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    PNPLA8 patatin like phospholipase domain containing 8 [ Canis lupus familiaris (dog) ]

    Gene ID: 475880, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PNPLA8provided by VGNC
    Official Full Name
    patatin like phospholipase domain containing 8provided by VGNC
    Primary source
    VGNC:VGNC:44758
    See related
    Ensembl:ENSCAFG00845022366
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PNPLA8 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (12406088..12453716)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (11779378..11825993)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (12371185..12418564)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (12223261..12270831)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (12143880..12191247)

    Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102152560 Neighboring gene NME/NM23 family member 8 Neighboring gene uncharacterized LOC119864172 Neighboring gene neuronal cell adhesion molecule Neighboring gene laminin subunit beta 4 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A PNPLA8 frameshift variant in Australian shepherd dogs with hereditary ataxia. Abitbol M, et al. Anim Genet, 2022 Oct. PMID 35864734, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A PNPLA8 frameshift variant in Australian shepherd dogs with hereditary ataxia.
      Title: A PNPLA8 frameshift variant in Australian shepherd dogs with hereditary ataxia.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arachidonic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium-independent phospholipase A2-gamma
    XP_005630992.1
    XP_022260900.1
    XP_038279664.1
    XP_038279665.1
    XP_038279666.1
    XP_038356021.1
    XP_038356022.1
    XP_038356023.1
    XP_038418611.1
    XP_038418612.1
    XP_038418613.1
    XP_038482694.1
    XP_038482695.1
    XP_038482696.1
    XP_533087.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051822.1 Reference ROS_Cfam_1.0

      Range
      12406088..12453716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038423736.1 → XP_038279664.1  calcium-independent phospholipase A2-gamma isoform X1

      UniProtKB/TrEMBL
      A0A8C0PBD4, A0A8C0S9W8, A0A8I3PEV9
      Related
      ENSCAFP00845031023.1, ENSCAFT00845039600.1
      Conserved Domains (1) summary
      cd07211
      Location:437 → 743
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

    2. XM_038423737.1 → XP_038279665.1  calcium-independent phospholipase A2-gamma isoform X2

      UniProtKB/TrEMBL
      A0A8C0PBD4
      Conserved Domains (1) summary
      cd07211
      Location:336 → 642
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

    3. XM_038423738.1 → XP_038279666.1  calcium-independent phospholipase A2-gamma isoform X3

      UniProtKB/TrEMBL
      A0A8I3PEJ7, A0A8P0S9B0
      Conserved Domains (1) summary
      cl11396
      Location:437 → 628
      Patatin_and_cPLA2; Patatins and Phospholipases

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049278.1 Alternate UMICH_Zoey_3.1

      Range
      12223261..12270831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038500093.1 → XP_038356021.1  calcium-independent phospholipase A2-gamma isoform X1

      Conserved Domains (1) summary
      cd07211
      Location:437 → 743
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

    2. XM_038500094.1 → XP_038356022.1  calcium-independent phospholipase A2-gamma isoform X2

      Conserved Domains (1) summary
      cd07211
      Location:336 → 642
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

    3. XM_038500095.1 → XP_038356023.1  calcium-independent phospholipase A2-gamma isoform X3

      Conserved Domains (1) summary
      cl11396
      Location:437 → 628
      Patatin_and_cPLA2; Patatins and Phospholipases

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

      Range
      12143880..12191247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038626766.1 → XP_038482694.1  calcium-independent phospholipase A2-gamma isoform X1

      Conserved Domains (1) summary
      cd07211
      Location:437 → 743
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

    2. XM_038626767.1 → XP_038482695.1  calcium-independent phospholipase A2-gamma isoform X2

      Conserved Domains (1) summary
      cd07211
      Location:336 → 642
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

    3. XM_038626768.1 → XP_038482696.1  calcium-independent phospholipase A2-gamma isoform X3

      Conserved Domains (1) summary
      cl11396
      Location:437 → 628
      Patatin_and_cPLA2; Patatins and Phospholipases

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

      Range
      12371185..12418564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038562683.1 → XP_038418611.1  calcium-independent phospholipase A2-gamma isoform X1

      UniProtKB/TrEMBL
      A0A8C0LK45, A0A8C0PBD4

    2. XM_038562684.1 → XP_038418612.1  calcium-independent phospholipase A2-gamma isoform X2

      UniProtKB/TrEMBL
      A0A8C0PBD4

    3. XM_038562685.1 → XP_038418613.1  calcium-independent phospholipase A2-gamma isoform X3

      UniProtKB/TrEMBL
      A0A8I3PEJ7, A0A8P0S9B0

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      11779378..11825993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005630935.3 → XP_005630992.1  calcium-independent phospholipase A2-gamma isoform X1

      See identical proteins and their annotated locations for XP_005630992.1

      UniProtKB/TrEMBL
      A0A8C0PBD4, A0A8C0S9W8, A0A8I3PEV9
      Conserved Domains (1) summary
      cd07211
      Location:437 → 743
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

    2. XM_533087.6 → XP_533087.4  calcium-independent phospholipase A2-gamma isoform X2

      See identical proteins and their annotated locations for XP_533087.4

      UniProtKB/TrEMBL
      A0A8C0PBD4
      Conserved Domains (1) summary
      cd07211
      Location:336 → 642
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

    3. XM_022405192.2 → XP_022260900.1  calcium-independent phospholipase A2-gamma isoform X4

      UniProtKB/TrEMBL
      A0A8I3PEJ7, A0A8P0S9B0
      Conserved Domains (1) summary
      cl11396
      Location:437 → 628
      Patatin_and_cPLA2; Patatins and Phospholipases
    Nucleotide Protein
    Heading Accession and Version

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