LY86 lymphocyte antigen 86 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: LY86provided by CGNC
Official Full Name: lymphocyte antigen 86provided by CGNC
Primary source: CGNC:9703
See related: Ensembl:ENSGALG00010010896
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: MD1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (64625932..64649625, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (64574845..64598537, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structure of MD-1 at 2.0 A resolution exhibits a beta-cup-like fold, similar to MD-2, that encloses a hydrophobic cavity between the two beta-sheets.
Title: Crystal structure of soluble MD-1 and its interaction with lipid IVa.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: lymphocyte antigen 86

Names: MD-1 protein; ly-86; protein MD-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004399.2 → NP_001004399.2 lymphocyte antigen 86 precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000040

UniProtKB/Swiss-Prot

Q90890

Related

ENSGALP00010014708.1, ENSGALT00010026068.1

Conserved Domains (1) summary

cd00915
Location:25 → 154

MD-1_MD-2; MD-1 and MD-2 are cofactors required for LPS signaling through cell surface receptors. MD-2 and its binding partner, Toll-like receptor 4 (TLR4), are essential for the innate immune responses of mammalian cells to bacterial lipopolysaccharide (LPS); MD-2 ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

64625932..64649625 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

64574845..64598537 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)