agbl5 AGBL carboxypeptidase 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: agbl5provided by ZNC
Official Full Name: AGBL carboxypeptidase 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-040822-29
See related: Ensembl:ENSDARG00000045900 AllianceGenome:ZFIN:ZDB-GENE-040822-29
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:91997
Summary: Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Acts upstream of or within chordate embryonic development and cilium assembly. Predicted to be located in several cellular components, including cytosol; midbody; and mitotic spindle. Is expressed in several structures, including Kupffer's vesicle; axis; forerunner cell group; nervous system; and pronephros. Human ortholog(s) of this gene implicated in retinitis pigmentosa 75. Orthologous to human AGBL5 (AGBL carboxypeptidase 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (737539..760615, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (724091..747149, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ccp5 is the principal tubulin deglutamylase that maintains functional levels of cilia tubulin glutamylation.
Title: Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
These data suggest that CCP1 and CCP5 play important roles in developmental processes, particularly the development and functioning of cilia.
Title: Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development.

Submit: New GeneRIF Correction

General gene information

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Markers

fc15f09.x1 (e-PCR)
- UniSTS:203823

G47470 (e-PCR)
- UniSTS:108246

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytosolic carboxypeptidase-like protein 5

Names: ATP/GTP binding protein-like 5; CCP5; protein deglutamylase CCP5

NP_001004113.1

EC 3.4.17.24

XP_017210489.1

EC 3.4.17.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004113.1 → NP_001004113.1 cytosolic carboxypeptidase-like protein 5

See identical proteins and their annotated locations for NP_001004113.1

Status: PROVISIONAL

Source sequence(s)

BC080248

UniProtKB/Swiss-Prot

Q68EI3

Related

ENSDARP00000094377.3, ENSDART00000103601.4

Conserved Domains (1) summary

cd06236
Location:171 → 574

M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins