ntn4 netrin 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ntn4provided by ZNC
Official Full Name: netrin 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-050310-1
See related: Ensembl:ENSDARG00000102066 AllianceGenome:ZFIN:ZDB-GENE-050310-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Acts upstream of or within blood vessel morphogenesis. Predicted to be located in extracellular region. Predicted to be part of laminin complex. Is expressed in blood vessel; brain; neural rod; tail bud; and trunk. Orthologous to human NTN4 (netrin 4). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (19334416..19370713, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (19082059..19117827, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the crucial role of Netrin-4 in blood vessel formation and the involvement of protein kinases activation in Netrin-4-induced biological effects related to vascular development.
Title: Netrin-4 acts as a pro-angiogenic factor during zebrafish development.
netrin 4 is detected only at very low levels during early development
Title: Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in basement membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info
involved_in vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of laminin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: netrin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037686.1 → NP_001032775.1 netrin-4 precursor

See identical proteins and their annotated locations for NP_001032775.1

Status: PROVISIONAL

Source sequence(s)

AY928519

UniProtKB/TrEMBL

Q32SK8

Conserved Domains (5) summary

smart00180
Location:343 → 386

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:212 → 269

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03578
Location:444 → 556

NTR_netrin-4_like; NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta netrin) and similar proteins. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural ...

pfam00053
Location:281 → 340

Laminin_EGF; Laminin EGF domain

cl02806
Location:40 → 186

Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

19334416..19370713 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009303070.3 → XP_009301345.1 netrin-4 isoform X1

UniProtKB/TrEMBL

A0A0R4IFE9, A0A8M3B3Y4

Related

ENSDARP00000132076.1, ENSDART00000165680.3

Conserved Domains (5) summary

smart00180
Location:425 → 468

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:294 → 351

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03578
Location:526 → 637

NTR_netrin-4_like; NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta netrin) and similar proteins. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural ...

pfam00053
Location:363 → 422

Laminin_EGF; Laminin EGF domain

pfam00055
Location:89 → 292

Laminin_N; Laminin N-terminal (Domain VI)