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    IAPP islet amyloid polypeptide [ Felis catus (domestic cat) ]

    Gene ID: 751513, updated on 5-Mar-2024

    Summary

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    Official Symbol
    IAPP
    Official Full Name
    islet amyloid polypeptide
    Primary source
    VGNC:VGNC:84035
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: B4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (54166010..54262071)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B4 NC_018729.3 (56226268..56238393)

    Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family member 1C1 Neighboring gene solute carrier organic anion transporter family member 1B3 Neighboring gene prefoldin subunit 4-like Neighboring gene solute carrier organic anion transporter family member 1A2 Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of cat islet amyloid polypeptide and identification of amino acid residues of potential significance for islet amyloid formation. Betsholtz C, et al. Diabetes, 1990 Jan. PMID 2210054
    2. Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus. Henson MS, et al. Am J Vet Res, 2011 Aug. PMID 21801062
    3. Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Westermark P, et al. Proc Natl Acad Sci U S A, 1987 Jun. PMID 3035556, Free PMC Article
    4. Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. Nishi M, et al. Proc Natl Acad Sci U S A, 1989 Aug. PMID 2668946, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results of the present study added to those earlier findings in cats and revealed that nondiabetic moderately obese cats had significantly increased plasma islet amyloid polypeptide concentrations, compared with those of cats of ideal body weight.
      Title: Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    islet amyloid polypeptide
    Names
    amylin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001043338.1 → NP_001036803.1  islet amyloid polypeptide precursor

      See identical proteins and their annotated locations for NP_001036803.1

      Status: PROVISIONAL

      Source sequence(s)
      M25388
      UniProtKB/Swiss-Prot
      P12967
      Conserved Domains (1) summary
      pfam00214
      Location:31 → 73
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      54166010..54262071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045060767.1 → XP_044916702.1  islet amyloid polypeptide isoform X1

      UniProtKB/Swiss-Prot
      P12967
      Conserved Domains (1) summary
      pfam00214
      Location:31 → 73
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    2. XM_019833865.2 → XP_019689424.1  islet amyloid polypeptide isoform X1

      UniProtKB/Swiss-Prot
      P12967
      Conserved Domains (1) summary
      pfam00214
      Location:31 → 73
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12967.1 GenPept UniProtKB/Swiss-Prot:P12967

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