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    HEMK1 HemK methyltransferase family member 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 476613, updated on 5-Mar-2024

    Summary

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    Official Symbol
    HEMK1provided by VGNC
    Official Full Name
    HemK methyltransferase family member 1provided by VGNC
    Primary source
    VGNC:VGNC:41655
    See related
    Ensembl:ENSCAFG00845020513
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 20
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (39143662..39154088, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (38708735..38719161, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (39195099..39205525, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (38511568..38521993, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (38915157..38925778, complement)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102152043 Neighboring gene cytokine inducible SH2 containing protein Neighboring gene chromosome 20 C3orf18 homolog Neighboring gene uncharacterized LOC102152848

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein methylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hemK methyltransferase family member 1; MTRF1L release factor glutamine methyltransferase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      39143662..39154088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038427662.1 → XP_038283590.1  MTRF1L release factor glutamine methyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8C0MXU7
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 287
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    2. XM_038427655.1 → XP_038283583.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    3. XM_038427661.1 → XP_038283589.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Related
      ENSCAFP00845028278.1, ENSCAFT00845036137.1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    4. XM_038427659.1 → XP_038283587.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    5. XM_038427656.1 → XP_038283584.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    6. XM_038427657.1 → XP_038283585.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    7. XM_038427660.1 → XP_038283588.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    8. XM_038427658.1 → XP_038283586.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    9. XM_038427663.1 → XP_038283591.1  MTRF1L release factor glutamine methyltransferase isoform X3

      UniProtKB/TrEMBL
      A0A8C0L931
      Conserved Domains (1) summary
      TIGR03534
      Location:28 → 280
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    10. XM_038427664.1 → XP_038283592.1  MTRF1L release factor glutamine methyltransferase isoform X4

      Conserved Domains (1) summary
      TIGR03534
      Location:1 → 225
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049280.1 Alternate UMICH_Zoey_3.1

      Range
      38511568..38521993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038503349.1 → XP_038359277.1  MTRF1L release factor glutamine methyltransferase isoform X2

      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 287
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    2. XM_038503342.1 → XP_038359270.1  MTRF1L release factor glutamine methyltransferase isoform X1

      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    3. XM_038503348.1 → XP_038359276.1  MTRF1L release factor glutamine methyltransferase isoform X1

      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    4. XM_038503346.1 → XP_038359274.1  MTRF1L release factor glutamine methyltransferase isoform X1

      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    5. XM_038503343.1 → XP_038359271.1  MTRF1L release factor glutamine methyltransferase isoform X1

      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    6. XM_038503344.1 → XP_038359272.1  MTRF1L release factor glutamine methyltransferase isoform X1

      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    7. XM_038503347.1 → XP_038359275.1  MTRF1L release factor glutamine methyltransferase isoform X1

      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    8. XM_038503345.1 → XP_038359273.1  MTRF1L release factor glutamine methyltransferase isoform X1

      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    9. XM_038503350.1 → XP_038359278.1  MTRF1L release factor glutamine methyltransferase isoform X3

      Conserved Domains (1) summary
      TIGR03534
      Location:28 → 280
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    10. XM_038503351.1 → XP_038359279.1  MTRF1L release factor glutamine methyltransferase isoform X4

      Conserved Domains (1) summary
      TIGR03534
      Location:1 → 225
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      38915157..38925778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038630500.1 → XP_038486428.1  MTRF1L release factor glutamine methyltransferase isoform X2

    2. XM_038630494.1 → XP_038486422.1  MTRF1L release factor glutamine methyltransferase isoform X1

    3. XM_038630498.1 → XP_038486426.1  MTRF1L release factor glutamine methyltransferase isoform X1

    4. XM_038630496.1 → XP_038486424.1  MTRF1L release factor glutamine methyltransferase isoform X1

    5. XM_038630495.1 → XP_038486423.1  MTRF1L release factor glutamine methyltransferase isoform X1

    6. XM_038630501.1 → XP_038486429.1  MTRF1L release factor glutamine methyltransferase isoform X3

    7. XM_038630497.1 → XP_038486425.1  MTRF1L release factor glutamine methyltransferase isoform X1

    8. XM_038630499.1 → XP_038486427.1  MTRF1L release factor glutamine methyltransferase isoform X1

    9. XM_038630502.1 → XP_038486430.1  MTRF1L release factor glutamine methyltransferase isoform X4

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      39195099..39205525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038566348.1 → XP_038422276.1  MTRF1L release factor glutamine methyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8C0MXU7
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 287
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    2. XM_038566341.1 → XP_038422269.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    3. XM_038566347.1 → XP_038422275.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    4. XM_038566345.1 → XP_038422273.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    5. XM_038566342.1 → XP_038422270.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    6. XM_038566343.1 → XP_038422271.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    7. XM_038566346.1 → XP_038422274.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    8. XM_038566344.1 → XP_038422272.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    9. XM_038566349.1 → XP_038422277.1  MTRF1L release factor glutamine methyltransferase isoform X3

      UniProtKB/TrEMBL
      A0A8C0L931
      Conserved Domains (1) summary
      TIGR03534
      Location:28 → 280
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    10. XM_038566350.1 → XP_038422278.1  MTRF1L release factor glutamine methyltransferase isoform X4

      Conserved Domains (1) summary
      TIGR03534
      Location:1 → 225
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      38708735..38719161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014122189.3 → XP_013977664.1  MTRF1L release factor glutamine methyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8C0MXU7
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 287
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    2. XM_005632495.4 → XP_005632552.1  MTRF1L release factor glutamine methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_005632552.1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    3. XM_533816.7 → XP_533816.2  MTRF1L release factor glutamine methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_533816.2

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    4. XM_038455306.1 → XP_038311234.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    5. XM_005632496.4 → XP_005632553.1  MTRF1L release factor glutamine methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_005632553.1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    6. XM_038455305.1 → XP_038311233.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    7. XM_014122188.3 → XP_013977663.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    8. XM_022406676.2 → XP_022262384.1  MTRF1L release factor glutamine methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0MXU7, A0A8C0SLZ4, A0A8I3S4G1
      Conserved Domains (1) summary
      TIGR03534
      Location:63 → 332
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    9. XM_005632499.4 → XP_005632556.1  MTRF1L release factor glutamine methyltransferase isoform X3

      UniProtKB/TrEMBL
      A0A8C0L931
      Conserved Domains (1) summary
      TIGR03534
      Location:28 → 280
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

    10. XM_038455307.1 → XP_038311235.1  MTRF1L release factor glutamine methyltransferase isoform X4

      Conserved Domains (1) summary
      TIGR03534
      Location:1 → 225
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
    Nucleotide Protein
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