ttll3 tubulin tyrosine ligase-like family, member 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ttll3provided by ZNC
Official Full Name: tubulin tyrosine ligase-like family, member 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-060616-182
See related: Ensembl:ENSDARG00000053728 AllianceGenome:ZFIN:ZDB-GENE-060616-182
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:136840
Summary: Enables tubulin-glycine ligase activity. Involved in axoneme assembly and protein polyglycylation. Acts upstream of or within cilium movement. Located in cilium. Is expressed in lateral line; peripheral olfactory organ; and pronephros. Orthologous to several human genes including TTLL3 (tubulin tyrosine ligase like 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (40327944..40352215, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (40331510..40354679, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish cilia structure and motility.
Title: Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish cilia structure and motility.
TTLL3 proteins act as tubulin glycine ligases with chain-initiating activity.
Title: TTLL3 Is a tubulin glycine ligase that regulates the assembly of cilia.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acid-amino acid ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein-glycine ligase activity, initiating	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glycine ligase activity, initiating	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin-glycine ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axoneme assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium movement	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein polyglycylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulin monoglycylase TTLL3

Names: tubulin--tyrosine ligase-like protein 3

NP_001038770.1

EC 6.3.2.-

XP_009300837.1

EC 6.3.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045305.1 → NP_001038770.1 tubulin monoglycylase TTLL3

See identical proteins and their annotated locations for NP_001038770.1

Status: PROVISIONAL

Source sequence(s)

BC117656

UniProtKB/Swiss-Prot

Q1ECV4

Related

ENSDARP00000094767.3, ENSDART00000103992.4

Conserved Domains (1) summary

pfam03133
Location:273 → 554

TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

40327944..40352215 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009302562.3 → XP_009300837.1 tubulin monoglycylase TTLL3 isoform X1

UniProtKB/TrEMBL

A0A8M3BAI3

Conserved Domains (1) summary

cl17255
Location:1 → 205

ATP-grasp_4; ATP-grasp domain