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    MGRN1 mahogunin ring finger 1 [ Bos taurus (cattle) ]

    Gene ID: 616130, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MGRN1provided by VGNC
    Official Full Name
    mahogunin ring finger 1provided by VGNC
    Primary source
    VGNC:VGNC:97285
    See related
    Ensembl:ENSBTAG00000018999
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 25
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (3755152..3791830)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene UBA like domain containing 1 Neighboring gene small nucleolar RNA SNORA1 Neighboring gene nudix hydrolase 16 like 1 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene dynein axonemal assembly factor 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC139947

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosome to lysosome transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MGRN1
    NP_001070410.2
    XP_005224604.1
    XP_005224605.1
    XP_005224606.1
    XP_005224607.1
    XP_005224610.1
    XP_024840806.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076942.2 → NP_001070410.2  E3 ubiquitin-protein ligase MGRN1

      See identical proteins and their annotated locations for NP_001070410.2

      Status: VALIDATED

      Source sequence(s)
      BC123484, DV815046, DV921089, EE365497
      UniProtKB/TrEMBL
      A0A3Q1MTG2, A0A8J8XU45, E1BE47, M5FJZ8
      Related
      ENSBTAP00000025290.5, ENSBTAT00000025290.7
      Conserved Domains (2) summary
      cd16789
      Location:277 → 317
      mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
      cl27165
      Location:232 → 331
      PHA02929; N1R/p28-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      3755152..3791830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005224547.5 → XP_005224604.1  E3 ubiquitin-protein ligase MGRN1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MTG2, A0A3Q1MY63
      Related
      ENSBTAP00000060906.1, ENSBTAT00000081180.2
      Conserved Domains (2) summary
      TIGR00599
      Location:273 → 532
      rad18; DNA repair protein rad18
      pfam13920
      Location:274 → 319
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. XM_005224548.5 → XP_005224605.1  E3 ubiquitin-protein ligase MGRN1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MTG2, J9JH89
      Related
      ENSBTAP00000055898.2, ENSBTAT00000066205.3
      Conserved Domains (2) summary
      TIGR00599
      Location:273 → 510
      rad18; DNA repair protein rad18
      pfam13920
      Location:274 → 319
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    3. XM_005224550.5 → XP_005224607.1  E3 ubiquitin-protein ligase MGRN1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MTG2
      Related
      ENSBTAP00000067458.2, ENSBTAT00000075708.2
      Conserved Domains (2) summary
      cd16789
      Location:277 → 317
      mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
      cl28410
      Location:273 → 500
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    4. XM_005224549.5 → XP_005224606.1  E3 ubiquitin-protein ligase MGRN1 isoform X3

      See identical proteins and their annotated locations for XP_005224606.1

      UniProtKB/TrEMBL
      A0A3Q1MB22, A0A3Q1MTG2
      Conserved Domains (2) summary
      TIGR00599
      Location:273 → 532
      rad18; DNA repair protein rad18
      pfam13920
      Location:274 → 319
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    5. XM_024985038.2 → XP_024840806.1  E3 ubiquitin-protein ligase MGRN1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MTG2
      Related
      ENSBTAP00000075914.1, ENSBTAT00000123105.1
      Conserved Domains (2) summary
      cd16789
      Location:277 → 317
      mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
      cl27165
      Location:232 → 331
      PHA02929; N1R/p28-like protein; Provisional

    6. XM_005224553.5 → XP_005224610.1  E3 ubiquitin-protein ligase MGRN1 isoform X6

      See identical proteins and their annotated locations for XP_005224610.1

      UniProtKB/TrEMBL
      A0A3Q1MTG2
      Conserved Domains (2) summary
      cd16789
      Location:277 → 317
      mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
      cl28410
      Location:273 → 500
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version

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