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    POLK DNA polymerase kappa [ Canis lupus familiaris (dog) ]

    Gene ID: 479180, updated on 5-Mar-2024

    Summary

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    Official Symbol
    POLKprovided by VGNC
    Official Full Name
    DNA polymerase kappaprovided by VGNC
    Primary source
    VGNC:VGNC:44785
    See related
    Ensembl:ENSCAFG00845011326
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (30716706..30790391, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (32036886..32103334, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (31002435..31068944, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (30654748..30720406, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (30624393..30691008, complement)

    Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit F-like Neighboring gene POC5 centriolar protein Neighboring gene uncharacterized LOC119871178 Neighboring gene ceramide transporter 1 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC111095175

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in error-prone translesion synthesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase kappa
    XP_013967743.1
    XP_013967744.1
    XP_013967745.1
    XP_013967746.1
    XP_013967747.1
    XP_013967749.1
    XP_022272493.1
    XP_022272494.1
    XP_038327524.1
    XP_038327525.1
    XP_038327526.1
    XP_038327527.1
    XP_038327528.1
    XP_038327529.1
    XP_038327530.1
    XP_038327531.1
    XP_038327532.1
    XP_038328333.1
    XP_038388456.1
    XP_038388457.1
    XP_038388458.1
    XP_038388459.1
    XP_038388460.1
    XP_038388461.1
    XP_038388462.1
    XP_038388463.1
    XP_038452739.1
    XP_038452740.1
    XP_038452741.1
    XP_038452742.1
    XP_038452743.1
    XP_038452744.1
    XP_038452745.1
    XP_038452746.1
    XP_038452747.1
    XP_038516949.1
    XP_038516950.1
    XP_038516951.1
    XP_038516952.1
    XP_038516953.1
    XP_038516954.1
    XP_038516955.1
    XP_038516957.1
    XP_038516958.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051807.1 Reference ROS_Cfam_1.0

      Range
      30716706..30790391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038661023.1 → XP_038516951.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    2. XM_038661025.1 → XP_038516953.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Related
      ENSCAFP00845015755.1, ENSCAFT00845020103.1
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    3. XM_038661029.1 → XP_038516957.1  DNA polymerase kappa isoform X3

      UniProtKB/TrEMBL
      A0A8C0PTJ1
      Conserved Domains (3) summary
      cd03586
      Location:104 → 436
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:498 → 625
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cl02765
      Location:687 → 713
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain

    4. XM_038661030.1 → XP_038516958.1  DNA polymerase kappa isoform X4

      UniProtKB/TrEMBL
      A0A8C0PTJ1
      Conserved Domains (3) summary
      smart00734
      Location:526 → 552
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:80 → 421
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:483 → 610
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    5. XM_038661027.1 → XP_038516955.1  DNA polymerase kappa isoform X2

      UniProtKB/TrEMBL
      A0A8C0PTJ1, A0A8I3NJG1, A0A8P0SUW1
      Related
      ENSCAFP00845015867.1, ENSCAFT00845020240.1
      Conserved Domains (3) summary
      smart00734
      Location:577 → 603
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 472
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:534 → 661
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    6. XM_038661022.1 → XP_038516950.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    7. XM_038661021.1 → XP_038516949.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    8. XM_038661024.1 → XP_038516952.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    9. XM_038661026.1 → XP_038516954.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049263.1 Alternate UMICH_Zoey_3.1

      Range
      30654748..30720406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038471598.1 → XP_038327526.1  DNA polymerase kappa isoform X1

    2. XM_038471599.1 → XP_038327527.1  DNA polymerase kappa isoform X1

    3. XM_038471603.1 → XP_038327531.1  DNA polymerase kappa isoform X3

      Conserved Domains (3) summary
      cd03586
      Location:104 → 436
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:498 → 625
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cl02765
      Location:687 → 713
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain

    4. XM_038471600.1 → XP_038327528.1  DNA polymerase kappa isoform X1

    5. XM_038471597.1 → XP_038327525.1  DNA polymerase kappa isoform X1

    6. XM_038471604.1 → XP_038327532.1  DNA polymerase kappa isoform X4

    7. XM_038471602.1 → XP_038327530.1  DNA polymerase kappa isoform X2

    8. XM_038471596.1 → XP_038327524.1  DNA polymerase kappa isoform X1

    9. XM_038471601.1 → XP_038327529.1  DNA polymerase kappa isoform X1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

      Range
      30624393..30691008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038596813.1 → XP_038452741.1  DNA polymerase kappa isoform X1

      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    2. XM_038596814.1 → XP_038452742.1  DNA polymerase kappa isoform X1

      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    3. XM_038596818.1 → XP_038452746.1  DNA polymerase kappa isoform X3

      Conserved Domains (3) summary
      cd03586
      Location:104 → 436
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:498 → 625
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cl02765
      Location:687 → 713
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain

    4. XM_038596815.1 → XP_038452743.1  DNA polymerase kappa isoform X1

      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    5. XM_038596812.1 → XP_038452740.1  DNA polymerase kappa isoform X1

      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    6. XM_038596819.1 → XP_038452747.1  DNA polymerase kappa isoform X4

      Conserved Domains (3) summary
      smart00734
      Location:526 → 552
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:80 → 421
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:483 → 610
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    7. XM_038596817.1 → XP_038452745.1  DNA polymerase kappa isoform X2

      Conserved Domains (3) summary
      smart00734
      Location:577 → 603
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 472
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:534 → 661
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    8. XM_038596811.1 → XP_038452739.1  DNA polymerase kappa isoform X1

      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    9. XM_038596816.1 → XP_038452744.1  DNA polymerase kappa isoform X1

      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

      Range
      31002435..31068944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038532530.1 → XP_038388458.1  DNA polymerase kappa isoform X3

      UniProtKB/TrEMBL
      A0A8C0PTJ1

    2. XM_038532531.1 → XP_038388459.1  DNA polymerase kappa isoform X3

      UniProtKB/TrEMBL
      A0A8C0PTJ1

    3. XM_038532535.1 → XP_038388463.1  DNA polymerase kappa isoform X6

    4. XM_038532534.1 → XP_038388462.1  DNA polymerase kappa isoform X5

      UniProtKB/TrEMBL
      A0A8C0PTJ1

    5. XM_038532532.1 → XP_038388460.1  DNA polymerase kappa isoform X3

      UniProtKB/TrEMBL
      A0A8C0PTJ1

    6. XM_038532529.1 → XP_038388457.1  DNA polymerase kappa isoform X3

      UniProtKB/TrEMBL
      A0A8C0PTJ1

    7. XM_038532528.1 → XP_038388456.1  DNA polymerase kappa isoform X3

      UniProtKB/TrEMBL
      A0A8C0PTJ1

    8. XM_038532533.1 → XP_038388461.1  DNA polymerase kappa isoform X3

      UniProtKB/TrEMBL
      A0A8C0PTJ1

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      32036886..32103334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014112271.3 → XP_013967746.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    2. XM_014112270.3 → XP_013967745.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    3. XM_038472405.1 → XP_038328333.1  DNA polymerase kappa isoform X3

      UniProtKB/TrEMBL
      A0A8C0PTJ1
      Conserved Domains (3) summary
      cd03586
      Location:104 → 436
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:498 → 625
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cl02765
      Location:687 → 713
      zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain

    4. XM_014112274.3 → XP_013967749.1  DNA polymerase kappa isoform X4

      UniProtKB/TrEMBL
      A0A8C0PTJ1
      Conserved Domains (3) summary
      smart00734
      Location:526 → 552
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:80 → 421
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:483 → 610
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    5. XM_014112272.3 → XP_013967747.1  DNA polymerase kappa isoform X2

      UniProtKB/TrEMBL
      A0A8C0PTJ1, A0A8I3NJG1, A0A8P0SUW1
      Conserved Domains (3) summary
      smart00734
      Location:577 → 603
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 472
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:534 → 661
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    6. XM_022416785.2 → XP_022272493.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    7. XM_014112269.3 → XP_013967744.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    8. XM_014112268.3 → XP_013967743.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    9. XM_022416786.2 → XP_022272494.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8C0LT88, A0A8C0N3I6, A0A8C0PTJ1, A0A8I3NI78
      Conserved Domains (3) summary
      smart00734
      Location:621 → 647
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:104 → 516
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      COG5432
      Location:578 → 705
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    Nucleotide Protein
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