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    C1galt1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65044, updated on 11-Apr-2024

    Summary

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    Official Symbol
    C1galt1provided by RGD
    Official Full Name
    core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1provided by RGD
    Primary source
    RGD:621105
    See related
    Ensembl:ENSRNOG00000007804 AllianceGenome:RGD:621105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be involved in O-glycan processing, core 1 and kidney development. Predicted to act upstream of or within angiogenesis; intestinal epithelial cell development; and protein O-linked glycosylation. Predicted to be integral component of membrane. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 303.8), Liver (RPKM 263.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (36894440..36932434)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (35930981..35966100)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (33890353..33943219)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene asparagine synthetase (glutamine-hydrolyzing) Neighboring gene uncharacterized LOC134486668 Neighboring gene tRNA (guanine-N(7)-)-methyltransferase-like Neighboring gene RNA polymerase I and III subunit D, pseudogene 1 Neighboring gene small nucleolar RNA SNORA3/SNORA45 family Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy. Li GS, et al. Kidney Int, 2007 Mar. PMID 17228361
    2. Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. Fu J, et al. J Clin Invest, 2011 Apr. PMID 21383503, Free PMC Article
    3. Cloning and expression of human core 1 beta1,3-galactosyltransferase. Ju T, et al. J Biol Chem, 2002 Jan 4. PMID 11677243
    4. Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans. Xia L, et al. J Cell Biol, 2004 Feb 2. PMID 14745002, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in O-glycan processing, core 1 IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intestinal epithelial cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intestinal epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
    Names
    core 1 O-glycan T-synthase
    core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
    core 1 beta1,3-galactosyltransferase 1
    core 1 beta3-Gal-T
    core 1 beta3-Gal-T1
    core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase (C1galt1)
    core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
    core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 13-galactosyltransferase (C1galt1)
    NP_001385639.1
    NP_075239.1
    XP_063142739.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398710.1 → NP_001385639.1  glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8L2Q5I0
      Related
      ENSRNOP00000010375.2, ENSRNOT00000010375.3
      Conserved Domains (1) summary
      cl21608
      Location:115 → 256
      Galactosyl_T; Galactosyltransferase

    2. NM_022950.3 → NP_075239.1  glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_075239.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q9JJ05
      UniProtKB/TrEMBL
      A6IDW5
      Related
      ENSRNOP00000079450.1, ENSRNOT00000112848.1
      Conserved Domains (1) summary
      cl21608
      Location:107 → 248
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      36894440..36932434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286669.1 → XP_063142739.1  glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNI5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJ05.1 GenPept UniProtKB/Swiss-Prot:Q9JJ05

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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