRG3 (gamma-aminobutyric acid type A receptor subunit gamma3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 41.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (116763332..117386770, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (107627450..108247483, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (112158525..112812267, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3 alpha, pseudogene 3 Neighboring gene OCA2 melanosomal transmembrane protein Neighboring gene DNA polymerase epsilon 3, accessory subunit, pseudogene 1 Neighboring gene ribosomal protein L6, pseudogene 17 Neighboring gene inactive serine/threonine-protein kinase VRK3-like Neighboring gene uncharacterized LOC120099822 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha 5 Neighboring gene SAP domain containing ribonucleoprotein, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The gamma 3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands. Knoflach F, et al. FEBS Lett, 1991 Nov 18. PMID 1660002
    2. The third gamma subunit of the gamma-aminobutyric acid type A receptor family. Herb A, et al. Proc Natl Acad Sci U S A, 1992 Feb 15. PMID 1311098, Free PMC Article
    3. Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition. Sulpizio A, et al. Life Sci, 1978 Apr 24. PMID 27681
    4. Postsynaptic clustering of gamma-aminobutyric acid type A receptors by the gamma3 subunit in vivo. Baer K, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10536013, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA-A receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GABA-gated chloride ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to benzodiazepine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in inhibitory synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic transmission, GABAergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transmembrane transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit gamma-3
    Names
    GABA(A) receptor subunit gamma-3
    GABA-alpha receptor gamma-3 subunit
    gamma-aminobutyric acid (GABA) A receptor, gamma 3
    gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3
    gamma-aminobutyric acid A receptor, gamma 3
    gamma-aminobutyric acid type A receptor gamma 3 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024370.3 → NP_077346.3  gamma-aminobutyric acid receptor subunit gamma-3 precursor

      See identical proteins and their annotated locations for NP_077346.3

      Status: VALIDATED

      Source sequence(s)
      M81142, X63324
      UniProtKB/Swiss-Prot
      P28473
      UniProtKB/TrEMBL
      A0A0A0MXX6, A6KD36
      Related
      ENSRNOP00000076184.1, ENSRNOT00000093339.2
      Conserved Domains (3) summary
      TIGR00860
      Location:50 → 464
      LIC; Cation transporter family protein
      pfam02931
      Location:48 → 253
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:260 → 461
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      116763332..117386770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589765.3 → XP_017445254.1  gamma-aminobutyric acid receptor subunit gamma-3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28473.1 GenPept UniProtKB/Swiss-Prot:P28473

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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