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    Hs1bp3 HCLS1 binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 58240, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hs1bp3provided by MGI
    Official Full Name
    HCLS1 binding protein 3provided by MGI
    Primary source
    MGI:MGI:1913224
    See related
    Ensembl:ENSMUSG00000020605 AllianceGenome:MGI:1913224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in regulation of apoptotic process. Predicted to act upstream of or within T cell differentiation and cell surface receptor signaling pathway. Predicted to be located in endoplasmic reticulum and mitochondrion. Human ortholog(s) of this gene implicated in essential tremor 2. Orthologous to human HS1BP3 (HCLS1 binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 12.3), subcutaneous fat pad adult (RPKM 11.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 A1.1; 12 3.85 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (8363389..8393824)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (8313433..8343824)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31489 Neighboring gene predicted gene, 33037 Neighboring gene STARR-seq mESC enhancer starr_31490 Neighboring gene STARR-seq mESC enhancer starr_31491 Neighboring gene STARR-seq mESC enhancer starr_31492 Neighboring gene STARR-positive B cell enhancer ABC_E8885 Neighboring gene lipid droplet associated hydrolase Neighboring gene STARR-seq mESC enhancer starr_31493 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:8320448-8320557 Neighboring gene STARR-positive B cell enhancer mm9_chr12:8333629-8333930 Neighboring gene growth differentiation factor 7 Neighboring gene STARR-seq mESC enhancer starr_31498 Neighboring gene predicted gene, 48071 Neighboring gene predicted gene, 33134 Neighboring gene STARR-seq mESC enhancer starr_31500 Neighboring gene STARR-seq mESC enhancer starr_31501 Neighboring gene STARR-seq mESC enhancer starr_31502 Neighboring gene predicted gene, 51967

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. Takemoto Y, et al. Int Immunol, 1999 Dec. PMID 10590261
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HCLS1-binding protein 3
    Names
    HS1 binding protein 3
    HSP1BP-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021429.3 → NP_067404.2  HCLS1-binding protein 3

      See identical proteins and their annotated locations for NP_067404.2

      Status: VALIDATED

      Source sequence(s)
      AK040654, AK043263, AK084802, BC095977, BX630393
      Consensus CDS
      CCDS49024.1
      UniProtKB/Swiss-Prot
      E9QLQ4, Q3TC93, Q9Z1K1
      Related
      ENSMUSP00000020927.9, ENSMUST00000020927.10
      Conserved Domains (1) summary
      cd06868
      Location:19 → 138
      PX_HS1BP3; The phosphoinositide binding Phox Homology domain of HS1BP3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      8363389..8393824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157550.1 → XP_036013443.1  HCLS1-binding protein 3 isoform X1

      Conserved Domains (1) summary
      cd06868
      Location:19 → 138
      PX_HS1BP3; The phosphoinositide binding Phox Homology domain of HS1BP3

    2. XM_006515161.4 → XP_006515224.1  HCLS1-binding protein 3 isoform X3

      Conserved Domains (1) summary
      cl02563
      Location:1 → 28
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    3. XM_036157551.1 → XP_036013444.1  HCLS1-binding protein 3 isoform X2

      Conserved Domains (1) summary
      cd06868
      Location:1 → 105
      PX_HS1BP3; The phosphoinositide binding Phox Homology domain of HS1BP3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TC93.2 GenPept UniProtKB/Swiss-Prot:Q3TC93

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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