trmt5 tRNA methyltransferase 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trmt5provided by ZNC
Official Full Name: tRNA methyltransferase 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5978
See related: Ensembl:ENSDARG00000069278 AllianceGenome:ZFIN:ZDB-GENE-030131-5978
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fi28b08
Summary: Predicted to enable tRNA (guanine-N1-)-methyltransferase activity and tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity. Predicted to act upstream of or within tRNA methylation. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (31681960..31696858, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (31551510..31566334, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi28b08.x1 (e-PCR)
- UniSTS:197175

AW154524 (e-PCR)
- UniSTS:205907

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (guanine(37)-N1)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tRNA methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA (guanine(37)-N1)-methyltransferase

Names: TRM5 tRNA methyltransferase 5 homolog; tRNA (guanine-N(1)-)-methyltransferase

NP_001139055.1

EC 2.1.1.228

XP_009305612.1

EC 2.1.1.228

XP_009305613.1

EC 2.1.1.228

XP_021336289.1

EC 2.1.1.228

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145583.1 → NP_001139055.1 tRNA (guanine(37)-N1)-methyltransferase

See identical proteins and their annotated locations for NP_001139055.1

Status: PROVISIONAL

Source sequence(s)

BX537123

UniProtKB/Swiss-Prot

B8A5G9

Related

ENSDARP00000080424.4, ENSDART00000085989.5

Conserved Domains (2) summary

pfam02475
Location:183 → 384

Met_10; Met-10+ like-protein

pfam12847
Location:282 → 343

Methyltransf_18; Methyltransferase domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

31681960..31696858 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480614.1 → XP_021336289.1 tRNA (guanine(37)-N1)-methyltransferase isoform X2

UniProtKB/TrEMBL

A0A8M9QFG2

Conserved Domains (1) summary

cl27846
Location:1 → 210

Met_10; Met-10+ like-protein
XM_009307337.3 → XP_009305612.1 tRNA (guanine(37)-N1)-methyltransferase isoform X1

UniProtKB/TrEMBL

A0A8M3AZ45

Conserved Domains (2) summary

pfam02475
Location:152 → 353

Met_10; Met-10+ like-protein

pfam12847
Location:251 → 312

Methyltransf_18; Methyltransferase domain
XM_009307338.3 → XP_009305613.1 tRNA (guanine(37)-N1)-methyltransferase isoform X3

UniProtKB/TrEMBL

A0A8M3B822

Conserved Domains (1) summary

COG2520
Location:159 → 210

Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]