IRAK2 interleukin 1 receptor associated kinase 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: IRAK2provided by VGNC
Official Full Name: interleukin 1 receptor associated kinase 2provided by VGNC
Primary source: VGNC:VGNC:103685
See related: Ensembl:ENSCAFG00845008041
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	20	NC_051824.1 (8163720..8226516, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	20	NC_006602.4 (8168204..8230998, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	20	NC_049241.1 (8204711..8267937, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	20	NC_049280.1 (7885354..7948798, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	20	NC_049761.1 (8231080..8293927, complement)

Chromosome 20 - NC_051824.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-497 induces apoptosis by the IRAK2/NF-kappaB axis in the canine mammary tumour.
Title: miR-497 induces apoptosis by the IRAK2/NF-κB axis in the canine mammary tumour.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in interleukin-1-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-1 receptor-associated kinase-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051824.1 Reference ROS_Cfam_1.0

Range

8163720..8226516 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038426950.1 → XP_038282878.1 interleukin-1 receptor-associated kinase-like 2 isoform X3

UniProtKB/TrEMBL

A0A8C0K5A6, A0A8I3N7V1, A0A8P0TSJ6

Related

ENSCAFP00845011037.1, ENSCAFT00845014236.1

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:223 → 490

PKc_like; Protein Kinases, catalytic domain
XM_038426948.1 → XP_038282876.1 interleukin-1 receptor-associated kinase-like 2 isoform X2

UniProtKB/TrEMBL

A0A8C0K5A6

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:211 → 499

PKc_like; Protein Kinases, catalytic domain
XM_038426947.1 → XP_038282875.1 interleukin-1 receptor-associated kinase-like 2 isoform X1

UniProtKB/TrEMBL

A0A8C0K5A6, A0A8I3N5F6, A0A8P0SAN8

Related

ENSCAFP00845010985.1, ENSCAFT00845014169.1

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:223 → 511

PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049280.1 Alternate UMICH_Zoey_3.1

Range

7885354..7948798 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038502742.1 → XP_038358670.1 interleukin-1 receptor-associated kinase-like 2 isoform X3

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:223 → 490

PKc_like; Protein Kinases, catalytic domain
XM_038502741.1 → XP_038358669.1 interleukin-1 receptor-associated kinase-like 2 isoform X2

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:211 → 499

PKc_like; Protein Kinases, catalytic domain
XM_038502740.1 → XP_038358668.1 interleukin-1 receptor-associated kinase-like 2 isoform X1

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:223 → 511

PKc_like; Protein Kinases, catalytic domain

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049761.1 Alternate UNSW_CanFamBas_1.0

Range

8231080..8293927 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038629795.1 → XP_038485723.1 interleukin-1 receptor-associated kinase-like 2 isoform X2

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:211 → 499

PKc_like; Protein Kinases, catalytic domain
XM_038629796.1 → XP_038485724.1 interleukin-1 receptor-associated kinase-like 2 isoform X3

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:223 → 490

PKc_like; Protein Kinases, catalytic domain
XM_038629794.1 → XP_038485722.1 interleukin-1 receptor-associated kinase-like 2 isoform X1

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:223 → 511

PKc_like; Protein Kinases, catalytic domain

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049241.1 Alternate UU_Cfam_GSD_1.0

Range

8204711..8267937 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038565661.1 → XP_038421589.1 interleukin-1 receptor-associated kinase-like 2 isoform X3

UniProtKB/TrEMBL

A0A8C0K5A6, A0A8I3N7V1, A0A8P0TSJ6

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:223 → 490

PKc_like; Protein Kinases, catalytic domain
XM_038565660.1 → XP_038421588.1 interleukin-1 receptor-associated kinase-like 2 isoform X2

UniProtKB/TrEMBL

A0A8C0K5A6

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:211 → 499

PKc_like; Protein Kinases, catalytic domain
XM_038565659.1 → XP_038421587.1 interleukin-1 receptor-associated kinase-like 2 isoform X1

UniProtKB/TrEMBL

A0A8C0K5A6, A0A8I3N5F6, A0A8P0SAN8

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:223 → 511

PKc_like; Protein Kinases, catalytic domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

8168204..8230998 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_014121695.3 → XP_013977170.1 interleukin-1 receptor-associated kinase-like 2 isoform X3

UniProtKB/TrEMBL

A0A8C0K5A6, A0A8I3N7V1, A0A8P0TSJ6

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:223 → 490

PKc_like; Protein Kinases, catalytic domain
XM_005632168.4 → XP_005632225.1 interleukin-1 receptor-associated kinase-like 2 isoform X2

UniProtKB/TrEMBL

A0A8C0K5A6

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:211 → 499

PKc_like; Protein Kinases, catalytic domain
XM_014121694.3 → XP_013977169.1 interleukin-1 receptor-associated kinase-like 2 isoform X1

UniProtKB/TrEMBL

A0A8C0K5A6, A0A8I3N5F6, A0A8P0SAN8

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:223 → 511

PKc_like; Protein Kinases, catalytic domain