HTR1A 5-hydroxytryptamine receptor 1A [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: HTR1Aprovided by VGNC
Official Full Name: 5-hydroxytryptamine receptor 1Aprovided by VGNC
Primary source: VGNC:VGNC:41823
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (50490014..50491285, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (46962303..46963574, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (49236031..49237302, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (47550689..47551960, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (48341999..48343270, complement)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The obtained results provide evidence of the inhibitory role of 5-HT1A receptors in modulating visceral pain sensitivity and the possibility of an exciting effect of their activation on the cardiovascular system
Title: Antinociceptive effect of the agonist of 5-HT1A receptors buspirone in the model of abdominal pain in dogs.
5-HT and the 5-HT1A receptor may be involved in the differentiation of canine mast cell tumors and in the microvascular complications associated with these neoplasms.
Title: Expression of serotonin and its 5-HT1A receptor in canine cutaneous mast cell tumours.
Report differential sensitivity to established and novel dopamine D2/5-HT(1A) antipsychotic compounds in dog model of emesis.
Title: Apomorphine-induced emesis in dogs: differential sensitivity to established and novel dopamine D2/5-HT(1A) antipsychotic compounds.
Gene does not play a major role in the variation in aggression in the Golden Retrievers.
Title: Evaluation of the serotonergic genes htr1A, htr1B, htr2A, and slc6A4 in aggressive behavior of golden retriever dogs.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of hormone secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1A

Names: 5-HT-1A; 5-HT1A receptor; serotonin receptor 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012397.1 → NP_001012397.1 5-hydroxytryptamine receptor 1A

See identical proteins and their annotated locations for NP_001012397.1

Status: PROVISIONAL

Source sequence(s)

AY204570

UniProtKB/Swiss-Prot

Q6XXX9

UniProtKB/TrEMBL

A0A8C0L9N8, Q8HYB0

Conserved Domains (1) summary

cd15330
Location:37 → 411

7tmA_5-HT1A_vertebrates; serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors