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    Eqtn equatorin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500502, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Eqtnprovided by RGD
    Official Full Name
    equatorinprovided by RGD
    Primary source
    RGD:1563332
    See related
    Ensembl:ENSRNOG00000026323 AllianceGenome:RGD:1563332
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Afaf
    Summary
    Predicted to be involved in acrosomal vesicle exocytosis; endocytosis; and fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in acrosomal membrane; early endosome; and nucleus. Predicted to be active in inner acrosomal membrane; outer acrosomal membrane; and plasma membrane. Orthologous to human EQTN (equatorin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 75.3), Testes (RPKM 30.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (114851981..114880683, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (109734495..109762048, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (113852191..113881142, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 74 Neighboring gene microRNA 872 Neighboring gene TEK receptor tyrosine kinase Neighboring gene myb-like, SWIRM and MPN domains 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC120102921

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A model of the acrosome reaction progression via the acrosomal membrane-anchored protein equatorin. Yoshida K, et al. Reproduction, 2010 Mar. PMID 20032212
    2. Equatorin: identification and characterization of the epitope of the MN9 antibody in the mouse. Yamatoya K, et al. Biol Reprod, 2009 Nov. PMID 19605790
    3. An MN9 antigenic molecule, equatorin, is required for successful sperm-oocyte fusion in mice. Toshimori K, et al. Biol Reprod, 1998 Jul. PMID 9674989
    4. Acrosome formation-associated factor is involved in fertilization. Hu XQ, et al. Fertil Steril, 2010 Mar 15. PMID 19285662
    5. Afaf, a novel vesicle membrane protein, is related to acrosome formation in murine testis. Li YC, et al. FEBS Lett, 2006 Jul 24. PMID 16831425

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in acrosomal vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acrosomal vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within acrosomal vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fusion of sperm to egg plasma membrane involved in single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in inner acrosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in inner acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inner acrosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in outer acrosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in outer acrosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    equatorin
    Names
    Acrosome formation associated factor
    acrosome formation-associated factor
    equatorin, sperm acrosome associated

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039345.1 → NP_001034434.1  equatorin precursor

      See identical proteins and their annotated locations for NP_001034434.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ336136
      UniProtKB/Swiss-Prot
      F1LP31, Q2LCV6
      Conserved Domains (1) summary
      pfam15339
      Location:63 → 245
      Afaf; Acrosome formation-associated factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      114851981..114880683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110577.2 → XP_038966505.1  equatorin isoform X1

      UniProtKB/Swiss-Prot
      F1LP31, Q2LCV6
      UniProtKB/TrEMBL
      A0A8L2QIL8
      Related
      ENSRNOP00000034172.5
      Conserved Domains (1) summary
      pfam15339
      Location:63 → 250
      Afaf; Acrosome formation-associated factor

    RNA

    1. XR_005504519.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2LCV6.2 GenPept UniProtKB/Swiss-Prot:Q2LCV6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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