Gpx7 glutathione peroxidase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpx7provided by MGI
Official Full Name: glutathione peroxidase 7provided by MGI
Primary source: MGI:MGI:1914555
See related: Ensembl:ENSMUSG00000028597 AllianceGenome:MGI:1914555
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPX6; 3110050F08Rik
Summary: Predicted to enable catalase activity. Predicted to be involved in response to oxidative stress. Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; integumental system; nose; and skeleton. Orthologous to human GPX7 (glutathione peroxidase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 39.9), limb E14.5 (RPKM 29.2) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 50.5 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (108257414..108263910, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (108400217..108406713, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway.
Title: GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway.
GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress.
Title: GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress.
NPGPx protects against fat accumulation in mice and human via modulating ROS
Title: Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
GPx7 is an unusual CysGPx catalyzing the peroxidatic cycle by a one Cys mechanism in which GSH and PDI are alternative substrates.
Title: Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.
NPGPx is essential for releasing excessive ER stress by enhancing GRP78 chaperone activity to maintain physiological homeostasis.
Title: Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gpx7 (e-PCR), detects polymorphism
- UniSTS:527370

AI327032 (e-PCR)
- UniSTS:164252

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalase activity	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione peroxidase 7

Names: GPx-7; GSHPx-7

NP_077160.1

EC 1.11.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024198.3 → NP_077160.1 glutathione peroxidase 7 precursor

See identical proteins and their annotated locations for NP_077160.1

Status: PROVISIONAL

Source sequence(s)

AK165221

Consensus CDS

CCDS18450.1

UniProtKB/Swiss-Prot

Q99LJ6

UniProtKB/TrEMBL

Q3TNK3

Related

ENSMUSP00000030332.7, ENSMUST00000030332.7

Conserved Domains (2) summary

TIGR02540
Location:23 → 175

gpx7; putative glutathione peroxidase Gpx7

pfam00578
Location:26 → 155

AhpC-TSA; AhpC/TSA family