U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PEG3 paternally expressed 3 [ Bos taurus (cattle) ]

    Gene ID: 444864, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PEG3provided by VGNC
    Official Full Name
    paternally expressed 3provided by VGNC
    Primary source
    VGNC:VGNC:109388
    See related
    Ensembl:ENSBTAG00000054572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 18
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (64099192..64122748, complement)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC508098 Neighboring gene uncharacterized LOC789809 Neighboring gene microRNA mir-2900 Neighboring gene antisense transcript gene of PEG3 Neighboring gene uncharacterized LOC789803 Neighboring gene transfer RNA glutamic acid (anticodon UUC)

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. PEG3 domain gene expression in maternal and foetal placenta in intrauterine growth restricted bovine foetuses. Li S, et al. Anim Genet, 2016 Feb. PMID 26537866
    2. A novel mutation in the maternally imprinted PEG3 domain results in a loss of MIMT1 expression and causes abortions and stillbirths in cattle (Bos taurus). Flisikowski K, et al. PLoS One, 2010 Nov 30. PMID 21152099, Free PMC Article
    3. Aberrant DNA methylation imprints in aborted bovine clones. Liu JH, et al. Mol Reprod Dev, 2008 Apr. PMID 17886268
    4. Lineage-specific imprinting and evolution of the zinc-finger gene ZIM2. Kim J, et al. Genomics, 2004 Jul. PMID 15203203
    5. DNA methylation analysis of the mammalian PEG3 imprinted domain. Huang JM, et al. Gene, 2009 Aug 1. PMID 19397955, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the expression of PEG3 domain genes within the maternal placenta is not significantly affected by the MIMT1Del mutation and alterations in PEG3 domain gene expression on the fetal side
      Title: PEG3 domain gene expression in maternal and foetal placenta in intrauterine growth restricted bovine foetuses.
    2. Data show that a 110 kb microdeletion in the maternally imprinted PEG3 domain that results in a loss of paternal MIMT1 expression and causes late term abortion and stillbirth.
      Title: A novel mutation in the maternally imprinted PEG3 domain results in a loss of MIMT1 expression and causes abortions and stillbirths in cattle (Bos taurus).
    3. PEG3 imprinted domain of humans, cows, and mice contains differing numbers of differentially methylated regions (DMR), but the PEG3-CpG island is the only DMR that is conserved among these three species.
      Title: DNA methylation analysis of the mammalian PEG3 imprinted domain.
    4. Peg3 was seriously demethylated or showed aberrant methylation patterns in four aborted clones.
      Title: Aberrant DNA methylation imprints in aborted bovine clones.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    paternally-expressed gene 3 protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002887.3 → NP_001002887.3  paternally-expressed gene 3 protein

      Status: VALIDATED

      Source sequence(s)
      NKLS02000018
      UniProtKB/TrEMBL
      A0A3Q1LMU6
      Related
      ENSBTAP00000058056.2, ENSBTAT00000073956.2
      Conserved Domains (5) summary
      PRK10263
      Location:1485 → 1792
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:2037 → 2057
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:2092 → 2114
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:40 → 127
      SCAN; SCAN domain
      pfam03157
      Location:935 → 1636
      Glutenin_hmw; High molecular weight glutenin subunit

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      64099192..64122748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6H236.1 GenPept UniProtKB/Swiss-Prot:Q6H236

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.