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    LRRC8A leucine rich repeat containing 8 VRAC subunit A [ Bos taurus (cattle) ]

    Gene ID: 505605, updated on 5-Mar-2024

    Summary

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    Official Symbol
    LRRC8Aprovided by VGNC
    Official Full Name
    leucine rich repeat containing 8 VRAC subunit Aprovided by VGNC
    Primary source
    VGNC:VGNC:31029
    See related
    BGD:BT10901; Ensembl:ENSBTAG00000013030
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    LLRC8A
    Orthologs
    human mouse all
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    Genomic context

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    See LRRC8A in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (99394187..99421579)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene kynurenine aminotransferase 1 Neighboring gene kynurenine--oxoglutarate transaminase 1 Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene dolichol kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC139701

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    volume-regulated anion channel subunit LRRC8A
    Names
    leucine rich repeat containing 8 family member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076807.1 → NP_001070275.1  volume-regulated anion channel subunit LRRC8A

      See identical proteins and their annotated locations for NP_001070275.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123432
      UniProtKB/TrEMBL
      Q08E42
      Related
      ENSBTAP00000017322.5, ENSBTAT00000017322.6
      Conserved Domains (3) summary
      COG4886
      Location:510 → 767
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:546 → 568
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 340
      Pannexin_like; Pannexin-like TM region of LRRC8

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      99394187..99421579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024998390.2 → XP_024854158.1  volume-regulated anion channel subunit LRRC8A isoform X1

      UniProtKB/TrEMBL
      Q08E42
      Conserved Domains (3) summary
      COG4886
      Location:510 → 767
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:546 → 568
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 340
      Pannexin_like; Pannexin-like TM region of LRRC8

    2. XM_005213203.5 → XP_005213260.1  volume-regulated anion channel subunit LRRC8A isoform X1

      See identical proteins and their annotated locations for XP_005213260.1

      UniProtKB/TrEMBL
      Q08E42
      Conserved Domains (3) summary
      COG4886
      Location:510 → 767
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:546 → 568
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 340
      Pannexin_like; Pannexin-like TM region of LRRC8

    3. XM_024998391.2 → XP_024854159.1  volume-regulated anion channel subunit LRRC8A isoform X1

      UniProtKB/TrEMBL
      Q08E42
      Conserved Domains (3) summary
      COG4886
      Location:510 → 767
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:546 → 568
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 340
      Pannexin_like; Pannexin-like TM region of LRRC8
    Nucleotide Protein Strain
    Heading Accession and Version

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