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    P4HA3 prolyl 4-hydroxylase subunit alpha 3 [ Canis lupus familiaris (dog) ]

    Gene ID: 609381, updated on 5-Mar-2024

    Summary

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    Official Symbol
    P4HA3provided by VGNC
    Official Full Name
    prolyl 4-hydroxylase subunit alpha 3provided by VGNC
    Primary source
    VGNC:VGNC:44224
    See related
    Ensembl:ENSCAFG00845006494
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See P4HA3 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (24192868..24235448)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (23755267..23797999)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (24105136..24147780)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (23990072..24032765)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (24187263..24230298)

    Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 3 Neighboring gene uncharacterized LOC111091533 Neighboring gene phosphoglucomutase 2 like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene protein phosphatase methylesterase 1 Neighboring gene cytochrome c oxidase subunit 6A1, mitochondrial-like Neighboring gene CDGSH iron-sulfur domain-containing protein 2-like Neighboring gene C2 domain containing 3 centriole elongation regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolyl 4-hydroxylase subunit alpha-3
    Names
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
    XP_005633573.2
    XP_005633574.2
    XP_022263400.2
    XP_038286057.1
    XP_038286058.1
    XP_038286059.1
    XP_038286060.1
    XP_038286061.1
    XP_038286062.1
    XP_038286063.1
    XP_038312311.1
    XP_038312312.1
    XP_038312313.1
    XP_038361419.1
    XP_038361420.1
    XP_038361421.1
    XP_038361422.1
    XP_038361423.1
    XP_038361424.1
    XP_038361425.1
    XP_038424591.1
    XP_038424592.1
    XP_038424593.1
    XP_038424594.1
    XP_038424595.1
    XP_038424596.1
    XP_038424597.1
    XP_038488763.1
    XP_038488764.1
    XP_038488765.1
    XP_038488766.1
    XP_038488767.1
    XP_038488768.1
    XP_851718.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051825.1 Reference ROS_Cfam_1.0

      Range
      24192868..24235448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038430135.1 → XP_038286063.1  prolyl 4-hydroxylase subunit alpha-3 isoform X6

      Conserved Domains (1) summary
      smart00702
      Location:249 → 420
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_038430129.1 → XP_038286057.1  prolyl 4-hydroxylase subunit alpha-3 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JKP4, A0A8C0JN69, A0A8I3MSQ5
      Related
      ENSCAFP00845009069.1, ENSCAFT00845011607.1
      Conserved Domains (2) summary
      smart00702
      Location:357 → 528
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038430131.1 → XP_038286059.1  prolyl 4-hydroxylase subunit alpha-3 isoform X4

      UniProtKB/TrEMBL
      A0A8C0JN69, A0A8I3N373
      Related
      ENSCAFP00845009102.1, ENSCAFT00845011660.1
      Conserved Domains (2) summary
      smart00702
      Location:357 → 505
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_038430130.1 → XP_038286058.1  prolyl 4-hydroxylase subunit alpha-3 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JN69, A0A8I3N1H2
      Related
      ENSCAFP00845009024.1, ENSCAFT00845011551.1
      Conserved Domains (2) summary
      smart00702
      Location:357 → 507
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_038430132.1 → XP_038286060.1  prolyl 4-hydroxylase subunit alpha-3 isoform X5

      UniProtKB/TrEMBL
      A0A8C0JN69, A0A8C0T2Z9
      Conserved Domains (2) summary
      smart00702
      Location:307 → 478
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    6. XM_038430133.1 → XP_038286061.1  prolyl 4-hydroxylase subunit alpha-3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0QTQ5
      Conserved Domains (2) summary
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
      cl21496
      Location:357 → 466
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    7. XM_038430134.1 → XP_038286062.1  prolyl 4-hydroxylase subunit alpha-3 isoform X6

      Conserved Domains (1) summary
      smart00702
      Location:249 → 420
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049281.1 Alternate UMICH_Zoey_3.1

      Range
      23990072..24032765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038505497.1 → XP_038361425.1  prolyl 4-hydroxylase subunit alpha-3 isoform X6

      Conserved Domains (1) summary
      smart00702
      Location:249 → 420
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_038505491.1 → XP_038361419.1  prolyl 4-hydroxylase subunit alpha-3 isoform X2

      Conserved Domains (2) summary
      smart00702
      Location:357 → 528
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038505493.1 → XP_038361421.1  prolyl 4-hydroxylase subunit alpha-3 isoform X4

      Conserved Domains (2) summary
      smart00702
      Location:357 → 505
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_038505492.1 → XP_038361420.1  prolyl 4-hydroxylase subunit alpha-3 isoform X3

      Conserved Domains (2) summary
      smart00702
      Location:357 → 507
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_038505494.1 → XP_038361422.1  prolyl 4-hydroxylase subunit alpha-3 isoform X5

      Conserved Domains (2) summary
      smart00702
      Location:307 → 478
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    6. XM_038505495.1 → XP_038361423.1  prolyl 4-hydroxylase subunit alpha-3 isoform X1

      Conserved Domains (2) summary
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
      cl21496
      Location:357 → 466
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    7. XM_038505496.1 → XP_038361424.1  prolyl 4-hydroxylase subunit alpha-3 isoform X6

      Conserved Domains (1) summary
      smart00702
      Location:249 → 420
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

      Range
      24187263..24230298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038632840.1 → XP_038488768.1  prolyl 4-hydroxylase subunit alpha-3 isoform X6

      Conserved Domains (1) summary
      smart00702
      Location:249 → 420
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_038632835.1 → XP_038488763.1  prolyl 4-hydroxylase subunit alpha-3 isoform X2

      Conserved Domains (2) summary
      smart00702
      Location:357 → 528
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038632837.1 → XP_038488765.1  prolyl 4-hydroxylase subunit alpha-3 isoform X4

      Conserved Domains (2) summary
      smart00702
      Location:357 → 505
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_038632836.1 → XP_038488764.1  prolyl 4-hydroxylase subunit alpha-3 isoform X3

      Conserved Domains (2) summary
      smart00702
      Location:357 → 507
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_038632838.1 → XP_038488766.1  prolyl 4-hydroxylase subunit alpha-3 isoform X5

      Conserved Domains (2) summary
      smart00702
      Location:307 → 478
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    6. XM_038632839.1 → XP_038488767.1  prolyl 4-hydroxylase subunit alpha-3 isoform X6

      Conserved Domains (1) summary
      smart00702
      Location:249 → 420
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

      Range
      24105136..24147780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038568669.1 → XP_038424597.1  prolyl 4-hydroxylase subunit alpha-3 isoform X6

      Conserved Domains (1) summary
      smart00702
      Location:249 → 420
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_038568663.1 → XP_038424591.1  prolyl 4-hydroxylase subunit alpha-3 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JKP4, A0A8C0JN69, A0A8I3MSQ5
      Conserved Domains (2) summary
      smart00702
      Location:357 → 528
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038568665.1 → XP_038424593.1  prolyl 4-hydroxylase subunit alpha-3 isoform X4

      UniProtKB/TrEMBL
      A0A8C0JN69, A0A8I3N373
      Conserved Domains (2) summary
      smart00702
      Location:357 → 505
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_038568664.1 → XP_038424592.1  prolyl 4-hydroxylase subunit alpha-3 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JN69, A0A8I3N1H2
      Conserved Domains (2) summary
      smart00702
      Location:357 → 507
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_038568666.1 → XP_038424594.1  prolyl 4-hydroxylase subunit alpha-3 isoform X5

      UniProtKB/TrEMBL
      A0A8C0JN69, A0A8C0T2Z9
      Conserved Domains (2) summary
      smart00702
      Location:307 → 478
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    6. XM_038568667.1 → XP_038424595.1  prolyl 4-hydroxylase subunit alpha-3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0QTQ5
      Conserved Domains (2) summary
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
      cl21496
      Location:357 → 466
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    7. XM_038568668.1 → XP_038424596.1  prolyl 4-hydroxylase subunit alpha-3 isoform X6

      Conserved Domains (1) summary
      smart00702
      Location:249 → 420
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      23755267..23797999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038456385.1 → XP_038312313.1  prolyl 4-hydroxylase subunit alpha-3 isoform X6

      Conserved Domains (1) summary
      smart00702
      Location:249 → 420
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_846625.5 → XP_851718.2  prolyl 4-hydroxylase subunit alpha-3 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JN69, A0A8P0PAL4
      Conserved Domains (2) summary
      smart00702
      Location:357 → 528
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_005633516.3 → XP_005633573.2  prolyl 4-hydroxylase subunit alpha-3 isoform X4

      UniProtKB/TrEMBL
      A0A8C0JN69, A0A8P0TCZ1
      Conserved Domains (2) summary
      smart00702
      Location:357 → 505
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_022407692.2 → XP_022263400.2  prolyl 4-hydroxylase subunit alpha-3 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JN69, A0A8P0SB13
      Conserved Domains (2) summary
      smart00702
      Location:357 → 507
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_005633517.3 → XP_005633574.2  prolyl 4-hydroxylase subunit alpha-3 isoform X5

      UniProtKB/TrEMBL
      A0A8C0JN69
      Conserved Domains (2) summary
      smart00702
      Location:307 → 478
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    6. XM_038456383.1 → XP_038312311.1  prolyl 4-hydroxylase subunit alpha-3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0QTQ5
      Conserved Domains (2) summary
      pfam08336
      Location:58 → 111
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
      cl21496
      Location:357 → 466
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    7. XM_038456384.1 → XP_038312312.1  prolyl 4-hydroxylase subunit alpha-3 isoform X6

      Conserved Domains (1) summary
      smart00702
      Location:249 → 420
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    Nucleotide Protein
    Heading Accession and Version

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