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    ADCY6 adenylate cyclase 6 [ Bos taurus (cattle) ]

    Gene ID: 509936, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ADCY6provided by VGNC
    Official Full Name
    adenylate cyclase 6provided by VGNC
    Primary source
    VGNC:VGNC:25647
    See related
    BGD:BT15041; Ensembl:ENSBTAG00000005464
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (30987950..31009389)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 23 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 3 Neighboring gene uncharacterized LOC132345269 Neighboring gene testis expressed 49 Neighboring gene cyclin T1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes. Ostrom RS, et al. J Biol Chem, 2004 May 7. PMID 15007069
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. co-localization of multiple signaling components in lipid rafts provides key spatial regulation of AC6 (ADCY6) activity.
      Title: Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenylate cyclase type 6
    NP_001137349.1
    XP_010803264.1
    XP_024847351.1
    XP_024847352.1
    XP_059742241.1
    XP_059742242.1
    XP_059742243.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143877.1 → NP_001137349.1  adenylate cyclase type 6

      See identical proteins and their annotated locations for NP_001137349.1

      Status: INFERRED

      Source sequence(s)
      NKLS02000005
      UniProtKB/TrEMBL
      E1B9K3
      Related
      ENSBTAP00000089770.1, ENSBTAT00000117179.1
      Conserved Domains (3) summary
      pfam00211
      Location:968 → 1162
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:580 → 666
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:16 → 366
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      30987950..31009389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010804962.4 → XP_010803264.1  adenylate cyclase type 6 isoform X1

      See identical proteins and their annotated locations for XP_010803264.1

      UniProtKB/TrEMBL
      E1B9K3
      Conserved Domains (3) summary
      pfam00211
      Location:968 → 1162
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:580 → 666
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:16 → 366
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    2. XM_024991584.2 → XP_024847352.1  adenylate cyclase type 6 isoform X1

      UniProtKB/TrEMBL
      E1B9K3
      Conserved Domains (3) summary
      pfam00211
      Location:968 → 1162
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:580 → 666
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:16 → 366
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    3. XM_024991583.2 → XP_024847351.1  adenylate cyclase type 6 isoform X1

      UniProtKB/TrEMBL
      E1B9K3
      Related
      ENSBTAP00000007187.4, ENSBTAT00000007187.6
      Conserved Domains (3) summary
      pfam00211
      Location:968 → 1162
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:580 → 666
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:16 → 366
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    4. XM_059886258.1 → XP_059742241.1  adenylate cyclase type 6 isoform X1

      UniProtKB/TrEMBL
      E1B9K3

    5. XM_059886259.1 → XP_059742242.1  adenylate cyclase type 6 isoform X2

    6. XM_059886260.1 → XP_059742243.1  adenylate cyclase type 6 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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