stra6 signaling receptor and transporter of retinol STRA6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stra6provided by ZNC
Official Full Name: signaling receptor and transporter of retinol STRA6provided by ZNC
Primary source: ZFIN:ZDB-GENE-060616-252
See related: Ensembl:ENSDARG00000051874 AllianceGenome:ZFIN:ZDB-GENE-060616-252
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7151282; wu:fc51h06; zgc:136689
Summary: Enables calmodulin binding activity and identical protein binding activity. Acts upstream of or within chordate embryonic development and retinol transport. Is integral component of plasma membrane. Is expressed in several structures, including hindbrain neural plate; immature eye; nervous system; pleuroperitoneal region; and trunk. Used to study syndromic microphthalmia 9. Human ortholog(s) of this gene implicated in syndromic microphthalmia 9. Orthologous to human STRA6 (signaling receptor and transporter of retinol STRA6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (22571678..22634675)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (22474748..22537127)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Physiologically Relevant Free Ca(2+) Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6.
Title: Physiologically Relevant Free Ca(2+) Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6.
We found that the major protein repeatedly identified as STRA6-associated protein is calmodulin, consistent with the cryogenic electron microscopy (cryo-EM) study of zebrafish STRA6 associated with calmodulin
Title: Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport.
this study presents the structure of zebrafish STRA6 determined to 3.9-angstrom resolution by single-particle cryo-electron microscopy.
Title: Structure of the STRA6 receptor for retinol uptake.
STRA6 deficiency leads to accumulation of RBP-4 bound vitamin A and developmental abnormalities.
Title: RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables retinal binding	IEA Inferred from Electronic Annotation more info
enables retinol binding	IEA Inferred from Electronic Annotation more info
enables retinol transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin A import into cell	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor for retinol uptake stra6; stimulated by retinoic acid gene 6 protein homolog

Names: stimulated by retinoic acid 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045312.1 → NP_001038777.1 receptor for retinol uptake stra6

See identical proteins and their annotated locations for NP_001038777.1

Status: PROVISIONAL

Source sequence(s)

BC117633

UniProtKB/Swiss-Prot

F1RAX4

Related

ENSDARP00000067478.5, ENSDART00000067479.6

Conserved Domains (1) summary

pfam14752
Location:29 → 628

RBP_receptor; Retinol binding protein receptor

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

22571678..22634675

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021470528.1 → XP_021326203.1 stimulated by retinoic acid gene 6 protein homolog isoform X1

UniProtKB/Swiss-Prot

A4IGB6, F1RAX4, Q1ECX5

UniProtKB/TrEMBL

A0A8M9PGX1

Conserved Domains (1) summary

pfam14752
Location:29 → 628

RBP_receptor; Retinol binding protein receptor
XM_005170689.4 → XP_005170746.1 stimulated by retinoic acid gene 6 protein homolog isoform X1

UniProtKB/Swiss-Prot

A4IGB6, F1RAX4, Q1ECX5

UniProtKB/TrEMBL

A0A8M9PGX1

Related

ENSDARP00000126450.1, ENSDART00000152096.3

Conserved Domains (1) summary

pfam14752
Location:29 → 628

RBP_receptor; Retinol binding protein receptor