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    Spata24 spermatogenesis associated 24 [ Mus musculus (house mouse) ]

    Gene ID: 71242, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Spata24provided by MGI
    Official Full Name
    spermatogenesis associated 24provided by MGI
    Primary source
    MGI:MGI:1918492
    See related
    Ensembl:ENSMUSG00000024352 AllianceGenome:MGI:1918492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TIPT; TIPT2; 2700012K08Rik; 4930583E11Rik; 5133400G04Rik
    Summary
    Enables DNA binding activity and identical protein binding activity. Predicted to act upstream of or within cell differentiation and spermatogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; endocrine gland; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human SPATA24 (spermatogenesis associated 24). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 149.9) and liver E14 (RPKM 6.1) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 B2; 18 19.2 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35789742..35795239, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35656689..35662186, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene marginal zone B and B1 cell-specific protein 1 Neighboring gene proline rich basic protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7578 Neighboring gene DnaJ heat shock protein family (Hsp40) member C18 Neighboring gene STARR-seq mESC enhancer starr_44246 Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1. Brancorsini S, et al. Cell Cycle, 2008 May 15. PMID 18418073
    2. TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation. Pitulescu ME, et al. BMC Biochem, 2009 Jun 10. PMID 19515240, Free PMC Article
    3. CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†. Sun J, et al. Biol Reprod, 2020 Aug 4. PMID 32588039, Free PMC Article
    4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1.
      Title: TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1.
    2. TIPT2 synergizes with geminin and TBP in the activation of TATA box-containing promoters.
      Title: TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 24
    Names
    TATA-binding protein-like factor-interacting protein
    TLF-interacting protein
    TRF2-interacting protein in testis
    testis protein T6441 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027733.5 → NP_082009.3  spermatogenesis-associated protein 24 isoform 1

      See identical proteins and their annotated locations for NP_082009.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AK016341, AW493519, BU961109
      Consensus CDS
      CCDS29147.1
      UniProtKB/TrEMBL
      A0A494B8X0
      Related
      ENSMUSP00000094324.3, ENSMUST00000096573.4
      Conserved Domains (1) summary
      pfam15175
      Location:25 → 128
      SPATA24; Spermatogenesis-associated protein 24

    2. NM_029485.2 → NP_083761.1  spermatogenesis-associated protein 24 isoform 2

      See identical proteins and their annotated locations for NP_083761.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains additional coding exons at the 3' end compared to transcript variant 1, and encodes a longer isoform (2) with a different C-terminus compared to isoform 1.
      Source sequence(s)
      BC060950, BM569619, BU961109
      Consensus CDS
      CCDS29146.1
      UniProtKB/Swiss-Prot
      Q5MMR1, Q6P926, Q9D4P6
      Related
      ENSMUSP00000025209.5, ENSMUST00000025209.12
      Conserved Domains (2) summary
      pfam15175
      Location:25 → 190
      SPATA24; Spermatogenesis-associated protein 24
      cl09839
      Location:120 → 171
      Csx1_III-U; CRISPR/Cas system-associated protein Csx1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      35789742..35795239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526248.5 → XP_006526311.1  spermatogenesis-associated protein 24 isoform X1

      UniProtKB/TrEMBL
      A0A494B928
      Related
      ENSMUSP00000157452.2, ENSMUST00000236539.2
      Conserved Domains (1) summary
      pfam15175
      Location:14 → 164
      SPATA24; Spermatogenesis-associated protein 24
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P926.1 GenPept UniProtKB/Swiss-Prot:Q6P926

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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