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    APLP2 amyloid beta precursor like protein 2 [ Bos taurus (cattle) ]

    Gene ID: 785005, updated on 5-Mar-2024

    Summary

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    Official Symbol
    APLP2provided by VGNC
    Official Full Name
    amyloid beta precursor like protein 2provided by VGNC
    Primary source
    VGNC:VGNC:26020
    See related
    BGD:BT20246; Ensembl:ENSBTAG00000016168
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 29
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (36263071..36325813)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene PR/SET domain 10 Neighboring gene uncharacterized protein MISP3-like Neighboring gene zinc finger protein 740 pseudogene Neighboring gene translation machinery-associated protein 7-like Neighboring gene uncharacterized LOC132344197 Neighboring gene ST14 transmembrane serine protease matriptase Neighboring gene transfer RNA glutamic acid (anticodon UUC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    amyloid-like protein 2; amyloid beta precursor like protein 2
    Names
    amyloid beta (A4) precursor-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      36263071..36325813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002699235.6 → XP_002699281.1  amyloid beta precursor like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_002699281.1

      UniProtKB/TrEMBL
      A0A3Q1M9W8, F1N226
      Related
      ENSBTAP00000021524.6, ENSBTAT00000021524.7
      Conserved Domains (6) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:313 → 365
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:49 → 147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:713 → 763
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149 → 204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:369 → 551
      APP_E2; E2 domain of amyloid precursor protein

    2. XM_005226865.5 → XP_005226922.1  amyloid beta precursor like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_005226922.1

      UniProtKB/TrEMBL
      A0A3Q1M9W8
      Related
      ENSBTAP00000067367.2, ENSBTAT00000071927.2
      Conserved Domains (6) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:313 → 365
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:49 → 147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:701 → 751
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149 → 204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:369 → 551
      APP_E2; E2 domain of amyloid precursor protein

    3. XM_005226866.5 → XP_005226923.1  amyloid beta precursor like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_005226923.1

      UniProtKB/TrEMBL
      A0A3Q1M9W8
      Conserved Domains (5) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam02177
      Location:49 → 147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:657 → 707
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149 → 204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:313 → 495
      APP_E2; E2 domain of amyloid precursor protein

    4. XM_005226867.5 → XP_005226924.1  amyloid beta precursor like protein 2 isoform X4

      See identical proteins and their annotated locations for XP_005226924.1

      UniProtKB/TrEMBL
      A0A3Q1M9W8
      Related
      ENSBTAP00000064054.2, ENSBTAT00000075694.2
      Conserved Domains (5) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam02177
      Location:49 → 147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:645 → 695
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149 → 204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:313 → 495
      APP_E2; E2 domain of amyloid precursor protein
    Nucleotide Protein Strain
    Heading Accession and Version

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