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    CRHR2 corticotropin releasing hormone receptor 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 482384, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CRHR2provided by VGNC
    Official Full Name
    corticotropin releasing hormone receptor 2provided by VGNC
    Primary source
    VGNC:VGNC:39611
    See related
    Ensembl:ENSCAFG00845020144
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 14 NC_051818.1 (43307910..43355188, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 14 NC_006596.4 (42799432..42846743, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 14 NC_049235.1 (43461123..43508563, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 14 NC_049274.1 (43423758..43471041, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 14 NC_049755.1 (43099719..43147031, complement)

    Chromosome 14 - NC_051818.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111098816 Neighboring gene gamma-glutamylcyclotransferase Neighboring gene glycyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC102153651 Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene uncharacterized LOC119867320

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables corticotrophin-releasing factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables corticotropin-releasing hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    corticotropin-releasing factor receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051818.1 Reference ROS_Cfam_1.0

      Range
      43307910..43355188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038686854.1 → XP_038542782.1  corticotropin-releasing factor receptor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0MQD1
      Conserved Domains (2) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd15446
      Location:138 → 401
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    2. XM_038686858.1 → XP_038542786.1  corticotropin-releasing factor receptor 2 isoform X2

      Conserved Domains (3) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd14964
      Location:141 → 166
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:139 → 332
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_038686853.1 → XP_038542781.1  corticotropin-releasing factor receptor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JT57, A0A8C0MQD1, A0A8C0QKV4, A0A8I3PB95
      Related
      ENSCAFP00845027768.1, ENSCAFT00845035482.1
      Conserved Domains (2) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd15446
      Location:139 → 402
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    4. XM_038686855.1 → XP_038542783.1  corticotropin-releasing factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JTT8, A0A8C0MQD1, A0A8C0RFC3
      Conserved Domains (2) summary
      smart00008
      Location:60 → 131
      HormR; Domain present in hormone receptors
      cd15446
      Location:137 → 400
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    5. XM_038686857.1 → XP_038542785.1  corticotropin-releasing factor receptor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I3P1G6, A0A8P0NVC6
      Conserved Domains (2) summary
      smart00008
      Location:36 → 107
      HormR; Domain present in hormone receptors
      cd15446
      Location:112 → 375
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    6. XM_038686856.1 → XP_038542784.1  corticotropin-releasing factor receptor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8C0JUC7, A0A8C0Q9N6, A0A8I3P1G6, A0A8I3PCS7, A0A8P0NVC6
      Related
      ENSCAFP00845027957.1, ENSCAFT00845035732.1
      Conserved Domains (2) summary
      smart00008
      Location:36 → 107
      HormR; Domain present in hormone receptors
      cd15446
      Location:113 → 376
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049274.1 Alternate UMICH_Zoey_3.1

      Range
      43423758..43471041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038494964.1 → XP_038350892.1  corticotropin-releasing factor receptor 2 isoform X4

      Conserved Domains (2) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd15446
      Location:138 → 401
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    2. XM_038494969.1 → XP_038350897.1  corticotropin-releasing factor receptor 2 isoform X2

      Conserved Domains (3) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd14964
      Location:141 → 166
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:139 → 332
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_038494963.1 → XP_038350891.1  corticotropin-releasing factor receptor 2 isoform X3

      Conserved Domains (2) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd15446
      Location:139 → 402
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    4. XM_038494965.1 → XP_038350893.1  corticotropin-releasing factor receptor 2 isoform X1

      Conserved Domains (2) summary
      smart00008
      Location:60 → 131
      HormR; Domain present in hormone receptors
      cd15446
      Location:137 → 400
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    5. XM_038494967.1 → XP_038350895.1  corticotropin-releasing factor receptor 2 isoform X6

      Conserved Domains (2) summary
      smart00008
      Location:36 → 107
      HormR; Domain present in hormone receptors
      cd15446
      Location:112 → 375
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    6. XM_038494966.1 → XP_038350894.1  corticotropin-releasing factor receptor 2 isoform X5

      Conserved Domains (2) summary
      smart00008
      Location:36 → 107
      HormR; Domain present in hormone receptors
      cd15446
      Location:113 → 376
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    7. XM_038494968.1 → XP_038350896.1  corticotropin-releasing factor receptor 2 isoform X7

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049755.1 Alternate UNSW_CanFamBas_1.0

      Range
      43099719..43147031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038621172.1 → XP_038477100.1  corticotropin-releasing factor receptor 2 isoform X4

    2. XM_038621171.1 → XP_038477099.1  corticotropin-releasing factor receptor 2 isoform X3

    3. XM_038621174.1 → XP_038477102.1  corticotropin-releasing factor receptor 2 isoform X6

      Conserved Domains (2) summary
      smart00008
      Location:36 → 107
      HormR; Domain present in hormone receptors
      cd15446
      Location:112 → 375
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    4. XM_038621173.1 → XP_038477101.1  corticotropin-releasing factor receptor 2 isoform X5

      Conserved Domains (2) summary
      smart00008
      Location:36 → 107
      HormR; Domain present in hormone receptors
      cd15446
      Location:113 → 376
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049235.1 Alternate UU_Cfam_GSD_1.0

      Range
      43461123..43508563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038557233.1 → XP_038413161.1  corticotropin-releasing factor receptor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0MQD1
      Conserved Domains (2) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd15446
      Location:138 → 401
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    2. XM_038557237.1 → XP_038413165.1  corticotropin-releasing factor receptor 2 isoform X2

      Conserved Domains (3) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd14964
      Location:141 → 166
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:139 → 332
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_038557232.1 → XP_038413160.1  corticotropin-releasing factor receptor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JT57, A0A8C0MQD1, A0A8C0QKV4, A0A8I3PB95
      Conserved Domains (2) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd15446
      Location:139 → 402
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    4. XM_038557234.1 → XP_038413162.1  corticotropin-releasing factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JTT8, A0A8C0MQD1, A0A8C0RFC3
      Conserved Domains (2) summary
      smart00008
      Location:60 → 131
      HormR; Domain present in hormone receptors
      cd15446
      Location:137 → 400
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    5. XM_038557236.1 → XP_038413164.1  corticotropin-releasing factor receptor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I3P1G6, A0A8P0NVC6
      Conserved Domains (2) summary
      smart00008
      Location:36 → 107
      HormR; Domain present in hormone receptors
      cd15446
      Location:112 → 375
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    6. XM_038557235.1 → XP_038413163.1  corticotropin-releasing factor receptor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8C0JUC7, A0A8C0Q9N6, A0A8I3P1G6, A0A8I3PCS7, A0A8P0NVC6
      Conserved Domains (2) summary
      smart00008
      Location:36 → 107
      HormR; Domain present in hormone receptors
      cd15446
      Location:113 → 376
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006596.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      42799432..42846743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005628683.4 → XP_005628740.2  corticotropin-releasing factor receptor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0MQD1
      Conserved Domains (2) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd15446
      Location:138 → 401
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    2. XM_005628687.4 → XP_005628744.2  corticotropin-releasing factor receptor 2 isoform X2

      Conserved Domains (3) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd14964
      Location:141 → 166
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:139 → 332
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_005628682.4 → XP_005628739.2  corticotropin-releasing factor receptor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JT57, A0A8C0MQD1, A0A8C0QKV4, A0A8I3PB95
      Conserved Domains (2) summary
      smart00008
      Location:62 → 133
      HormR; Domain present in hormone receptors
      cd15446
      Location:139 → 402
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    4. XM_005628684.3 → XP_005628741.2  corticotropin-releasing factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JTT8, A0A8C0MQD1, A0A8C0RFC3
      Conserved Domains (2) summary
      smart00008
      Location:60 → 131
      HormR; Domain present in hormone receptors
      cd15446
      Location:137 → 400
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    5. XM_539501.6 → XP_539501.4  corticotropin-releasing factor receptor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I3P1G6, A0A8P0NVC6
      Conserved Domains (2) summary
      smart00008
      Location:36 → 107
      HormR; Domain present in hormone receptors
      cd15446
      Location:112 → 375
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    6. XM_005628686.3 → XP_005628743.2  corticotropin-releasing factor receptor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8C0JUC7, A0A8C0Q9N6, A0A8I3P1G6, A0A8I3PCS7, A0A8P0NVC6
      Conserved Domains (2) summary
      smart00008
      Location:36 → 107
      HormR; Domain present in hormone receptors
      cd15446
      Location:113 → 376
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
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