lrrc39 leucine rich repeat containing 39 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lrrc39provided by ZNC
Official Full Name: leucine rich repeat containing 39provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-279
See related: Ensembl:ENSDARG00000071465 AllianceGenome:ZFIN:ZDB-GENE-050417-279
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:112088
Summary: Predicted to enable protein serine/threonine phosphatase activity. Acts upstream of or within cardiac muscle tissue morphogenesis; heart contraction; and sarcomere organization. Predicted to be located in M band. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in adaxial cell; floor plate; myotome; pectoral fin musculature; and somite. Orthologous to human LRRC39 (leucine rich repeat containing 39). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (16305942..16312217)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (16282180..16285912)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reveal myomasp/LRRC39 as a previously unrecognized component of an M-band-associated signaling pathway that regulates cardiomyocyte gene expression in response to biomechanical stress.
Title: Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in M band	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 39

Names: myomasp; myosin-interacting M-band-associated stress-responsive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017760.1 → NP_001017760.1 leucine-rich repeat-containing protein 39

See identical proteins and their annotated locations for NP_001017760.1

Status: PROVISIONAL

Source sequence(s)

BC093194

UniProtKB/Swiss-Prot

F1R6I3

Related

ENSDARP00000096455.4, ENSDART00000105678.6

Conserved Domains (3) summary

cd00116
Location:99 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:113 → 135

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:158 → 214

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

16305942..16312217

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021469325.1 → XP_021325000.1 leucine-rich repeat-containing protein 39 isoform X1

UniProtKB/Swiss-Prot

A8E5F1, F1R6I3, Q567F2, Q66I91

UniProtKB/TrEMBL

A0A8M9PV96

Conserved Domains (2) summary

COG4886
Location:106 → 286

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:113 → 135

LRR_RI; leucine-rich repeat [structural motif]