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    USP50 ubiquitin specific peptidase 50 [ Canis lupus familiaris (dog) ]

    Gene ID: 608487, updated on 5-Mar-2024

    Summary

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    Official Symbol
    USP50provided by VGNC
    Official Full Name
    ubiquitin specific peptidase 50provided by VGNC
    Primary source
    VGNC:VGNC:55016
    See related
    Ensembl:ENSCAFG00845023997
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See USP50 in Genome Data Viewer
    Location:
    chromosome: 30
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (16553219..16597774, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (16335379..16379877, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (16699584..16744702, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (16475706..16520238, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (16593382..16638297, complement)

    Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene GA binding protein transcription factor subunit beta 1 Neighboring gene ubiquitin specific peptidase 8 Neighboring gene U6 spliceosomal RNA Neighboring gene transient receptor potential cation channel subfamily M member 7 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like Neighboring gene signal peptide peptidase like 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endosome organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K48-linked deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K63-linked deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extrinsic component of endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extrinsic component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inactive ubiquitin carboxyl-terminal hydrolase 50
    Names
    putative ubiquitin carboxyl-terminal hydrolase 50-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051834.1 Reference ROS_Cfam_1.0

      Range
      16553219..16597774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038442318.1 → XP_038298246.1  inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L4D0, A0A8C0TCY6, A0A8I3PLB2
      Related
      ENSCAFP00845033209.1, ENSCAFT00845042360.1
      Conserved Domains (1) summary
      cd02674
      Location:45 → 360
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    2. XM_038442317.1 → XP_038298245.1  inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X1

      Conserved Domains (1) summary
      pfam00443
      Location:44 → 311
      UCH; Ubiquitin carboxyl-terminal hydrolase

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049290.1 Alternate UMICH_Zoey_3.1

      Range
      16475706..16520238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038516765.1 → XP_038372693.1  inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X2

      Conserved Domains (1) summary
      cd02674
      Location:45 → 360
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    2. XM_038516764.1 → XP_038372692.1  inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X1

      Conserved Domains (1) summary
      pfam00443
      Location:44 → 311
      UCH; Ubiquitin carboxyl-terminal hydrolase

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

      Range
      16593382..16638297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038644699.1 → XP_038500627.1  inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X2

      Conserved Domains (1) summary
      cd02674
      Location:45 → 360
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    2. XM_038644698.1 → XP_038500626.1  inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X1

      Conserved Domains (1) summary
      pfam00443
      Location:44 → 311
      UCH; Ubiquitin carboxyl-terminal hydrolase

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

      Range
      16699584..16744702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038580405.1 → XP_038436333.1  inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L4D0, A0A8C0TCY6, A0A8I3PLB2
      Conserved Domains (1) summary
      cd02674
      Location:45 → 360
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    2. XM_038580406.1 → XP_038436334.1  inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X3

    3. XM_038580404.1 → XP_038436332.1  inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X1

      Conserved Domains (1) summary
      pfam00443
      Location:44 → 311
      UCH; Ubiquitin carboxyl-terminal hydrolase

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      16335379..16379877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_845820.5 → XP_850913.1  inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L4D0, A0A8C0TCY6, A0A8I3PLB2
      Conserved Domains (1) summary
      cd02674
      Location:45 → 360
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    2. XM_038461109.1 → XP_038317037.1  inactive ubiquitin carboxyl-terminal hydrolase 50 isoform X1

      Conserved Domains (1) summary
      pfam00443
      Location:44 → 311
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version

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