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    PER3 period circadian regulator 3 [ Bos taurus (cattle) ]

    Gene ID: 614154, updated on 5-Mar-2024

    Summary

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    Gene symbol
    PER3
    Gene description
    period circadian regulator 3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Summary
    This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. [provided by RefSeq, Feb 2014]
    Orthologs
    human mouse all
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    Genomic context

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    See PER3 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (45533849..45603004, complement)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 9 Neighboring gene urotensin 2 Neighboring gene calmodulin binding transcription activator 1 Neighboring gene vesicle associated membrane protein 3 Neighboring gene uncharacterized LOC112441841

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription corepressor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in circadian regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in entrainment of circadian clock by photoperiod IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    period circadian protein homolog 3; LOW QUALITY PROTEIN: period circadian protein homolog 3
    Names
    period circadian clock 3
    period homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      45533849..45603004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059875624.1 → XP_059731607.1  LOW QUALITY PROTEIN: period circadian protein homolog 3

    Nucleotide Protein Strain
    Heading Accession and Version

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