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    Eny2 ENY2, transcription and export complex 2 subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685258, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Eny2provided by RGD
    Official Full Name
    ENY2, transcription and export complex 2 subunitprovided by RGD
    Primary source
    RGD:1596439
    See related
    Ensembl:ENSRNOG00000004681 AllianceGenome:RGD:1596439
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity and nuclear receptor coactivator activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of nucleus. Orthologous to human ENY2 (ENY2 transcription and export complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 130.5), Kidney (RPKM 126.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eny2 in Genome Data Viewer
    Location:
    7q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (77465885..77489637)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (75581215..75605903)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (83348656..83358430)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene thyrotropin releasing hormone receptor Neighboring gene small nucleolar RNA SNORA17 Neighboring gene NudC domain containing 1 Neighboring gene PKHD1 like 1 Neighboring gene estrogen receptor binding site associated antigen 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells. Dames P, et al. Exp Diabetes Res, 2012. PMID 22649445, Free PMC Article
    2. The human TREX-2 complex is stably associated with the nuclear pore basket. Umlauf D, et al. J Cell Sci, 2013 Jun 15. PMID 23591820
    3. Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module. Li W, et al. Mol Cell Biol, 2016 Nov 15. PMID 27601583, Free PMC Article
    4. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Zhao Y, et al. Mol Cell, 2008 Jan 18. PMID 18206972
    5. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. there is a link between the nuclear protein Eny2 and insulin secretion
      Title: Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DUBm complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DUBm complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex 2 ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription and mRNA export factor ENY2
    Names
    enhancer of yellow 2 homolog
    enhancer of yellow 2 transcription factor homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130580.1 → NP_001124052.1  transcription and mRNA export factor ENY2

      See identical proteins and their annotated locations for NP_001124052.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HRB0, A6HRB2
      Conserved Domains (1) summary
      pfam10163
      Location:16 → 94
      EnY2; Transcription factor e(y)2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      77465885..77489637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264258.1 → XP_063120328.1  transcription and mRNA export factor ENY2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVD6

    2. XM_063264257.1 → XP_063120327.1  transcription and mRNA export factor ENY2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVD6

    3. XM_039079891.2 → XP_038935819.1  transcription and mRNA export factor ENY2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLL7, A6HRB2, A6HRB3
      Related
      ENSRNOP00000006402.5
      Conserved Domains (1) summary
      pfam10163
      Location:11 → 89
      EnY2; Transcription factor e(y)2

    4. XM_006241615.4 → XP_006241677.1  transcription and mRNA export factor ENY2 isoform X2

      See identical proteins and their annotated locations for XP_006241677.1

      UniProtKB/TrEMBL
      A0A8I5ZLL7, A6HRB2, A6HRB3
      Related
      ENSRNOP00000078855.1
      Conserved Domains (1) summary
      pfam10163
      Location:11 → 89
      EnY2; Transcription factor e(y)2
    Nucleotide Protein Strain
    Heading Accession and Version

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