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    CPAMD8 C3 and PZP like alpha-2-macroglobulin domain containing 8 [ Canis lupus familiaris (dog) ]

    Gene ID: 484845, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CPAMD8provided by VGNC
    Official Full Name
    C3 and PZP like alpha-2-macroglobulin domain containing 8provided by VGNC
    Primary source
    VGNC:VGNC:39548
    See related
    Ensembl:ENSCAFG00845029496
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human all
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    Genomic context

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    Location:
    chromosome: 20
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (46146643..46223500)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (45573885..45650980)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (46069060..46145901)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (45382920..45459688)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (45792837..45870299)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene myosin IXB Neighboring gene HAUS augmin like complex subunit 8 Neighboring gene pancreatic progenitor cell differentiation and proliferation factor-like Neighboring gene uncharacterized LOC102153011 Neighboring gene F2R like thrombin or trypsin receptor 3 Neighboring gene SIN3 transcription regulator family member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      46146643..46223500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038428269.1 → XP_038284197.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (9) summary
      smart00280
      Location:1710 → 1754
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1138 → 1437
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1567 → 1657
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    2. XM_038428272.1 → XP_038284200.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (9) summary
      smart00280
      Location:1637 → 1681
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1138 → 1425
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1494 → 1584
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    3. XM_038428273.1 → XP_038284201.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X5

      UniProtKB/TrEMBL
      A0A8C0STH4
      Conserved Domains (8) summary
      smart00280
      Location:1585 → 1629
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1013 → 1312
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1442 → 1532
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:868 → 969
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    4. XM_038428271.1 → XP_038284199.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (8) summary
      smart00280
      Location:1653 → 1697
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1081 → 1380
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:701 → 792
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1510 → 1600
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:408 → 577
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:936 → 1037
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    5. XM_038428270.1 → XP_038284198.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Related
      ENSCAFP00845040972.1, ENSCAFT00845052236.1
      Conserved Domains (9) summary
      smart00280
      Location:1699 → 1743
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1127 → 1426
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:747 → 838
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1556 → 1646
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:454 → 623
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:982 → 1083
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:349 → 408
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:222 → 297
      MG3; Macroglobulin domain MG3

    6. XM_038428275.1 → XP_038284203.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X7

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (7) summary
      cd02897
      Location:1138 → 1437
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    7. XM_038428276.1 → XP_038284204.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X8

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (7) summary
      cd02897
      Location:1138 → 1437
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    8. XM_038428274.1 → XP_038284202.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X6

      UniProtKB/TrEMBL
      A0A8C0QYS0
      Conserved Domains (8) summary
      smart00280
      Location:1537 → 1581
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:965 → 1264
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:585 → 676
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1394 → 1484
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:292 → 461
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:820 → 921
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:187 → 246
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:62 → 135
      MG3; Macroglobulin domain MG3

    RNA

    1. XR_005298031.1 RNA Sequence

    2. XR_005298032.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049280.1 Alternate UMICH_Zoey_3.1

      Range
      45382920..45459688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038503910.1 → XP_038359838.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X9

    2. XM_038503913.1 → XP_038359841.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X12

    3. XM_038503912.1 → XP_038359840.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X11

    4. XM_038503917.1 → XP_038359845.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X16

    5. XM_038503911.1 → XP_038359839.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X10

    6. XM_038503915.1 → XP_038359843.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X14

    7. XM_038503916.1 → XP_038359844.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X15

    8. XM_038503914.1 → XP_038359842.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X13

    RNA

    1. XR_005341226.1 RNA Sequence

    2. XR_005341227.1 RNA Sequence

    3. XR_005341229.1 RNA Sequence

    4. XR_005341228.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      45792837..45870299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038631091.1 → XP_038487019.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1

      Conserved Domains (9) summary
      smart00280
      Location:1710 → 1754
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1138 → 1437
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1567 → 1657
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    2. XM_038631094.1 → XP_038487022.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X4

      Conserved Domains (9) summary
      smart00280
      Location:1637 → 1681
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1138 → 1425
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1494 → 1584
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    3. XM_038631095.1 → XP_038487023.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X5

    4. XM_038631093.1 → XP_038487021.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X3

      Conserved Domains (8) summary
      smart00280
      Location:1653 → 1697
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1081 → 1380
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:701 → 792
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1510 → 1600
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:408 → 577
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:936 → 1037
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    5. XM_038631092.1 → XP_038487020.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X2

      Conserved Domains (9) summary
      smart00280
      Location:1699 → 1743
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1127 → 1426
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:747 → 838
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1556 → 1646
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:454 → 623
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:982 → 1083
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:349 → 408
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:222 → 297
      MG3; Macroglobulin domain MG3

    6. XM_038631097.1 → XP_038487025.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X7

    7. XM_038631098.1 → XP_038487026.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X8

      Conserved Domains (7) summary
      cd02897
      Location:1138 → 1437
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    8. XM_038631096.1 → XP_038487024.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X6

    RNA

    1. XR_005409056.1 RNA Sequence

    2. XR_005409057.1 RNA Sequence

    3. XR_005409059.1 RNA Sequence

    4. XR_005409058.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      46069060..46145901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038566939.1 → XP_038422867.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (9) summary
      smart00280
      Location:1710 → 1754
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1138 → 1437
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1567 → 1657
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    2. XM_038566942.1 → XP_038422870.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (9) summary
      smart00280
      Location:1637 → 1681
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1138 → 1425
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1494 → 1584
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    3. XM_038566943.1 → XP_038422871.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X5

      UniProtKB/TrEMBL
      A0A8C0STH4

    4. XM_038566941.1 → XP_038422869.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (8) summary
      smart00280
      Location:1653 → 1697
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1081 → 1380
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:701 → 792
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1510 → 1600
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:408 → 577
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:936 → 1037
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    5. XM_038566940.1 → XP_038422868.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (9) summary
      smart00280
      Location:1699 → 1743
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1127 → 1426
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:747 → 838
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1556 → 1646
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:454 → 623
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:982 → 1083
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:349 → 408
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:222 → 297
      MG3; Macroglobulin domain MG3

    6. XM_038566945.1 → XP_038422873.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X17

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (7) summary
      cd02897
      Location:1138 → 1437
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    7. XM_038566946.1 → XP_038422874.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X8

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (7) summary
      cd02897
      Location:1138 → 1437
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    8. XM_038566944.1 → XP_038422872.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X6

      UniProtKB/TrEMBL
      A0A8C0QYS0

    RNA

    1. XR_005375031.1 RNA Sequence

    2. XR_005375032.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      45573885..45650980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038454993.1 → XP_038310921.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (9) summary
      smart00280
      Location:1710 → 1754
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1138 → 1437
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1567 → 1657
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    2. XM_038454995.1 → XP_038310923.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (9) summary
      smart00280
      Location:1637 → 1681
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1138 → 1425
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1494 → 1584
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    3. XM_038454996.1 → XP_038310924.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X5

      UniProtKB/TrEMBL
      A0A8C0STH4
      Conserved Domains (8) summary
      smart00280
      Location:1585 → 1629
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1013 → 1312
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1442 → 1532
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:868 → 969
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    4. XM_038454994.1 → XP_038310922.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (8) summary
      smart00280
      Location:1653 → 1697
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1081 → 1380
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:701 → 792
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1510 → 1600
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:408 → 577
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:936 → 1037
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    5. XM_014122136.3 → XP_013977611.2  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (9) summary
      smart00280
      Location:1699 → 1743
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1127 → 1426
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:747 → 838
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1556 → 1646
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:454 → 623
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:982 → 1083
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:349 → 408
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:222 → 297
      MG3; Macroglobulin domain MG3

    6. XM_038454997.1 → XP_038310925.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X7

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (7) summary
      cd02897
      Location:1138 → 1437
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    7. XM_022406915.2 → XP_022262623.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X8

      UniProtKB/TrEMBL
      A0A8I3Q3S3, A0A8P0SJV4
      Conserved Domains (7) summary
      cd02897
      Location:1138 → 1437
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07703
      Location:465 → 634
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:993 → 1094
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:360 → 419
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:235 → 308
      MG3; Macroglobulin domain MG3

    8. XM_022406914.2 → XP_022262622.2  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X6

      UniProtKB/TrEMBL
      A0A8C0QYS0
      Conserved Domains (8) summary
      smart00280
      Location:1537 → 1581
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:965 → 1264
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:585 → 676
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1394 → 1484
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:292 → 461
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:820 → 921
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      pfam17789
      Location:187 → 246
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:62 → 135
      MG3; Macroglobulin domain MG3

    RNA

    1. XR_005312401.1 RNA Sequence

    2. XR_005312402.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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