Cttn cortactin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cttnprovided by RGD
Official Full Name: cortactinprovided by RGD
Primary source: RGD:619839
See related: Ensembl:ENSRNOG00000050994 AllianceGenome:RGD:619839
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cttnb
Summary: Enables Arp2/3 complex binding activity and proline-rich region binding activity. Involved in several processes, including focal adhesion assembly; modification of postsynaptic actin cytoskeleton; and plasma membrane bounded cell projection organization. Located in cell junction and clathrin-coated pit. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Colocalizes with actin filament; focal adhesion; and growth cone. Orthologous to human CTTN (cortactin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 441.7), Kidney (RPKM 297.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q42

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (209029048..209064577, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (199599710..199635254, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (217602698..217638196, complement) , (215255385..215290882, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cortactin knockdown results in disruption of basal TBCs and alters turnover of Sertoli cell ESs in Rattus norvegicusdagger.
Title: Cortactin knockdown results in disruption of basal TBCs and alters turnover of Sertoli cell ESs in Rattus norvegicus†.
Distribution of cortactin in cerebellar Purkinje cell spines.
Title: Distribution of cortactin in cerebellar Purkinje cell spines.
Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development.
Title: Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development.
These results demonstrate that cortactin maintains GluA2/A3 levels by directing receptors away from lysosomes, and that disrupting GluA2-cortactin interactions to target GluA2/A3 to lysosomes is an essential component of LTD expression.
Title: Cortactin regulates endo-lysosomal sorting of AMPARs via direct interaction with GluA2 subunit.
The shootin1-cortactin interaction participates in netrin-1-induced F-actin adhesion coupling and in the promotion of traction forces for axon outgrowth.
Title: Shootin1-cortactin interaction mediates signal-force transduction for axon outgrowth.
Dock4 is highly concentrated in dendritic spines and implicated in spine formation via interaction with the actin-binding protein cortactin.
Title: Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation.
Findings unravel an unsuspected role for cortactin acetylation in the regulation of PSD95 dendritic clustering, which may work in concert with cortactin's role in spine development.
Title: Regulation of synapse composition by protein acetylation: the role of acetylated cortactin.
Data show that p140Cap suppresses the invasive properties of highly metastatic breast carcinoma cells by inhibiting cortactin-dependent cell motility.
Title: p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation.
Cortactin and dynamin-2 co-localize in growth cones of embryonic hippocampal neurons.
Title: Growth cone morphology and spreading are regulated by a dynamin-cortactin complex at point contacts in hippocampal neurons.
cortactin mediates interaction between podocalyxin and actin filaments in podocytes and that alteration of this interaction may play a role in the process of morphological change of podocytes.
Title: Cortactin interacts with podocalyxin and mediates morphological change of podocytes through its phosphorylation.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126596 (e-PCR)
- UniSTS:209712

RH142385 (e-PCR)
- UniSTS:231632

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables profilin binding	IEA Inferred from Electronic Annotation more info
enables profilin binding	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lamellipodium organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IC Inferred by Curator more info
involved_in modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in substrate-dependent cell migration, cell extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within substrate-dependent cell migration, cell extension	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
colocalizes_with actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in actin filament	IMP Inferred from Mutant Phenotype more info	PubMed
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle midzone	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle midzone	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	IEA Inferred from Electronic Annotation more info
located_in podosome	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
is_active_in site of polarized growth	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: src substrate cortactin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398643.1 → NP_001385572.1 src substrate cortactin isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6HYF4

Related

ENSRNOP00000050255.6, ENSRNOT00000047669.6

Conserved Domains (3) summary

cd11959
Location:492 → 544

SH3_Cortactin; Src homology 3 domain of Cortactin

pfam02218
Location:157 → 192

HS1_rep; Repeat in HS1/Cortactin

pfam15709
Location:357 → 400

DUF4670; Domain of unknown function (DUF4670)
NM_001398644.1 → NP_001385573.1 src substrate cortactin isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8L2URS9

Related

ENSRNOP00000075952.2, ENSRNOT00000092916.2

Conserved Domains (3) summary

cd11959
Location:418 → 470

SH3_Cortactin; Src homology 3 domain of Cortactin

pfam02218
Location:157 → 192

HS1_rep; Repeat in HS1/Cortactin

pfam15709
Location:283 → 326

DUF4670; Domain of unknown function (DUF4670)
NM_021868.3 → NP_068640.2 src substrate cortactin isoform 2

See identical proteins and their annotated locations for NP_068640.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

D3ZRB0, Q66HL2

UniProtKB/TrEMBL

A0A140TAH0

Related

ENSRNOP00000028283.3, ENSRNOT00000028283.6

Conserved Domains (3) summary

cd11959
Location:455 → 507

SH3_Cortactin; Src homology 3 domain of Cortactin

pfam02218
Location:231 → 266

HS1_rep; Repeat in HS1/Cortactin

cl05005
Location:299 → 362

TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

209029048..209064577 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272521.1 → XP_063128591.1 src substrate cortactin isoform X2

UniProtKB/Swiss-Prot

D3ZRB0, Q66HL2
XM_063272525.1 → XP_063128595.1 src substrate cortactin isoform X3

UniProtKB/TrEMBL

A0A8L2URS9
XM_063272517.1 → XP_063128587.1 src substrate cortactin isoform X1

UniProtKB/TrEMBL

A6HYF4
XM_063272519.1 → XP_063128589.1 src substrate cortactin isoform X1

UniProtKB/TrEMBL

A6HYF4
XM_063272523.1 → XP_063128593.1 src substrate cortactin isoform X2

UniProtKB/Swiss-Prot

D3ZRB0, Q66HL2
XM_063272530.1 → XP_063128600.1 src substrate cortactin isoform X5
XM_063272527.1 → XP_063128597.1 src substrate cortactin isoform X4
XM_063272532.1 → XP_063128602.1 src substrate cortactin isoform X6