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    TCF21 transcription factor 21 [ Gallus gallus (chicken) ]

    Gene ID: 421697, updated on 5-Mar-2024

    Summary

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    Symbol
    TCF21provided by CGNC
    Full Name
    transcription factor 21provided by CGNC
    Primary source
    CGNC:66408
    See related
    Ensembl:ENSGALG00010006187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (55955807..55958287, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (55864085..55866564, complement)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 12 Neighboring gene TATA-box binding protein like 1 Neighboring gene uncharacterized LOC121110364 Neighboring gene uncharacterized LOC112532169

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide survey and functional analysis reveal TCF21 promotes chicken preadipocyte differentiation by directly upregulating HTR2A. Zhang X, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34872001
    2. Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart. Braitsch CM, et al. Dev Biol, 2012 Aug 15. PMID 22687751, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide survey and functional analysis reveal TCF21 promotes chicken preadipocyte differentiation by directly upregulating HTR2A.
      Title: Genome-wide survey and functional analysis reveal TCF21 promotes chicken preadipocyte differentiation by directly upregulating HTR2A.
    2. Data show that all-trans-retinoic acid (RA) inhibition leads to decreased Pod1/Tcf21 expression in intact heart.
      Title: Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277711.2 → NP_001264640.1  transcription factor 21

      See identical proteins and their annotated locations for NP_001264640.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000063
      UniProtKB/TrEMBL
      R4GLC9
      Conserved Domains (1) summary
      cd19704
      Location:77 → 140
      bHLH_TS_TCF21_capsulin; basic helix-loop-helix (bHLH) domain found in transcription factor 21 (TCF-21) and similar proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      55955807..55958287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046938859.1 → XP_046794815.1  transcription factor 21 isoform X2

    2. XM_046938857.1 → XP_046794813.1  transcription factor 21 isoform X1

      UniProtKB/TrEMBL
      R4GLC9
      Related
      ENSGALP00010008680.1, ENSGALT00010014730.1

    3. XM_046938858.1 → XP_046794814.1  transcription factor 21 isoform X1

      UniProtKB/TrEMBL
      R4GLC9

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      55864085..55866564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046913991.1 → XP_046769947.1  transcription factor 21 isoform X2

    2. XM_046913989.1 → XP_046769945.1  transcription factor 21 isoform X1

      UniProtKB/TrEMBL
      R4GLC9

    3. XM_046913990.1 → XP_046769946.1  transcription factor 21 isoform X1

      UniProtKB/TrEMBL
      R4GLC9
    Nucleotide Protein
    Heading Accession and Version

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