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    PIGY phosphatidylinositol glycan anchor biosynthesis class Y [ Bos taurus (cattle) ]

    Gene ID: 514374, updated on 4-Apr-2024

    Summary

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    Gene symbol
    PIGY
    Gene description
    phosphatidylinositol glycan anchor biosynthesis class Y
    See related
    BGD:BT19000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PIG-Y
    Summary
    The protein encoded by this gene is part of the GPI-N-acetylglucosaminyltransferase (GIP-GnT) complex which initiates the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is synthesized in the endoplasmic reticulum and serves as an anchor for many surface proteins. Proteins containing GPI anchors can have an important role in cell-cell interactions. The transcript for this gene is bicistronic. The downstream open reading frame encodes this GPI-GnT complex protein, while the upstream open reading frame encodes a protein with unknown function, as represented by GeneID:100996942. [provided by RefSeq, Aug 2012]
    Orthologs
    human all
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    Genomic context

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    See PIGY in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (36250626..36253481)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 13 member A Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 3 Neighboring gene nucleosome assembly protein 1 like 5 Neighboring gene PIGY upstream open reading frame Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 5 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Murakami Y, et al. Mol Biol Cell, 2005 Nov. PMID 16162815, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC134017

    General protein information

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    Preferred Names
    phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
    Names
    phosphatidylinositol-glycan biosynthesis class Y protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270946.1 → NP_001257875.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

      See identical proteins and their annotated locations for NP_001257875.1

      Status: VALIDATED

      Source sequence(s)
      EH163221, EV733664, GH307127, NKLS02000006
      UniProtKB/Swiss-Prot
      P0C1N9
      Conserved Domains (1) summary
      pfam15159
      Location:8 → 71
      PIG-Y; Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      36250626..36253481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C1N9.1 GenPept UniProtKB/Swiss-Prot:P0C1N9

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