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    TWF1 twinfilin actin binding protein 1 [ Gallus gallus (chicken) ]

    Gene ID: 417797, updated on 5-Mar-2024

    Summary

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    Symbol
    TWF1provided by CGNC
    Full Name
    twinfilin actin binding protein 1provided by CGNC
    Primary source
    CGNC:7305
    See related
    Ensembl:ENSGALG00010001899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PTK9
    Orthologs
    human mouse all
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    Genomic context

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    See TWF1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (30222781..30241225, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (30560761..30579215, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene pseudouridylate synthase 7 like Neighboring gene interleukin 1 receptor associated kinase 4 Neighboring gene uncharacterized LOC121106856 Neighboring gene transmembrane protein 117 Neighboring gene P2Y purinoceptor 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
    2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sequestering of actin monomers IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    twinfilin-1
    Names
    PTK9 protein tyrosine kinase 9
    twinfilin 1
    twinfilin, actin-binding protein, homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030739.2 → NP_001025910.1  twinfilin-1 isoform 2

      See identical proteins and their annotated locations for NP_001025910.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons and its transcription extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAENSK010000012
      UniProtKB/TrEMBL
      A0A8V0X7K4, E1C198, Q5ZLN3
      Related
      ENSGALP00010002616.1, ENSGALT00010004338.1
      Conserved Domains (1) summary
      cd11285
      Location:4 → 142
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    2. NM_001278095.2 → NP_001265024.1  twinfilin-1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAENSK010000012
      UniProtKB/TrEMBL
      A0A8V0X7L4, A0A8V0XDW8
      Related
      ENSGALP00010002629.1, ENSGALT00010004351.1
      Conserved Domains (2) summary
      cd11284
      Location:176 → 311
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:4 → 142
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    3. NM_001397033.1 → NP_001383962.1  twinfilin-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000012
      Conserved Domains (2) summary
      cd11284
      Location:78 → 213
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cl15697
      Location:1 → 44
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      30222781..30241225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      30560761..30579215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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